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Vol. 38 No. 6 (2026): Vol. 38 Issue No 6, 2026

Copyright (c) 2026 Truong Nhan Ngu, Thi Bich Hanh Dam, Phuong Dai Nguyen Nguyen, Thi Thuy Loan Le, Dao Cuong To, Tien Lam Do

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Microwave-Assisted Extraction of Ludwigia adscendens Volatile Compounds and their Antioxidant, Antibacterial and Anti-α-glucosidase Activities

https://doi.org/10.14233/ajchem.2026.35837
Truong Nhan Ngu
Faculty of Natural Sciences and Technology, Tay Nguyen University, 567 Le Duan, Ea Kao, Daklak 630000, Vietnam
https://orcid.org/0000-0002-4387-685X
Thi Bich Hanh Dam
Faculty of Natural Sciences and Technology, Tay Nguyen University, 567 Le Duan, Ea Kao, Daklak 630000, Vietnam
https://orcid.org/0000-0003-3536-4800
Phuong Dai Nguyen Nguyen
Faculty of Natural Sciences and Technology, Tay Nguyen University, 567 Le Duan, Ea Kao, Daklak 630000, Vietnam
https://orcid.org/0009-0006-1967-7996
Thi Thuy Loan Le
Faculty of Natural Sciences and Technology, Tay Nguyen University, 567 Le Duan, Ea Kao, Daklak 630000, Vietnam
https://orcid.org/0000-0003-2927-6695
Dao Cuong To
Phenikaa University Nano Institute (PHENA), Phenikaa School of Engineering (PSE), Phenikaa University, Nguyen Trac, Duong Noi, Hanoi 12116, Vietnam
https://orcid.org/0009-0001-2954-8702
Tien Lam Do
Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghia Do, Hanoi 122100, Vietnam
https://orcid.org/0000-0002-6573-6428

Corresponding Author(s) : Tien Lam Do

dotienlam198@gmail.com

Asian Journal of Chemistry, Vol. 38 No. 6 (2026): Vol. 38 Issue No 6, 2026

Abstract

Ludwigia adscendens is widely used in traditional medicine to treat various inflammatory and intestinal diseases. However, its volatile chemical profile and associated biological properties remain rarely investigated. In this study, microwave-assisted extraction (MAE) was employed to efficiently isolate the volatile compounds from L. adscendens collected in Dak Lak, Vietnam. The chemical composition of the extract was comprehensively analysed using gas chromatography-mass spectrometry (GC-MS). Biological potentials were evaluated through DPPH free radical scavenging assay, agar disc diffusion and spectrophotometric methods. GC-MS analysis identified 54 compounds, accounting for 95.68% of the total volatile extract. The major constituents were β-caryophyllene (23.52%), methyleugenol (16.54%), α-terpinene (11.20%), (-)-α-thujene (9.49%), D-limonene (8.04%) and β-myrcene (5.97%). The volatile extract exhibited moderate antioxidant and antibacterial activities, with an IC50 value of 2.46 mg/mL and an Escherichia coli inhibition rate of 86.94% (at 2.00 mg/mL), respectively. Moreover, the extract showed weak anti-α-glucosidase activity with an IC50 value of 4.81 mg/mL. These findings demonstrate the application of MAE in recovering bioactive molecules and underscore the potential of L. adscendens volatile compounds as a natural source for pharmaceutical and therapeutic applications.

Keywords

Ludwigia adscendens Volatile compounds Microwave-assisted extraction Antioxidant Antibacterial α-Glucosidase
(1)
Ngu, T. N.; Dam, T. B. H.; Nguyen, P. D. N.; Le, T. T. L.; To, D. C.; Do, T. L. Microwave-Assisted Extraction of Ludwigia Adscendens Volatile Compounds and Their Antioxidant, Antibacterial and Anti-α-Glucosidase Activities. ajc 2026, 38, 1505-1514.
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