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Vol. 38 No. 5 (2026): Vol 38, Issue 5, 2026

Copyright (c) 2026 Sneha Panneerselvam, Safiq Hussain Jahir, Lisha Kumar, Kiruthika Ganesan, Renukadevi Jeyavelkumaran

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Molecular Design and Characterisation of Hyaluronic Acid-Based Nanogel Sponges for Controlled Glutathione Release and Wound Healing

https://doi.org/10.14233/ajchem.2026.35079
Sneha Panneerselvam
Department of Pharmaceutics, Saveetha College of Pharmacy, Saveetha Institute of Medical and Technical Sciences, Chennai-602105, India
https://orcid.org/0009-0001-1334-0771
Safiq Hussain Jahir
Department of Pharmaceutics, Saveetha College of Pharmacy, Saveetha Institute of Medical and Technical Sciences, Chennai-602105, India
https://orcid.org/0009-0000-4513-1424
Lisha Kumar
Department of Pharmaceutics, Saveetha College of Pharmacy, Saveetha Institute of Medical and Technical Sciences, Chennai-602105, India
https://orcid.org/0009-0006-0329-3824
Kiruthika Ganesan
Department of Pharmaceutics, Saveetha College of Pharmacy, Saveetha Institute of Medical and Technical Sciences, Chennai-602105, India
https://orcid.org/0009-0002-5284-3379
Renukadevi Jeyavelkumaran
Department of Pharmaceutics, Saveetha College of Pharmacy, Saveetha Institute of Medical and Technical Sciences, Chennai-602105, India
https://orcid.org/0000-0002-4327-3661

Corresponding Author(s) : Renukadevi Jeyavelkumaran

neelarenu@gmail.com

Asian Journal of Chemistry, Vol. 38 No. 5 (2026): Vol 38, Issue 5, 2026

Abstract

The development of sustainable, bio-based polymeric materials with controlled release functionality is of growing interest for advanced wound-healing applications. In this study, a hyaluronic acid (HA) based nanogel sponge scaffold incorporating glutathione (GSH) loaded chitosan nanogels was rationally designed using ionic gelation followed by freeze-drying. This green and mild fabrication strategy enabled the stabilisation of the redox-active thiol functionality of GSH while generating a hierarchically porous HA sponge architecture. Comprehensive physico-chemical characterisation using UV-diffuse reflectance spectroscopy, FTIR, differential scanning calorimetry, zeta potential analysis, dynamic light scattering, scanning electron microscopy and transmission electron microscopy confirmed successful molecular integration, preservation of functional groups, nanoscale uniformity, interconnected porosity and satisfactory thermal and colloidal stability. The scaffold exhibited a controlled, diffusion-driven swelling profile, supporting sustained moisture retention under simulated wound conditions. In vitro anti-inflammatory evaluation demonstrated concentration-dependent inhibition of bovine serum albumin and egg albumin denaturation, along with significant red blood cell membrane stabilisation, with higher concentrations approaching the activity of the reference drug. These findings demonstrate that HA-GSH nanogel sponges represent a sustainably engineered, redox-responsive polymer system capable of providing structural support, controlled molecular release and anti-inflammatory functionality. This study contributes to the advancement of bio-based polysaccharide materials and green nanogel synthesis related to health, responsible production and materials innovation.

Keywords

Biopolysaccharides Green nanogel Redox-responsive polymers Hierarchical materials Controlled molecular release
(1)
Panneerselvam, S.; Jahir, S. H.; Kumar, L.; Ganesan, K.; Jeyavelkumaran, R. Molecular Design and Characterisation of Hyaluronic Acid-Based Nanogel Sponges for Controlled Glutathione Release and Wound Healing. ajc 2026, 38, 1212-1220.
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