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Vol. 38 No. 4 (2026): Vol 38 Issue 4, 2026

Copyright (c) 2026 V Jaisankar V, Renukadevi S, Deepan Kumar B, Hari Hara Priya G, Tamizharuvi T

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis and Characterisation of β-Cyclodextrin-Conjugated Carboxymethyl Chitosan Derivative for Antimicrobial and Wound Healing Applications

https://doi.org/10.14233/ajchem.2026.34988
S. Renukadevi
PG and Research Department of Chemistry, Presidency College (Autonomous), Chennai-600005, India
https://orcid.org/0009-0005-6513-7491
B. Deepan Kumar
Department of Chemistry, Institute of Chemical Technology, Tharamani, Chennai-600113, India
https://orcid.org/0009-0003-0546-8198
G. Hari Hara Priya
PG Department of Chemistry, Shrimathi Devkunvar Nanalal Bhatt Vaishnav College for Women, Chennai-600044, India
https://orcid.org/0000-0003-0229-8827
T. Tamizharuvi
PG and Research Department of Chemistry, Presidency College (Autonomous), Chennai-600005, India
https://orcid.org/0009-0005-2519-5419
V. Jaisankar
PG and Research Department of Chemistry, Presidency College (Autonomous), Chennai-600005, India
https://orcid.org/0000-0003-0894-4703

Corresponding Author(s) : V. Jaisankar

vjaisankar@gmail.com

Asian Journal of Chemistry, Vol. 38 No. 4 (2026): Vol 38 Issue 4, 2026

Abstract

Chitosan can be chemically modified to form a range of derivatives to perform enhanced biological activities with enhanced solubility in water and functional properties. These alterations have tunned their applications towards biomedical fields. This work aims to synthesize the carboxymethyl derivative of chitosan selectively functionalised at the C6 carbon atom through careful masking of the C2 location. In this regard, the C2-amino group was shielded to avoid interfering with the carboxymethylation process at the C6 hydroxyl group. The functional characteristics of the chitosan derivative were further improved by conjugating it with β-cyclodextrin to form a β-cyclodextrin-carboxymethyl chitosan (CD-CMCh) derivative. Further biological potential was tested on the derivative emphasizing its significant activity against the bacteria S. aureus (13 ± 2 mm), E. coli (9 ± 1 mm) and K. pnemoniae (11 ± 2 mm) at the concentration of 1000 µg/mL, along with the potent activity against fungal A. niger (19 ± 5.7 mm, 16.37 ± 7.6 mm) and T. viride (13.3 ± 3.5 mm, 12.7 ± 5 mm) at the concentration 1000 and 500 µg/mL, respectively than C. albicans. Furthermore, the in vitro wound healing assay revealed a 65% wound closure, indicating substantial cell migration and regenerative potential. Results revealed that this selectively modified derivative is a flexible molecule in the production of biomedical materials and thus holds great promise for application in antimicrobial treatments and wound healing therapy.

Keywords

Biopolymer Carboxymethyl chitosan β-Cyclodextrin Antimicrobial activity Wound healing applications
(1)
Renukadevi, S.; Kumar, B. D.; Priya, G. H. H.; Tamizharuvi, T.; Jaisankar, V. Synthesis and Characterisation of β-Cyclodextrin-Conjugated Carboxymethyl Chitosan Derivative for Antimicrobial and Wound Healing Applications. ajc 2026, 38, 971-978.
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Author Biographies

B. Deepan Kumar, Department of Chemistry, Institute of Chemical Technology, Tharamani, Chennai-600113, India

Department of Chemistry, Institute of Chemical Technology, Tharamani, Chennai, INDIA-600 113

G. Hari Hara Priya, PG Department of Chemistry, Shrimathi Devkunvar Nanalal Bhatt Vaishnav College for Women, Chennai-600044, India

PG Department of Chemistry, Shrimathi Devkunvar Nanalal Bhatt Vaishnav College for Women, Chennai, Tamil Nadu, India

T. Tamizharuvi, PG and Research Department of Chemistry, Presidency College (Autonomous), Chennai-600005, India

Department of Chemistry, School of Sciences, Tamil Nadu Open University, Chennai – 600 015, Tamilnadu, India

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