Copyright (c) 2026 Ram Pal Chaudhary, Swati Goswami
This work is licensed under a Creative Commons Attribution 4.0 International License.
Ultrasound Assisted Synthesis, X-Ray Diffraction, DFT and Antibacterial Studies of Naphthalenyl-hydrazinyl- and Quinazolinyl-thiazole Derivatives
Corresponding Author(s) : R.P. Chaudhary
Asian Journal of Chemistry,
Vol. 38 No. 3 (2026): Vol 38 Issue 3, 2026
Abstract
Naphthalenyl-hydrazinecarbothioamides 2, obtained from reaction of 1-tetralones (1) and thiosemicarbazide, on condensation with ethyl bromopyruvate under ultrasonic conditions furnished thiazole-4-carboxylates (3). Ultrasound assisted synthesis of quinazoline-thiazole hybrids 5 was achieved from reaction of quinazolinyl-thiones (4) with 3-chloropentane-2,4-dione. The structural elucidation of novel compounds was determined with the help of spectral techniques. X-ray crystallographic studies (SCXRD) of single crystal of thiazole-4-carboxtylate 3a along with supramolecular interactions in crystal packing were also reported. In silico studies of regioisomers 5 and 6 were computed to correlate the experimental and theoretical spectral data. Compound 5a has shown good activity against S. aureus (MIC 25 µg/mL) and E. coli (50 µg/mL) bacterial strains.
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