Synthesis and Antifungal Activity of Aspirin Derivatives

Sumei Gao; Zhihong Xu; Xuesong Wang; Hui Feng; Ling Wang; Yuanjiang Zhao; Yue Wang; Xiaorong Tang

doi:10.14233/ajchem.2014.16535

Issue

Vol. 26 No. 21 (2014): Vol 26 Issue 21

Issue Published : September 30, 2014

This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis and Antifungal Activity of Aspirin Derivatives

https://doi.org/10.14233/ajchem.2014.16535

Sumei Gao

School of Physics and Chemistry, Xihua University, Chengdu 610039, P.R. China

Zhihong Xu

School of Physics and Chemistry, Xihua University, Chengdu 610039, P.R. China

Xuesong Wang

School of Physics and Chemistry, Xihua University, Chengdu 610039, P.R. China

Hui Feng

School of Bioengineering, Xihua University, Chengdu 610039, P.R. China

Ling Wang

School of Physics and Chemistry, Xihua University, Chengdu 610039, P.R. China

Yuanjiang Zhao

School of Physics and Chemistry, Xihua University, Chengdu 610039, P.R. China

Yue Wang

School of Physics and Chemistry, Xihua University, Chengdu 610039, P.R. China

Xiaorong Tang

School of Physics and Chemistry, Xihua University, Chengdu 610039, P.R. China

Corresponding Author(s) : Xiaorong Tang

tangxiaorong0901@163.com

Asian Journal of Chemistry, Vol. 26 No. 21 (2014): Vol 26 Issue 21
Article Published : September 30, 2014

Abstract

Using aspirin as a lead compound, a series of its derivatives (compounds 1-7) were designed and synthesized. Their activity of anti-pathogenic fungi of plants has been evaluated in the laboratory. The results showed that these compounds had good antifungal activity against Sclerotinia sclerotiorum, Helminthosprium maydis, Botrytis cinerea and Rhizoctonia solani. Among them, the inhibition of growth for compounds 1 and 2 against Helminthosprium maydis reached 92.5 and 91.6 % at a concentration of 100 mg L^-1, respectively, which was superior to carbendazim.

Keywords

N-amination reaction N-amino compounds Synthesis Characterization Crystal structure

Gao, S., Xu, Z., Wang, X., Feng, H., Wang, L., Zhao, Y., … Tang, X. (2014). Synthesis and Antifungal Activity of Aspirin Derivatives. Asian Journal of Chemistry, 26(21), 7157–7159. https://doi.org/10.14233/ajchem.2014.16535

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References

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References

X.J. Chen, M.J. Cao, Y. Wang, Y.H. Tong and J.Y. Xu, Chin. J. Oil Crop Sci., 31, 503 (2009).

Z.Q. Shi, M.G. Zhou and Z.Y. Ye, J. Jiangsu Agric., 16, 212 (2000).

W. Li, Y.J. Zhou and H.G. Chen, Chin. J. Oil Crop Sci., 29, 63 (2007).

K.Y. Liu and F.X. Chen, Anhui Agric. Sci., 35, 756 (2007).

Y.X. Qi, F.X. Chen and K.J. Ding, Pesticides, 8, 567 (2006).

A. Have, R. Berloo, P. Lindhout and J.A.L. Kan, Eur. J. Plant Pathol., 117, 153 (2007); doi:10.1007/s10658-006-9081-9.

S.I. Ignatova, N.S. Gorshkova and T.A. Tereshonkova, Acta Physiol. Plant., 22, 326 (2000); doi:10.1007/s11738-000-0047-9.

H. Egashira, A. Kuwashima, H. Ishiguro, K. Fukushima, T. Kaya and S. Imanishi, Acta Physiol. Plant., 22, 324 (2000); doi:10.1007/s11738-000-0046-x.

R.L. Guimaraes, R.T. Chetelat and H.U. Stotz, Eur. J. Plant Pathol., 110, 13 (2004); doi:10.1023/B:EJPP.0000010133.62052.e4.

R. Finkers, P. Berg, R. Berloo, A. Have, A.W. Heusden, J.A.L. Kan and P. Lindhout, Theor. Appl. Genet., 114, 585 (2007); doi:10.1007/s00122-006-0458-0.

R. Finkers, A.W. Heusden, F. Meijer-Dekens, J.A.L. Kan, P. Maris and P. Lindhout, Theor. Appl. Genet., 114, 1071 (2007); doi:10.1007/s00122-006-0500-2.

R. Finkers, Y. Bai, P. Berg, R. Berloo, F. Meijer-Dekens, A. Have, J. Kan, P. Lindhout and A.W. Heusden, Euphytica, 159, 83 (2007); doi:10.1007/s10681-007-9460-0.

D.W. Gilroy, Prostag. Leukotr. Ess., 73, 203 (2005); doi:10.1016/j.plefa.2005.05.007.

D.M. McCarthy, Best Pract. Res. Clin. Gastroenterol., 26, 101 (2012); doi:10.1016/j.bpg.2012.01.008.

R. Eccles, Int. Pharm. J., 6, 7 (1995).

C. Lampl, M. Voelker and H.C. Diener, J. Neurol., 254, 705 (2007); doi:10.1007/s00415-007-0547-2.

W. Huang and G.F. Yang, Bioorg. Med. Chem., 14, 8280 (2006); doi:10.1016/j.bmc.2006.09.016.

Issue

Vol. 26 No. 21 (2014): Vol 26 Issue 21

Synthesis and Antifungal Activity of Aspirin Derivatives

Corresponding Author(s) : Xiaorong Tang

Abstract

Keywords

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