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Vol. 31 No. 8 (2019): Vol 31 Issue 8

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Antifungal Activity of Synthesized Benzothiazole Derivatives using Structure Activity Relationship

https://doi.org/10.14233/ajchem.2019.21858
Madhu Toshniwal
Department of Chemistry, Government Women Engineering College, Ajmer-305002, India
Mahendra Bundel
Analytical & Pharmaceutical Research Laboratory, Department of Chemistry, S.P.R. Chauhan Government College, Ajmer-305001, India
Ravikant
Helix Bio Genesis Lab, Noida-226002, India
Arun Pareek
Analytical & Pharmaceutical Research Laboratory, Department of Chemistry, S.P.R. Chauhan Government College, Ajmer-305001, India

Corresponding Author(s) : Madhu Toshniwal

madhutoshniwal@gweca.ac.in

Asian Journal of Chemistry, Vol. 31 No. 8 (2019): Vol 31 Issue 8

Abstract

In the field of drug discovery the benzothiazole is found to be a magical compound. Computational tools were used to predict their molecular property, drug likeness, overall drug score and toxicity risks which are essential parameter for a chemical to be qualified as a drug. As good results were observed by computational tools then novel series of 2-amino-6-substituted benzothiazoles with halo ketone have been synthesized by conventional method. All the synthesized compounds have been characterized by elemental analysis and IR, 1H NMR data in full accordance with their expected (depicted) structures. The synthesized compounds were screened for their antifungal activity using standard drug ampicillin.

Keywords

Benzothiazole Halo-ketone Computational tool Antifungal activity
Toshniwal, M., Bundel, M., Ravikant, ., & Pareek, A. (2019). Antifungal Activity of Synthesized Benzothiazole Derivatives using Structure Activity Relationship. Asian Journal of Chemistry, 31(8), 1885–1888. https://doi.org/10.14233/ajchem.2019.21858
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