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Vol. 26 No. 21 (2014): Vol 26 Issue 21

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A New Cytotoxic Prenylated Chalcone from Desmodium renifolium

https://doi.org/10.14233/ajchem.2014.16538
Jie Lou
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan University of Nationalities, Kunming 650031, P.R. China*Corresponding author: E-mail: gao_xuemei@hotmail.com
Gui-You Liu
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan University of Nationalities, Kunming 650031, P.R. China
Huan Wang
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan University of Nationalities, Kunming 650031, P.R. China
Juan-Xia Yang
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan University of Nationalities, Kunming 650031, P.R. China
Limei Li
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan University of Nationalities, Kunming 650031, P.R. China
Qiu-Fen Hu
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan University of Nationalities, Kunming 650031, P.R. China; Collge of Resource and Environment, Yuxi Normal University, Yuxi 653100, P.R. China
Yan-Qing Ye
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan University of Nationalities, Kunming 650031, P.R. China
Xue-Mei Gao
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan University of Nationalities, Kunming 650031, P.R. China

Asian Journal of Chemistry, Vol. 26 No. 21 (2014): Vol 26 Issue 21

Abstract

A new prenylated chalcone, renifchalcone A (1) was isolated from the whole plants of Desmodium renifolium. Its structure was determined by spectroscopic methods, including 1D and 2D-NMR techniques. Compounds 1 was tested for their cytotoxicity against five human tumor cell lines, NB4, A549, SHSY5Y, PC3 and MCF7 and it showed potential cytotoxicity against A549 and MCF7 cell lines with IC50 values of 5.8 and 6.2 μM, respectively.

Keywords

Desmodium renifolium Prenylated chalcone Cytotoxicity
Lou, J., Liu, G.-Y., Wang, H., Yang, J.-X., Li, L., Hu, Q.-F., … Gao, X.-M. (2014). A New Cytotoxic Prenylated Chalcone from Desmodium renifolium. Asian Journal of Chemistry, 26(21), 7165–7167. https://doi.org/10.14233/ajchem.2014.16538
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