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A New Isoprenylated Aurone from the Flowers of Rosa damascene and Its Cytotoxicities
Corresponding Author(s) : Xue-Mei Gao
Asian Journal of Chemistry,
Vol. 26 No. 21 (2014): Vol 26 Issue 21
Abstract
A phytochemical investigation of the flowers of Rosa damascena resulted in the isolation of a new isoprenylated aurone (Z)-2-(4-methoxybenzylidene)-7,7-dimethyl-7,8-dihydro-2H-furo[2,3-f]chromene-3,9-dione (1), Its structure was elucidated by spectroscopic methods, including extensive 1D- and 2D- NMR experiments. Compounds 1 was tested for their cytotoxicities against five human tumor cell lines, NB4, A549, SHSY5Y, PC3 and MCF7 and it showed potential cytotoxicity against NB4 and SHSY5Y cell lines with IC50 values of 4.8 and 3.4 μM, respectively.
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- S. Ercisli, Food Chem., 104, 1379 (2007); doi:10.1016/j.foodchem.2007.01.053.
- K. Shibata, A Cyclopedia of Useful Plant and Plant Products: Enlarged and Revised Edition, The Hokuryukan, Tokyo, p. 612 (1957).
- Y. Jiang, Flora of China, Chinese Science Press: Beijing (1977).
- X. Gao, G. Du, Q. Hu, D. Niu, S. Yang, H. Cao, C. Meng and H. Yang, Heterocycles, 87, 2103 (2013); doi:10.3987/COM-13-12798.
- N. Kumar, B. Singh and V.K. Kaul, Nat. Prod. Commun., 623, 1 (2006); A. Shieber, K. Mihalev, N. Berardini, P. Mollov and R. Carle, Z. Naturforsch. C, 60, 379 (2005).
- Y.-S. Velioglu and G. Mazza, J. Agric. Food Chem., 39, 463 (1991); doi:10.1021/jf00003a007; M. Jalali-Heravi, H. Parastar and H. Sereshti, Anal. Chim. Acta, 623, 11 (2008); doi:10.1016/j.aca.2008.05.078.
- H.-J. Kim, K. Kim, N.-S. Kim and D.-S. Lee, J. Chromatogr. A, 902, 389 (2000); doi:10.1016/S0021-9673(00)00863-3; J. Cai, J. Xing, M. Sun, Z.-Q. Zhan and H. Corke, J. Agric. Food Chem., 53, 9940 (2005); doi:10.1021/jf052137k..
- P.-K. Agrawal, Carbon-13 NMR of Flavonoids, Elsevier, Amsterdam, p. 564 (1989).
- X.-M. Gao, R.-R. Wang, D.-Y. Niu, C.-Y. Meng, L.-M. Yang, Y.-T. Zheng, G.-Y. Yang, Q.-F. Hu, H.-D. Sun and W.-L. Xiao, J. Nat. Prod., 76, 1052 (2013); doi:10.1021/np400070x.
References
S. Ercisli, Food Chem., 104, 1379 (2007); doi:10.1016/j.foodchem.2007.01.053.
K. Shibata, A Cyclopedia of Useful Plant and Plant Products: Enlarged and Revised Edition, The Hokuryukan, Tokyo, p. 612 (1957).
Y. Jiang, Flora of China, Chinese Science Press: Beijing (1977).
X. Gao, G. Du, Q. Hu, D. Niu, S. Yang, H. Cao, C. Meng and H. Yang, Heterocycles, 87, 2103 (2013); doi:10.3987/COM-13-12798.
N. Kumar, B. Singh and V.K. Kaul, Nat. Prod. Commun., 623, 1 (2006); A. Shieber, K. Mihalev, N. Berardini, P. Mollov and R. Carle, Z. Naturforsch. C, 60, 379 (2005).
Y.-S. Velioglu and G. Mazza, J. Agric. Food Chem., 39, 463 (1991); doi:10.1021/jf00003a007; M. Jalali-Heravi, H. Parastar and H. Sereshti, Anal. Chim. Acta, 623, 11 (2008); doi:10.1016/j.aca.2008.05.078.
H.-J. Kim, K. Kim, N.-S. Kim and D.-S. Lee, J. Chromatogr. A, 902, 389 (2000); doi:10.1016/S0021-9673(00)00863-3; J. Cai, J. Xing, M. Sun, Z.-Q. Zhan and H. Corke, J. Agric. Food Chem., 53, 9940 (2005); doi:10.1021/jf052137k..
P.-K. Agrawal, Carbon-13 NMR of Flavonoids, Elsevier, Amsterdam, p. 564 (1989).
X.-M. Gao, R.-R. Wang, D.-Y. Niu, C.-Y. Meng, L.-M. Yang, Y.-T. Zheng, G.-Y. Yang, Q.-F. Hu, H.-D. Sun and W.-L. Xiao, J. Nat. Prod., 76, 1052 (2013); doi:10.1021/np400070x.