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Preparation and Characterization of Blood Substitutes Based on Amphiphilic Biodegradable Copolymers
Corresponding Author(s) : Yanjun Gao
Asian Journal of Chemistry,
Vol. 26 No. 21 (2014): Vol 26 Issue 21
Abstract
A biodegradable hemoglobin nanoparticles based on the copolymers of MPEG-b-PLA was prepared by self-assemble. The optimization conditions were obtained that the hemoglobin was encapsulated in the polymersomes. The hemoglobin nanoparticles with different states encapsulated in the polymersomes can be mutual transformed under different gas atmosphere was observed by UV spectra. While the oxygen partial pressure was increased, the oxy-hemoglobin was gradually transformed from deoxy-hemoglobin.
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- H. Sakai, K. Sou, H. Horinouchi, K. Kobayashi and E. Tsuchida, Artif. Organs, 33, 139 (2009); doi:10.1111/j.1525-1594.2008.00698.x.
- A.I. Alayash, Nat. Biotechnol., 17, 545 (1999); doi:10.1038/9849.
- L. Brander, A. Reil, J. Bux, B.M. Taleghani, B. Regli and J. Takala, Anesth. Analg., 101, 499 (2005); doi:10.1213/01.ANE.0000159375.26910.9C.
- A.W. Sellards and G.R. Minot, J. Med. Res., 34, 469 (1916).
- W.R. Amberson, A.G. Mulder, F.R. Steggerda, J. Flexner and D.S. Pankratz, Science, 78, 106 (1933); doi:10.1126/science.78.2014.106.
- W.R. Amberson, J.J. Jennings and C.M. Rhode, J. Appl. Physiol., 1, 469 (1949).
- B. Li, G. Chen, F.B. Meng, T.H. Li, J. Yue, X.B. Jing and Y.B. Huang, Polym. Chem., 3, 2421 (2012); doi:10.1039/c2py20253k.
- H. Agashe, P. Lagisetty, S. Awasthi and V. Awasthi, Colloids Surf. B, 75, 573 (2010); doi:10.1016/j.colsurfb.2009.09.038.
- B. Li, T.H. Li, G. Chen, X.Y. Li, L.S. Yan, Z.G. Xie, X.B. Jing and Y.B. Huang, Macromol. Biosci., 13, 893 (2013); doi:10.1002/mabi.201300012.
- E.J. van Kampen and W.G. Zijlstra, Adv. Clin. Chem., 23, 199 (1983); doi:10.1016/S0065-2423(08)60401-1.
References
H. Sakai, K. Sou, H. Horinouchi, K. Kobayashi and E. Tsuchida, Artif. Organs, 33, 139 (2009); doi:10.1111/j.1525-1594.2008.00698.x.
A.I. Alayash, Nat. Biotechnol., 17, 545 (1999); doi:10.1038/9849.
L. Brander, A. Reil, J. Bux, B.M. Taleghani, B. Regli and J. Takala, Anesth. Analg., 101, 499 (2005); doi:10.1213/01.ANE.0000159375.26910.9C.
A.W. Sellards and G.R. Minot, J. Med. Res., 34, 469 (1916).
W.R. Amberson, A.G. Mulder, F.R. Steggerda, J. Flexner and D.S. Pankratz, Science, 78, 106 (1933); doi:10.1126/science.78.2014.106.
W.R. Amberson, J.J. Jennings and C.M. Rhode, J. Appl. Physiol., 1, 469 (1949).
B. Li, G. Chen, F.B. Meng, T.H. Li, J. Yue, X.B. Jing and Y.B. Huang, Polym. Chem., 3, 2421 (2012); doi:10.1039/c2py20253k.
H. Agashe, P. Lagisetty, S. Awasthi and V. Awasthi, Colloids Surf. B, 75, 573 (2010); doi:10.1016/j.colsurfb.2009.09.038.
B. Li, T.H. Li, G. Chen, X.Y. Li, L.S. Yan, Z.G. Xie, X.B. Jing and Y.B. Huang, Macromol. Biosci., 13, 893 (2013); doi:10.1002/mabi.201300012.
E.J. van Kampen and W.G. Zijlstra, Adv. Clin. Chem., 23, 199 (1983); doi:10.1016/S0065-2423(08)60401-1.