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Vol. 26 No. 21 (2014): Vol 26 Issue 21

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Green Synthesis, Physicochemical and Polarity Studies of Some Novel Biologically Active Donor Acceptor Chromophores

https://doi.org/10.14233/ajchem.2014.16866
Salman A. Khan
Department of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia
Abdullah M. Asiri
Department of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia ; Center of Excellence for Advanced Materials Research (CEAMR), King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia
Samy A. El-Daly
Department of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia; Chemistry Department, Faculty of Science, Tanta University, Tanta, Egypt
Hadi M. Marwani
Department of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia ; Center of Excellence for Advanced Materials Research (CEAMR), King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia
Khalid A. Alamry
Department of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia

Corresponding Author(s) : Salman A. Khan

sahmad_phd@yahoo.co.in

Asian Journal of Chemistry, Vol. 26 No. 21 (2014): Vol 26 Issue 21

Abstract

Chalcones were synthesized by the reaction of acetyl ferrocene and corresponding aldehhyde under microwave irradiation. Results obtained from spectroscopic (FT-IR, 1H NMR, 13C NMR, EI-MS) and elemental analysis of synthesized compounds was in agreement with their chemical structures. UV-visible and fluorescence spectroscopy measurements provided that compound 1 and 2 are good absorbent and fluorescent. Fluorescence polarity study demonstrated that these compounds were sensitive to the polarity of the microenvironment provided by different solvents. In addition, spectroscopic and physicochemical parameters, including electronic absorption, extenction coefficient, Stokes shift, oscillator strength and transition dipole moment, were investigated in order to explore the analytical potential of synthesized compounds. The antibacterial activity of the compound 1 and 2 were first studied in vitro by the disk diffusion assay against two Gram-positive and two Gram-negative bacteria. The minimum inhibitory concentration was then determined with the reference of standard drug chloramphenicol.

Keywords

Chalcones Physicochemical Antibacterial activity Chloramphenicol
A. Khan, S., M. Asiri, A., A. El-Daly, S., M. Marwani, H., & A. Alamry, K. (2014). Green Synthesis, Physicochemical and Polarity Studies of Some Novel Biologically Active Donor Acceptor Chromophores. Asian Journal of Chemistry, 26(21), 7364–7368. https://doi.org/10.14233/ajchem.2014.16866
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