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Vol. 26 No. 21 (2014): Vol 26 Issue 21

Copyright (c) 2014 AJC

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Synthesis and Biological Evaluation of a Benz[cd]indol-2(1H)-one Derivatives

https://doi.org/10.14233/ajchem.2014.16729
Jing Nie
School of Material Science and Chemical Engineering, Tianjin University of Science and Technology, Tianjin 300457, P.R. China
Dan-Dan Dong
College of Pharmacy, NanKai University, Tianjin 300071, P.R. China
Yan Zhang
College of Life Sciences, NanKai University, Tianjin 300071, P.R. China
Tai-Yi Wang
College of Life Sciences, NanKai University, Tianjin 300071, P.R. China
Wei Liu
College of Sciences, Tianjin University of Science and Technology, Tianjin 300457, P.R. China
Shou-Zhi Yi
School of Material Science and Chemical Engineering, Tianjin University of Science and Technology, Tianjin 300457, P.R. China

Corresponding Author(s) : Shou-Zhi Yi

yshzh@tust.edu.cn

Asian Journal of Chemistry, Vol. 26 No. 21 (2014): Vol 26 Issue 21

Abstract

Virtual screening of a library of 6.4 million compounds versus the structure of Xenopus Laevis' Aurora B kinase identified 1-(n-propyl)-6-[2-(carboxyl)tetrahydropyrrol-1-yl]sulfonyl-benzo[cd]indol-2(1H)-one 1 as a possible lead compound. Then, a novel series of benz[cd]indol-2(1H)-one derivatives were synthesized and evaluated as Aurora B kinase inhibitors. The structures of the synthetic compounds were confirmed by 1H NMR, IR, mass spectrometry and elemental analysis. These compounds were evaluated by in vitro enzyme assay using spectrophotometry. Among them, compound 7e displayed potent antitumor activity against Aurora B kinase.

Keywords

Aurora B Kinase inhibitor Benz[cd]indol-2(1H)-one derivatives
Nie, J., Dong, D.-D., Zhang, Y., Wang, T.-Y., Liu, W., & Yi, S.-Z. (2014). Synthesis and Biological Evaluation of a Benz[cd]indol-2(1H)-one Derivatives. Asian Journal of Chemistry, 26(21), 7329–7336. https://doi.org/10.14233/ajchem.2014.16729
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