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Vol. 38 No. 3 (2026): Vol 38 Issue 3, 2026

Copyright (c) 2026 Maria Carmen Tan, Virgilio Linis, Mary Stephanie Carranza, Glenn Oyong

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Exploring Anti-Inflammatory Drug Leads from Caesalpinia pulcherrima (L.) Sw. (Fabaceae) Through Bibliometric and Computational Approaches

https://doi.org/10.14233/ajchem.2026.35271
M.C. Tan
Department of Chemistry, De La Salle University, 2401 Taft Avenue, Malate, Manila 0922, Philippines
https://orcid.org/0000-0003-4413-5460
V. Linis
Benilde Senior High School, De La Salle-College of Saint Benilde, 2544 Taft Avenue, Malate, Manila 0922, Philippines
https://orcid.org/0000-0001-6940-8627
M.S. Carranza
Department of Chemistry, De La Salle University, 2401 Taft Avenue, Malate, Manila 0922, Philippines
https://orcid.org/0000-0001-9717-0062
G. Oyong
Department of Physics, De La Salle University, 2401 Taft Avenue, Malate, Manila 0922, Philippines
https://orcid.org/0000-0001-8224-9034

Corresponding Author(s) : M.C. Tan

maria.carmen.tan@dlsu.edu.ph

Asian Journal of Chemistry, Vol. 38 No. 3 (2026): Vol 38 Issue 3, 2026

Abstract

This study integrated a bibliometric technique to chart the landscape of international research on Caesalpinia pulcherrima (L.) Sw. (Fabaceae). To further substantiate the utilisation of C. pulcherrima, in silico analyses was employed to explore prospective phytochemicals found in C. pulcherrima as novel inhibitors of NF-κB p50 subunit, a key mediator of inflammation involved in several debilitating conditions including cardiovascular and respiratory diseases, diabetes, cancer and autoimmune disorders. Bibliometric mapping revealed a concentrated global research landscape, led by India and Brazil, with high-impact collaborations centered in Europe. Molecular docking identified bonducellin (9) as a top candidate, exhibiting a superior binding affinity (-3.9 kcal/mol) compared to standard drug dexamethasone (1) (-3.7 kcal/mol). Two other phytochemicals, galactomannan (2) and 5,7-dimethoxyflavone (8), inherent in C. pulcherrima also gave promising binding energies. Pharmacokinetic profiling indicated promising drug-likeness and blood-brain barrier penetration for several flavonoids. These results support the traditional anti-inflammatory use of C. pulcherrima and highlight bonducellin as a potential lead molecule for targeted therapeutic development, requiring further experimental and clinical validation.

Keywords

Caesalpinia pulcherrima Bibliometric analysis In silico molecular simulations Binding energy NF-κB p50 subunit
(1)
Tan, M.; Linis, V.; Carranza, M.; Oyong, G. Exploring Anti-Inflammatory Drug Leads from Caesalpinia Pulcherrima (L.) Sw. (Fabaceae) Through Bibliometric and Computational Approaches. ajc 2026, 38, 691-704.
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References
  1. A.B.F. Carrington-Dyall, A.I. Shekaib and N.E. Clarke-Jordan, J. Med. Res., 7, 152 (2020); https://doi.org/10.24041/ejmr2020.26
  2. J.Y. Ng, BMC Complement. Med. Ther., 20, 353 (2020); https://doi.org/10.1186/s12906-020-03151-8
  3. K. Jaikumar, M.S.N. Mohamed, W.J. Wyson, M. Deventhiran, D. Anand and P. Saravanan, Int. J. Pharm. Sci. Drug Res., 9, 90 (2017); https://doi.org/10.25004/IJPSDR.2017.090209
  4. C.M.L. de Melo, I.J. da Cruz Filho, G.F. de Sousa, G.A. de Souza Silva, D.K.D. do Nascimento Santos, R.S. da Silva, B.R. de Sousa, R.G. de Lima Neto, M. do Carmo Alves de Lima and G.J. de Moraes Rocha, Int. J. Biol. Macromol., 162, 1725 (2020); https://doi.org/10.1016/j.ijbiomac.2020.08.003
  5. N. Bhagya, South Afr. J. Bot., 174, 796 (2024); https://doi.org/10.1016/j.sajb.2024.09.031
  6. M.R. Kumbhare, T. Sivakumar, P.B. Udavant, A.S. Dhake and A.R. Surana, Pak. J. Biol. Sci., 15, 325 (2012); https://doi.org/10.3923/pjbs.2012.325.332
  7. L.C. Chiang, W. Chiang, M.C. Liu and C.C. Lin, J. Antimicrob. Chemother., 52, 194 (2003); https://doi.org/10.1093/jac/dkg291
  8. C. Rajaram, K.R. Reddy and K.B.C. Sekhar, J. Young Pharm., 7, 128 (2015); https://doi.org/10.5530/jyp.2015.2.12
  9. N.A. Thombre and P.S. Gide, Turk. J. Pharm. Sci., 12, 9 (2015).
  10. A.O. Ogunbinu, S. Okeniyi, G. Flamini, P.L. Cioni and I.A. Ogunwande, J. Essential Oils, 22, 536 (2010); https://doi.org/10.1080/10412905.2010.9700393
  11. K.V. Srinivas, Y. Koteswara Rao, I. Mahender, B. Das, K.V. Rama Krishna, K.H. Kishore and U.S. Murty, Phytochemistry, 63, 789 (2003); https://doi.org/10.1016/S0031-9422(03)00325-X
  12. N. Promsawan, P. Kittakoop, S. Boonphong and P. Nongkunsarn, Planta Med., 69, 776 (2003); https://doi.org/10.1055/s-2003-42782
  13. W. Pranithanchai, C. Karalai, C. Ponglimanont, S. Subhadhirasakul and K. Chantrapromma, Phytochemistry, 70, 300 (2009); https://doi.org/10.1016/j.phytochem.2008.12.006
  14. O. Yodsaoue, C. Karalai, C. Ponglimanont, S. Tewtrakul and S. Chantrapromma, Tetrahedron, 67, 6838 (2011); https://doi.org/10.1016/j.tet.2011.06.087
  15. O. Erharuyi, A. Adhikari, A. Falodun, A. Jabeen, R. Imad, M. Ammad, M.I. Choudhary and N. Goren, Planta Med., 83, 104 (2016); https://doi.org/10.1055/s-0042-110407
  16. Y.K. Rao, S.-H. Fang and Y.-M. Tzeng, J. Ethnopharmacol., 100, 249 (2005); https://doi.org/10.1016/j.jep.2005.02.039
  17. N.J. van Eck and L. Waltman, Scientometrics, 84, 523 (2010); https://doi.org/10.1007/s11192-009-0146-3
  18. H.M. Berman, J. Westbrook, Z. Feng, G. Gilliland, T.N. Bhat, H. Weissig, I.N. Shindyalov and P.E. Bourne, Nucleic Acids Res., 28, 235 (2000); https://doi.org/10.1093/nar/28.1.235
  19. Dassault Systèmes, BIOVIA Discovery Studio Visualizer, version 21.2, Dassault Systèmes (2021).
  20. G.M. Morris, R. Huey, W. Lindstrom, M.F. Sanner, R.K. Belew, D.S. Goodsell and A.J. Olson, J. Comput. Chem., 30, 2785 (2009); https://doi.org/10.1002/jcc.21256
  21. S. Kim, J. Chen, T. Cheng, A. Gindulyte, J. He, S. He, B.A. Shoemaker, Q. Li, P.A. Thiessen, B. Yu, L. Zaslavsky, J. Zhang and E.E. Bolton, Nucleic Acids Res., 51(D1), D1373 (2023); https://doi.org/10.1093/nar/gkac956
  22. O. Trott and A.J. Olson, J. Comput. Chem., 31, 455 (2010); https://doi.org/10.1002/jcc.21334
  23. A. Daina, O. Michielin and V. Zoete, Sci. Rep., 7, 42717 (2017); https://doi.org/10.1038/srep42717
  24. C.A. Lipinski, F. Lombardo, B.W. Dominy and P.J. Feeney, Adv. Drug Deliv. Rev., 46, 3 (2001); https://doi.org/10.1016/S0169-409X(00)00129-0
  25. A. Adewuyi and R.A. Oderinde, Int. J. Food Sci., 2014, 283614 (2014); https://doi.org/10.1155/2014/283614
  26. I. Muegge, S.L. Heald and D. Brittelli, J. Med. Chem., 44, 1841 (2001); https://doi.org/10.1021/jm015507e
  27. F.C.A. Buriti, K.M.O. dos Santos, V.G. Sombra, J.S. Maciel, D.M.A. Teixeira Sá, H.O. Salles, G. Oliveira, R.C.M. de Paula, J.P.A. Feitosa, A.C.O. Monteiro Moreira, R.A. Moreira and A.S. Egito, Food Hydrocoll., 35, 512 (2014); https://doi.org/10.1016/j.foodhyd.2013.07.015
  28. M.M. Alves, E.U. Alves, L.R. Araújo and M.L.S. Lima, Cienc. Rural, 47, e20150433 (2017); https://doi.org/10.1590/0103-8478cr20150433
  29. M.M. Alves, E.U. Alves, L.R. Araújo, M.L.S. Lima and M.M. Ursulino, Cienc. Rural, 48, e20170741 (2018); https://doi.org/10.1590/0103-8478cr20170741
  30. A.M.O. Amoussa, L. Lagnika, V. Jullian and F. Chassagne, Biomed. Pharmacother., 158, 114119 (2023); https://doi.org/10.1016/j.biopha.2022.114119
  31. S.R. AnandaKumar, V.P. Veerapur, M. Roopesh, M.V. Ambika, S. Babitha and B.S. Thippeswamy, Heliyon, 10, e39774 (2024); https://doi.org/10.1016/j.heliyon.2024.e39774
  32. P.S. Anusree Padmanabhan and M. Chellappan, Indian J. Entomol., 84, 38 (2022); https://doi.org/10.55446/IJE.2021.339
  33. A. Anwar, E.L.S. Ting, A. Anwar, N. Ain, S. Faizi, M.R. Shah, N.A. Khan and R. Siddiqui, AMB Express, 10, 24 (2020); https://doi.org/10.1186/s13568-020-0960-9
  34. S.R.A. Arcanjo-Medeiros, V.A.A.M.C. de Oliveira and M.L.H. de Oliveira, Ciencia Rural, 50, e20190176 (2020); https://doi.org/10.1590/0103-8478cr20190176
  35. L.E. Argulla and C.L. Chichioco-Hernandez, Asian Pac. J. Trop. Dis., 4, 438 (2014); https://doi.org/10.1016/S2222-1808(14)60602-2
  36. E.V. Blynskaya, S.V. Tishkov, V.P. Vinogradov, K.V. Alekseev, A.I. Marakhova and A.A. Vetcher, Pharmaceutics, 14, 2779 (2022); https://doi.org/10.3390/pharmaceutics14122779
  37. H.P. Borase and D. Shukla, Viruses, 15, 2195 (2023); https://doi.org/10.3390/v15112195
  38. R.C. Braga, D.M.A. Teixeira-Sá, A.F. Ribeiro, R.L. Miranda, L.M. Almeida, A.C.G. Horta and R.A. Moreira, Braz. Arch. Biol. Technol., 54, 283 (2011); https://doi.org/10.1590/S1516-89132011000200009
  39. U.B. Breitbach, M. Niehues, N.P. Lopes, J.E.Q. Faria and M.G.L. Brandão, J. Ethnopharmacol., 147, 180 (2013); https://doi.org/10.1016/j.jep.2013.02.030
  40. M.A. Cerqueira, B.W.S. Souza, J.A. Teixeira, M.R.M. Domingues, J. Simões, M.A. Coimbra and A.A. Vicente, Carbohydr. Polym., 83, 179 (2011); https://doi.org/10.1016/j.carbpol.2010.07.036
  41. M.A. Cerqueira, A.C. Pinheiro, B.W.S. Souza, Á.M.P. Lima, C. Ribeiro, C. Miranda, J.A. Teixeira, R.A. Moreira, M.A. Coimbra, M.P. Gonçalves and A.A. Vicente, Carbohydr. Polym., 75, 408 (2009); https://doi.org/10.1016/j.carbpol.2008.07.036
  42. X.-M. Chen, W. Lu, Z. Zhang, J.-Y. Zhang, T.M.L. Tuong, L.-L. Liu, Y.H. Kim, C.-H. Li and J.-M. Gao, Phytochemistry, 196, 113082 (2022); https://doi.org/10.1016/j.phytochem.2021.113082
  43. J. Cheng, J.S. Roach, S. McLean, W.F. Reynolds and W.F. Tinto, Nat. Prod. Commun., 3, 1751 (2008); https://doi.org/10.1177/1934578X0800301102
  44. Y.L. Chew, E.W. Ling Chan, P.L. Tan, Y.Y. Lim, J. Stanslas and J.K. Goh, BMC Complement. Altern. Med., 11, 12 (2011); https://doi.org/10.1186/1472-6882-11-12
  45. A.K. Costa, J. Senna, L. Cardoso, L.C. Palermo and C. Mansur, Brazilian J. Anal. Chem., 9, 94 (2022); https://doi.org/10.30744/brjac.2179-3425.AR-21-2022
  46. N.G. Fonseca and C.M. Jacobi, Acta Bot. Bras., 25, 191 (2011); https://doi.org/10.1590/S0102-33062011000100022
  47. P. Das, D. Mitra, K. Jana and D. Ghosh, Reprod. Sci., 30, 3480 (2023); https://doi.org/10.1007/s43032-023-01327-4
  48. D.D. Deeb and X. Gao, J. Exp. Ther. Oncol., 7, 31 (2008).
  49. C.M.L. Melo, G.F. Sousa, G.A.S. Silva, R.S. Silva, N.S. Bezerra Júnior, D.K.D.N. Santos, M.C.A. Lima and I.J. Cruz Filho, Braz. Arch. Biol. Technol., 65, e22200718 (2022); https://doi.org/10.1590/1678-4324-2022200718
  50. G.L.T. Dela Torre, E.C. Arollado, A.A. Atienza and R.A.M. Manalo, Indian J. Pharm. Sci., 79, 113 (2017); https://doi.org/10.4172/pharmaceutical-sciences.1000207
  51. P.O. Deshpande and A.K. Tiwari, EXCLI J., 15, 446 (2016); https://doi.org/10.17179/excli2016-510
  52. D. Dhingra and Deepak, Braz. J. Pharm. Sci., 57, e18891 (2021); https://doi.org/10.1590/s2175-97902020000418891
  53. P.L.F. Dos Santos, R.M.M. de Castilho and R.R. Pinheiro, Ornam. Hortic., 25, 119 (2019); https://doi.org/10.14295/oh.v25i2.1727
  54. V.R.F. Dos Santos, B.W.S. Souza, J.A. Teixeira, A.A. Vicente and M.A. Cerqueira, J. Food Sci. Technol., 52, 8292 (2015); https://doi.org/10.1007/s13197-015-1961-6
  55. V. Dougnon, B.B. Legba, B. Gbaguidi, E. Agbodjento, A.J. Agbankpè, D. Rocha, I. Ayi, S. Azonbakin, A. Diallo, I.J. Bonkoungou, J.R. Klotoé, C. Agbangla and G.A. Alitonou, Int. J. One Health, 8, 124 (2022); https://doi.org/10.14202/IJOH.2022.124-160
  56. M.R. Flores-Ocelotl, N.H. Rosas-Murrieta, D.A. Moreno, V. Vallejo-Ruíz, J. Reyes-Leyva, F. Dominguez and G. Santos-López, BMC Complement. Altern. Med., 18, 95 (2018); https://doi.org/10.1186/s12906-018-2163-3
  57. H.-K. Fun, O. Yodsaoue, S. Chantrapromma and C. Karalai, Acta Crystallogr. Sect. E Struct. Rep. Online, 66, o2166 (2010); https://doi.org/10.1107/S1600536810029557
  58. H.-K. Fun, O. Yodsaoue, C. Karalai and S. Chantrapromma, Acta Crystallogr. Sect. E Struct. Rep. Online, 66, o2059 (2010); https://doi.org/10.1107/S1600536810028023
  59. I. Ganai, I. Saha, P. Banerjee, A. Laha, S. Sultana, N. Sultana, H. Biswas, S. Moitra and S. Podder, Front. Immunol., 14, 1089514 (2023); https://doi.org/10.3389/fimmu.2023.1089514
  60. M. Govindarajan, T. Mathivanan, K. Elumalai, K. Krishnappa and A. Anandan, Asian Pac. J. Trop. Biomed., 1, 43 (2011); https://doi.org/10.1016/S2221-1691(11)60066-X
  61. G.N. Handayany and M.T. Cahya, Indian J. Public Health Res. Dev., 10, 1130 (2019); https://doi.org/10.5958/0976-5506.2019.00242.0
  62. F.-L. Hsu, W.-J. Huang, T.-H. Wu, M.-H. Lee, L.-C. Chen, H.-J. Lu, W.-C. Hou and M.-H. Lin, Int. J. Mol. Sci., 13, 6073 (2012); https://doi.org/10.3390/ijms13056073
  63. Y.-S. Huang, F.-D. Wang, Y.-C. Chen, Y.-T. Huang, M.-H. Hsieh, I.M. Hii, Y.-L. Lee, M.-W. Ho, C.-E. Liu, Y.-H. Chen and W.-L. Liu, J. Formos. Med. Assoc., 120, 1179 (2021); https://doi.org/10.1016/j.jfma.2020.11.002
  64. S. Jeevanandham, D. Dhachinamoorthi, V. Senthil and S.K.B. Chandra, Asian J. Pharm., 4, 135 (2010); https://doi.org/10.4103/0973-8398.68465
  65. K. Singh and B. Verma, Int. J. Res. Ayurveda Pharm., 4, 589 (2013); https://doi.org/10.7897/2277-4343.04428
  66. S.A. Khan and K. Al Balushi, J. Infect. Public Health, 14, 495 (2021); https://doi.org/10.1016/j.jiph.2020.10.012
  67. G.R. Kirana, A.A. Wibowo, E. Nurdin, W. Wardhana and A. Basukriadi, Asian J. For., 7, 75 (2023); https://doi.org/10.13057/asianjfor/r07020
  68. P. Kola, K. Metowogo, Y.T. Kantati, P. Lawson-Evi, M. Kpemissi, S.M. El-Hallouty, A.P. Mouzou, K. Eklu-Gadegbéku and K.A. Aklikokou, Evid. Based Complement. Alternat. Med., 2020, 6940132 (2020); https://doi.org/10.1155/2020/6940132
  69. K. Kropi, K.P. Jastone, S.A. Kharumnuid, H. Kumar Das and M.M. Naga, J. Ayurveda Integr. Med., 15, 101024 (2024); https://doi.org/10.1016/j.jaim.2024.101024
  70. R. Kumar, O.K. Ogbeide, Mujeeb-Ur-Rehman, B. Owolabi, A. Falodun, M.I. Choudhary and S. Yousuf, Acta Crystallogr. E Crystallogr. Commun., 75, 119 (2019); https://doi.org/10.1107/S2056989018017498
  71. S. Kumar, J. Singh, A. Baghotia, V. Mehta, V. Thakur, M. Choudhary, S. Verma and D. Kumar, Asian Pac. J. Reprod., 2, 90 (2013); https://doi.org/10.1016/S2305-0500(13)60125-6
  72. J. Kusmoro, B. Mayawatie, R. Budiono, I.S. Noer, R.E. Permatasari, A. Nurwahidah, R. Satriawati, D. Arum, D.E. Saragih, R.I.A. Widya, M.F. Jatnika, A. Makarim and R. Partasasmita, Biodiversitas, 20, 1606 (2019); https://doi.org/10.13057/biodiv/d200617
  73. Á.M. Lima, M.A. Cerqueira, B.W.S. Souza, E.C.M. Santos, J.A. Teixeira, R.A. Moreira and A.A. Vicente, J. Food Eng., 97, 101 (2010); https://doi.org/10.1016/j.jfoodeng.2009.09.021
  74. M.S. Liman, A. Hassen, L.J. McGaw, P. Šutovský and D.E. Holm, Animals, 12, 1130 (2022); https://doi.org/10.3390/ani12091130
  75. P. Lohar, D. Pal, T. Mondal, P. Das and D. Ghosh, JBRA Assist. Reprod., 29, 76 (2024); https://doi.org/10.5935/1518-0557.20240085
  76. A.J. Madanakumar, G. Murukan, B. Lawarence and M. Kumaraswamy, Pharmacogn. J., 9(6s), s44 (2017); https://doi.org/10.5530/pj.2017.6s.156
  77. M. Maheswara, V. Siddaiah and C. Venkata Rao, Chem. Pharm. Bull., 54, 1193 (2006); https://doi.org/10.1248/cpb.54.1193
  78. S. Mandal, Asian Pac. J. Trop. Biomed., 2, 336 (2012); https://doi.org/10.1016/S2221-1691(12)60035-5
  79. D.R.A. Mans, J.R. Toelsie, Z. Jagernath, K. Ramjiawan, A. van Brussel, N. Jhanjan, S. Orie, M. Muringen, U. Elliot, S. Jurgens, R. Macnack, F. Rigters, S. Mohan, V. Chigharoe, S. Illes and R. Bipat, Pharm. Biol., 42, 422 (2004); https://doi.org/10.1080/13880200490886012
  80. D.R.A. Mans, J.R. Toelsie, K. Oedairadjs, I. Magali, R. Soekhoe and R. Bipat, Res. J. Med. Plant, 9, 14 (2015); https://doi.org/10.3923/rjmp.2015.14.23
  81. C.R. Marinho, M.E.P. Martucci, L. Gobbo-Neto and S.P. Teixeira, Bot. J. Linn. Soc., 187, 5 (2018); https://doi.org/10.1093/botlinnean/boy002
  82. F.C.J. Marques, F.G.S. Nascimento, D.T.T. Nonato, A.M.S. Assreuy, E.M.C. Chaves, G.F. Aragão, P.M.G. Soares and R.R. Castro, Rev. Caatinga, 38, e12704 (2025); https://doi.org/10.1590/1983-21252025v3812704rc
  83. C.D. Mathers and D. Loncar, PLoS Med., 3, e442 (2006); https://doi.org/10.1371/journal.pmed.0030442
  84. S. Mehmood, N. Kausar Janjua, S. Tabassum, S. Faizi and H. Fenniri, Results Chem., 4, 100437 (2022); https://doi.org/10.1016/j.rechem.2022.100437
  85. H. Min and J.Y. Lee, Exp. Mol. Med., 54, 1670 (2022); https://doi.org/10.1038/s12276-022-00864-3
  86. F.M. Moreira, C.S. Braulio, Â.S.J.C. Anjos, J.J. Silva, J.M.A. Rocabado and R.S.A. Nóbrega, Rev. Arvore, 46, e4634 (2022); https://doi.org/10.1590/1806-908820220000034
  87. P. Moteriya and S. Chanda, J. Genet. Eng. Biotechnol., 16, 105 (2018); https://doi.org/10.1016/j.jgeb.2017.12.003
  88. P. Moteriya and S. Chanda, J. Inorg. Organomet. Polym. Mater., 30, 3920 (2020); https://doi.org/10.1007/s10904-020-01532-7
  89. J. Mottaghipisheh and H. Stuppner, Int. J. Mol. Sci., 22, 2735 (2021); https://doi.org/10.3390/ijms22052735
  90. L.H.E. Mourão, F.R. da Silva Mendes, F.D. de Sousa, A.C. de Oliveira Monteiro-Moreira, S.R.A. Medeiros, M. do S. Rocha Bastos, G.D. Saraiva, A.M.R. Teixeira and R. de Azevedo Moreira, J. Food Process. Preserv., 2023, 8893925 (2023); https://doi.org/10.1155/2023/8893925
  91. N. Mukhopadhyay, V. Sampath, S. Pai, U.V. Babu and R. Lobo, Res. J. Pharm. Technol., 12, 375 (2019); https://doi.org/10.5958/0974-360X.2019.00068.4
  92. D. Nigussie, E. Makonnen, T.B. Tufa, M. Brewster, B.A. Legesse, A. Fekadu and G. Davey, J. Ethnopharmacol., 276, 114179 (2021); https://doi.org/10.1016/j.jep.2021.114179
  93. C.O. Nnadi, N.H. Okorie, N.J. Nwodo and N.J. Tropical, J. Nat. Prod. Res., 5, 609 (2021); https://doi.org/10.26538/tjnpr/v5i4.2
  94. O.K. Ogbeide, I.U. Akhigbe, C.A. Unuigbe, O. Erharuyi and V. Imieje, Tropical J. Nat. Prod. Res., 5, 2011 (2021); https://doi.org/10.26538/tjnpr/v5i11.20
  95. O. Ogbeide, V. Dickson, R. Jebba, D. Owhiroro, M. Olaoluwa, B. Owolabi, V. Imieje, A. Falodun and P. Fasinu, Trop. J. Nat. Prod. Res., 2, 179 (2018); https://doi.org/10.26538/tjnpr/v2i4.5
  96. O.K. Ogbeide, R. Kumar, B. Mujeeb-Ur-Rehman, B. Owolabi, A. Falodun, M.I. Choudhary and S. Yousuf, Acta Crystallogr. E Crystallogr. Commun., 74, 385 (2018); https://doi.org/10.1107/S2056989018002499
  97. O.K. Ogbeide, J. Mujeeb-Ur-Rehman, J.B. Owolabi, A. Falodun, M.I. Choudhary and S. Yousuf, Acta Crystallogr. E Crystallogr. Commun., 73, 1572 (2017); https://doi.org/10.1107/S2056989017011239
  98. K. Oriakhi, O. Erharuyi, K.O. Orumwensodia, E.E. Essien, A. Falodun, P.O. Uadia, F. Bernhard and N. Engel, Toxicol. Rep., 13, 101833 (2024); https://doi.org/10.1016/j.toxrep.2024.101833
  99. P.S.L. Paré, D.F.D.S. Hien, M. Youba, R.S. Yerbanga, A. Cohuet, L.-C. Gouagna, A. Diabaté, R. Ignell, R.K. Dabiré, O. Gnankiné and T. Lefèvre, Ecol. Evol., 14, e11187 (2024); https://doi.org/10.1002/ece3.11187
  100. A. Parveen, M.Q. Farooqi, W.W. Kyunn and M. Arshad, Pharmacogn. J., 9, 743 (2017); https://doi.org/10.5530/pj.2017.6.117
  101. N. Pournaghi, F. Khalighi-Sigaroodi, E. Safari and R. Hajiaghaee, Faslnamah-i Giyahan-i Daruyi, 19, 1 (2020); https://doi.org/10.29252/jmp.19.76.1
  102. T.P. Prohp, I.G. Ihimire, A.O. Madusha, H.O. Okpala, J.O. Erebor, C.A. Oyinbo, I.G. Ihimire A.O. Madusha H.O. Okpala J.O. Erebor C.A. Oyinbo, Pak. J. Nutr., 5, 114 (2006); https://doi.org/10.3923/pjn.2006.114.116
  103. T.P. Prohp, A.O. Madusha, I.O. Onoaghe, U. Inegbenebor, R.I. Okoli, I.G. Ihimire A.O. Madusha H.O. Okpala J.O. Erebor C.A. Oyinbo, Pak. J. Nutr., 5, 114 (2006); https://doi.org/10.3923/pjn.2006.114.116
  104. M.P. Chander, C.R. Pillai and P. Vijayachari, Bangladesh J. Pharmacol., 11, 126 (2016); https://doi.org/10.3329/bjp.v11i1.24055
  105. C.Y. Ragasa, J. Ganzon, J. Hofileña, B. Tamboong and J.A. Rideout, Chem. Pharm. Bull., 51, 1208 (2003); https://doi.org/10.1248/cpb.51.1208
  106. V.M. Rao, G.L.V. Damu, D. Sudhakar, V. Siddaiah and C.V. Rao, ARKIVOC, 2008, 285 (2008); https://doi.org/10.3998/ark.5550190.0009.b28
  107. V.H. Rathi, A.R. Jeice and K. Jayakumar, Appl. Surf. Sci. Adv., 18, 100476 (2023); https://doi.org/10.1016/j.apsadv.2023.100476
  108. S. Riyaz, M.D.S. Munawar and N.V. Rao, Indian J. Pharm. Sci., 83, 393 (2021); https://doi.org/10.36468/pharmaceutical-sciences.786
  109. M.G.F. Rodrigues, R.B. Mazzini, K.F.L. Pivetta, M.D.C. Alves and J.A. Desidério, Acta Sci. Agron., 34, 259 (2012); https://doi.org/10.4025/actasciagron.v34i3.13765
  110. V. Roumy, L. Ruiz, J.C. Ruiz-Macedo, A.-L. Gutierrez-Choquevilca, J. Samaillie, L.A. Encinas, W.R. Mesia, H.E. Ricopa Cotrina, C. Rivière, S. Sahpaz, S. Bordage, G. Garçon, J. Dubuisson, S. Anthérieu, K. Seron and T. Hennebelle, J. Ethnopharmacol., 255, 112735 (2020); https://doi.org/10.1016/j.jep.2020.112735
  111. V. Sharma and G. Rajani, Indian J. Pharmacol., 43, 168 (2011); https://doi.org/10.4103/0253-7613.77354
  112. S. Siddiqui, O. Erharuyi, A. Falodun, M.I. Choudhary and S. Yousuf, Acta Crystallogr. E Crystallogr. Commun., 71, o739 (2015); https://doi.org/10.1107/S2056989015016461
  113. W. Sirisarn, A. Mordmuang, Y. Sukpondma, S. Obchoei and S. Saeheng, Trends in Sciences, 22, 9368 (2025); https://doi.org/10.48048/tis.2025.9368
  114. S.L. Sousa, Í.M.D.S. Araújo, S.R.A. Medeiros and E.M.C.D. Silva, Rev. Caatinga, 34, 728 (2021); https://doi.org/10.1590/1983-21252021v34n325rc
  115. S.R. Suryawanshi, N.P. Thakare, D.P. More and N.A. Thombre, Drug Deliv., 22, 894 (2015); https://doi.org/10.3109/10717544.2013.860205
  116. A.E. Ubhenin, A.A. Adefolalu, K. Oriakhi, F.A. Adamude, E.J. Dingwoke, J.O. Ikebuiro, B.C. Chiwendu, M.L. Muhammad and K. Omage, Heliyon, 10, e23401 (2024); https://doi.org/10.1016/j.heliyon.2023.e23401
  117. A. Udayakumar and T.M. Shivalingaswamy, Sociobiology, 66, 61 (2019); https://doi.org/10.13102/sociobiology.v66i1.3558
  118. A. Udayakumar, H.S. Venu, A. Kandan, M. Arvind, S. Joshi and T.M. Shivalingaswamy, Curr. Sci., 127, 85 (2024); https://doi.org/10.18520/cs/v127/i1/85-90
  119. V. Senthil, S. Gopalakrishnan, R. Sureshkumar, N. Jawahar, G.N. Ganesh and D. Nagasamyvenkatesh, Asian J. Pharm., 4, 64 (2010); https://doi.org/10.4103/0973-8398.63979
  120. F. Verloove, Biodivers. Data J., 9, e62878 (2021); https://doi.org/10.3897/BDJ.9.e62878
  121. Y. Xu, B. Liang, C. Kong and Z. Sun, BioMed Res. Int., 2021, 9910365 (2021); https://doi.org/10.1155/2021/9910365
  122. L.T. Zalsabela, B. Elya and A. Noviani, J. Young Pharm., 10, s111 (2018); https://doi.org/10.5530/jyp.2018.2s.22
  123. Z. Zhang, P. Wang, M. Chen, L. Xie, X. Zhang, Y. Shi, W. Lu, Q. Zhang and C. Li, Int. J. Mol. Sci., 24, 4917 (2023); https://doi.org/10.3390/ijms24054917
  124. S. Scheler, A. Fahr and X. Liu, ADMET DMPK, 2, (2015); https://doi.org/10.5599/admet.2.4.147
  125. K.M. Chen, T.E. Spratt, B.A. Stanley, D.A. DeCotiis, M.C. Bewley, J.M. Flanagan, D.A. Desai, E.S. Das, E.S. Fiala, S. Amin and K. El-Bayoumy, Cancer Res., 67, 10475 (2007); https://doi.org/10.1158/0008-5472.CAN-07-2510
  126. F.M. Moreira, R.S.A. Nobrega, R.P. Santos, C.C. Silva and J.C.A. Nobrega, Rev. Arvore, 42, e420212 (2018); https://doi.org/10.1590/1806-90882018000200012
  127. S.S. Patel, N.K. Verma, C. Chatterjee and K. Gauthaman, Int. J. Appl. Res. Nat. Prod., 3, 1 (2010).
  128. D. Schneidman-Duhovny, O. Dror, Y. Inbar, R. Nussinov and H.J. Wolfson, Nucleic Acids Res., 36(suppl_2), W223 (2008); https://doi.org/10.1093/nar/gkn187
  129. J. Morimoto, K. Miyamoto, Y. Ichikawa, M. Uchiyama, M. Makishima, Y.M. Hashimoto and M. Ishikawa, Sci. Rep., 11, 12697 (2021); https://doi.org/10.1038/s41598-021-92028-y
  130. A. Tedjani, A.E. Chemsa, A. Mouane, N.A. Righi, M. Benyahkm, N. Hadri, Z. Boual, A.V. Atoki and M. Messaoudi, Nat. Prod. Commun., 20, 1934578X251337949 (2025); https://doi.org/10.1177/1934578X251337949
  131. R. Boonnop, P. Meetam, L. Siangjong, P. Tuchinda, P. Thongphasuk, S. Soodvilai and S. Soodvilai, Drug Metab. Pharmacokinet., 50, 100500 (2023); https://doi.org/10.1016/j.dmpk.2023.100500
  132. S. Sareen, L. Joseph and G. Mathew, Int. J. Pharm. Investig., 2, 12 (2012); https://doi.org/10.4103/2230-973X.96921
  133. M. Karthikeyan, S. Sabarathinam, H. Mohan and B. Usha, Tradit. Med. Res., 10, 65 (2025); https://doi.org/10.53388/TMR20241216001
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