Copyright (c) 2025 Dhanraj G, Swetha SP, Anahas Perianaika Matharasi Antonyraj
This work is licensed under a Creative Commons Attribution 4.0 International License.
Fabrication and Characterization of Fe-Mg/HAP-Loaded PCL/PEG Nanofibrous Membranes for Improved Wound Healing
Corresponding Author(s) : A. Anahas Perianaika Matharasi
Asian Journal of Chemistry,
Vol. 37 No. 8 (2025): Vol 37 Issue 8, 2025
Abstract
This study investigates the effect of incorporating Fe/Mg-hydroxyapatite (Fe/Mg-HAP) nanoparticles into electrospun polycaprolactone (PCL) membranes, with a focus on surface wettability, morphology, biocompatibility and hemocompatibility for potential biomedical applications. The incorporation of Fe/Mg-HAP nanoparticles significantly enhanced the surface hydrophilicity, as evidenced by a decrease in the contact angle from 76.3º (PCL) to 67.4º (PFe/Mg-HAP), suggesting improved interaction with aqueous environments. Scanning electron microscopy (SEM) and roughness measurements revealed that Fe/Mg-HAP incorporation led to the increased surface roughness, which is beneficial for protein adsorption and cell attachment. Biocompatibility studies demonstrated that the PFe/Mg-HAP membranes maintained high cell viability (~85%), supporting their potential for tissue engineering applications. Hemocompatibility evaluations showed the minimal hemolytic activity, moderate platelet adhesion and stable coagulation profiles, indicating a favourable interaction with blood components. These results highlight the promising potential of Fe/Mg-HAP-incorporated electrospun PCL membranes for use in blood-contacting medical devices, wound healing and tissue engineering. The study highlights the importance of nanofiller incorporation in enhancing the physico-chemical properties of electrospun membranes, providing the solution for their future application in regenerative medicines.
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S. Ni, Y. Yuan, Y. Kuang and X. Li, Front. Immunol., 13, 816282 (2022); https://doi.org/10.3389/fimmu.2022.816282
Q. Mu, L. Chen, X. Gao, S. Shen, W. Sheng, J. Min and F. Wang, Sci. Bull., 66, 1806 (2021); https://doi.org/10.1016/j.scib.2021.02.010
K. Ukaegbu, E. Allen and K.K. Svoboda, Int. Wound J., 22, e70330 (2025); https://doi.org/10.1111/iwj.70330
M. Ahmadi Bonakdar and D. Rodrigue, Macromol, 4, 58 (2024); https://doi.org/10.3390/macromol4010004
H.A.S. Al-Naymi, M.H. Al-Musawi, M. Mirhaj, H. Valizadeh, A.M.D. Pajooh, M. Shahriari-Khalaji, F. Sharifianjazi, K. Tavamaishvili, N. Kazemi, S. Salehi, A. Arefpour and M. Tavakoli, Heliyon, 10, e38497 (2024); https://doi.org/10.1016/j.heliyon.2024.e38497
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P. Liu, X. Liu, L. Yang, Y. Qian, Q. Lu, A. Shi, S. Wei, X. Zhang, Y. Lv and J. Xiang, Front. Bioeng. Biotechnol., 12, 1331078 (2024); https://doi.org/10.3389/fbioe.2024.1331078
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H. Wang, C. Chu, R. Cai, S. Jiang, L. Zhai, J. Lu, X. Li and S. Jiang, RSC Adv., 5, 53550 (2015); https://doi.org/10.1039/C5RA07806G
P. Palanisamy, W.F. Crossia, D. Prakash and A.P.M. Antonyraj, J. Orthop. Res., 100677 (2025); https://doi.org/10.1016/j.jorep.2025.100677
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