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Vol. 37 No. 7 (2025): Vol 37 Issue 7, 2025

Copyright (c) 2025 Quang Trung Nguyen, Phuong Nam Pham Thi, Hau Tan Van

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Copper(II) Complexes Bearing Unsymmetrical NNO-Tridentate Schiff Bases: Synthesis, Spectral Characterization, Electrochemical Behaviour and their Biological Activity

https://doi.org/10.14233/ajchem.2025.33892
Quang Trung Nguyen
Institute of Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Str., Cau Giay Dist., Hanoi, Vietnam
https://orcid.org/0000-0002-6882-4124
Phuong Nam Pham Thi
Institute of Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Str., Cau Giay Dist., Hanoi, Vietnam
Ngoc Tu Duong
Institute of Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Str., Cau Giay Dist., Hanoi, Vietnam
Hau Tan Van
Department of Chemical Technology, Ho Chi Minh City University of Industry and Trade, 140 Le Trong Tan Str., Tan Phu Dist., Ho Chi Minh City, Vietnam

Corresponding Author(s) : Quang Trung Nguyen

nqtrung@ich.vast.vn

Asian Journal of Chemistry, Vol. 37 No. 7 (2025): Vol 37 Issue 7, 2025

Abstract

In this work, three mono-condensation Schiff bases of o-phenyldiamine with 5-t-butylsalicylaldehyde (AIBP), 3,5-di-t-butylsalicylaldehyde (AIdBP) and 2-hydroxy-1-naphthaldehyde (AINA) were prepared and coordinated by CuCl2·2H2O without and with the presence of pyridine to form six tridentate Schiff base copper(II) complexes. The synthesized unsymmetrical Schiff base copper(II) complexes were characterized by diverse physico-chemical methods like mass, infrared, ultraviolet-visible spectroscopies and magnetic susceptibility measurements to indicate that the coordination of copper(II) with the synthetic Schiff bases at NNO atoms and the geometry around central ion is distorted square-planar or square-pyramidal probably. Then electrochemical properties of the obtained Schiff base copper(II) complexes were studied using cyclic voltammetry (CV). [Cu(II)(AINA)Cl] has exhibited that the peak current increases with the increase of the scan rates linearly. All the Schiff base copper(II) complexes have been screened for their in vitro antibacterial activity on Gram-positive bacteria, Staphylococcus aureus, Bacillus subtilis, Lactobacillus fermentum. [Cu(II)(AIdBP)Cl] has expressed the effective activity for all three tested bacteria. The in vitro cytotoxicity of the synthetic Schiff base copper(II) complexes for human cancer cell lines, MCF-7 and HepG-2, were examined as well.

Keywords

Tridentate Schiff bases Copper(II) complexes Electrochemical properties Antibacterial activity Cytotoxicity
(1)
Nguyen, Q. T.; Pham Thi, P. N.; Duong, N. T.; Van, H. T. Copper(II) Complexes Bearing Unsymmetrical NNO-Tridentate Schiff Bases: Synthesis, Spectral Characterization, Electrochemical Behaviour and Their Biological Activity. ajc 2025, 37, 1587-1593.
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