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Vol. 37 No. 7 (2025): Vol 37 Issue 7, 2025

Copyright (c) 2025 Bhagyashree Salunkhe, Ratnamala Bendre, sharda Gadale

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis, Characterization, in vitro Antimicrobial and Antiproliferative Potentials of Novel Carvacrol Based Schiff Base Derivatives

https://doi.org/10.14233/ajchem.2025.33838
Bhagyashree Salunkhe
Department of Chemistry, Yashwantrao Mohite College, Bharati Vidyapeeth (Deemed to be University), Pune-411038, India
https://orcid.org/0009-0002-2010-3990
Ratnamala Bendre
Department of Chemistry, Kavayitri Bahinabai Chaudhari North Maharashtra University, Jalgaon-425001, India
https://orcid.org/0000-0001-6987-9912
Sharda Gadale
Department of Chemistry, Yashwantrao Mohite College, Bharati Vidyapeeth (Deemed to be University), Pune-411038, India
https://orcid.org/0000-0002-2872-505X

Corresponding Author(s) : Sharda Gadale

dagade@rediffmail.com

Asian Journal of Chemistry, Vol. 37 No. 7 (2025): Vol 37 Issue 7, 2025

Abstract

A series of novel carvacrol based Schiff base derivatives (5-Cl, Nap, 3,5-Dibr, DEAS and 5-Br) were synthesized and characterized through FT-IR, 1H NMR and 13C NMR spectroscopic methods. The FT-IR confirmed the characteristic peak of imine (–CH=N–) at 1619-1514 cm-1, while the NMR spectra confirmed the arrangement of aromatic and aliphatic protons and carbons with halogen substitutions. The synthesized Schiff Base derivatives had significant biological activity, particularly Nap, 5-Br, and 3,5-Dibr, which exhibited high cytotoxicity against the A-549 lung cancer cell line. Antimicrobial assay indicated a strong lethality in brine shrimp assays and acceptable antibacterial activity, especially for 5-Cl and 3,5-Dibr, with minimum inhibitory concentrations (MIC). These findings confirm the structural integrity and pharmacological significance of Schiff bases, highlighting their usefulness in the development of anticancer and antibacterial drugs.

Keywords

Carvacrol Schiff base Azomethine Anticancer activity Brine shrimp lethality assay
(1)
Salunkhe, B.; Bendre, R.; Gadale, S. Synthesis, Characterization, in Vitro Antimicrobial and Antiproliferative Potentials of Novel Carvacrol Based Schiff Base Derivatives. ajc 2025, 37, 1570-1576.
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References
  1. W. Maczka, M. Twardawska, M. Grabarczyk and K. Winska, Antibiotics, 12, 824 (2023); https://doi.org/10.3390/antibiotics12050824 DOI: https://doi.org/10.3390/antibiotics12050824
  2. S. Maisanaba, M. Llana-Ruiz-Cabello, D. Gutiérrez-Praena, S. Pichardo, M. Puerto, A.I. Prieto, A. Jos and A.M. Cameán, Food Rev. Int., 33, 447 (2017); https://doi.org/10.1080/87559129.2016.1175010 DOI: https://doi.org/10.1080/87559129.2016.1175010
  3. N.B. Rathod, P. Kulawik, F. Ozogul, J.M. Regenstein and Y. Ozogul, Trends Food Sci. Technol., 116, 733 (2021); https://doi.org/10.1016/j.tifs.2021.08.023 DOI: https://doi.org/10.1016/j.tifs.2021.08.023
  4. C.J. Dias, H.A. Costa, C.A. Alves Dias-Filho, A.C. Ferreira, B. Rodrigues, M.C. Irigoyen, A.C. Romão Borges, V. de Andadre Martins, F.C. Branco Vidal, R.M. Ribeiro, N.S. Filho and C.T. Mostarda, Eur. J. Pharmacol., 917, 174717 (2022); https://doi.org/10.1016/j.ejphar.2021.174717 DOI: https://doi.org/10.1016/j.ejphar.2021.174717
  5. G. Bayramoglu, H. Senturk, A. Bayramoglu, M. Uyanoglu, S. Colak, A. Ozmen and D. Kolankaya, Cytotechnology, 66, 251 (2014); https://doi.org/10.1007/s10616-013-9563-5 DOI: https://doi.org/10.1007/s10616-013-9563-5
  6. G. Chinigò, A. Fiorio Pla and D. Gkika, Front. Pharmacol., 11, 581455 (2020); https://doi.org/10.3389/fphar.2020.581455 DOI: https://doi.org/10.3389/fphar.2020.581455
  7. U.B. More, H.P. Narkhede, D.S. Dalal and P.P. Mahulikar, Synth. Commun., 37, 1957 (2007); https://doi.org/10.1080/00397910701354608 DOI: https://doi.org/10.1080/00397910701354608
  8. J. Mastelic, I. Jerkovic, I. Blaževic, M. Poljak-Blaži, S. Borovic, I. Ivancic-Bace, V. Smreèki, N. Žarkovic, K. Brèic-Kostic, D. Vikic-Topic and N. Müller, J. Agric. Food Chem., 56, 3989 (2008); https://doi.org/10.1021/jf073272v DOI: https://doi.org/10.1021/jf073272v
  9. M.I. Konaklieva, SLAS Discov.: Adv. Sci. Drug Discov., 24, 419 (2018); https://doi.org/10.1177/2472555218812657 DOI: https://doi.org/10.1177/2472555218812657
  10. E. Raczuk, B. Dmochowska, J. Samaszko-Fiertek and J. Madaj, Molecules, 27, 787 (2022); 10.3390/molecules27030787 DOI: https://doi.org/10.3390/molecules27030787
  11. A. Soroceanu and A. Bargan, Crystals, 12, 1436 (2022); https://doi.org/10.3390/cryst12101436 DOI: https://doi.org/10.3390/cryst12101436
  12. Z. Zhang, Q. Song, Y. Jin, Y. Feng, J. Li and K. Zhang, Metals, 13, 386 (2023); https://doi.org/10.3390/met13020386 DOI: https://doi.org/10.3390/met13020386
  13. C. Boulechfar, H. Ferkous, A. Delimi, A. Djedouani, A. Kahlouche, A. Boublia, A.S. Darwish, T. Lemaoui, R. Verma and Y. Benguerba, Inorg. Chem. Commun., 150, 110451 (2023); https://doi.org/10.1016/j.inoche.2023.110451 DOI: https://doi.org/10.1016/j.inoche.2023.110451
  14. Nidhi, Siddharam, D.P. Rao, A.K. Gautam, A. Verma and Y. Gautam, Results Chem., 13, 101941 (2025); https://doi.org/10.1016/j.rechem.2024.101941 DOI: https://doi.org/10.1016/j.rechem.2024.101941
  15. I. Mushtaq, M. Ahmad, M. Saleem and A. Ahmed, Futur. J. Pharm. Sci., 10, 16 (2024); https://doi.org/10.1186/s43094-024-00594-5 DOI: https://doi.org/10.1186/s43094-024-00594-5
  16. S. Thakur, A. Jaryal and A. Bhalla, Results Chem., 7, 101350 (2024); https://doi.org/10.1016/j.rechem.2024.101350 DOI: https://doi.org/10.1016/j.rechem.2024.101350
  17. Beena, D. Kumar and D.S. Rawat, Bioorg. Med. Chem. Lett., 23, 641 (2013); https://doi.org/10.1016/j.bmcl.2012.12.001 DOI: https://doi.org/10.1016/j.bmcl.2012.12.001
  18. B.N. Meyer, N.R. Ferrigni, J.E. Putnam, L.B. Jacobsen, D.E. Nichols and J.L. McLaughlin, Planta Med., 45, 31 (1982); https://doi.org/10.1055/s-2007-971236 DOI: https://doi.org/10.1055/s-2007-971236
  19. F. Baquero, J. Antimicrob. Chemother., 39(Suppl. A), 1 (1997); https://doi.org/10.1093/jac/39.suppl_1.1 DOI: https://doi.org/10.1093/jac/39.suppl_1.1
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