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Vol. 37 No. 7 (2025): Vol 37 Issue 7, 2025

Copyright (c) 2025 Showkat Ahmad Bhawani, Aqil Faiz Mohamad Ramezan, Rachel Marcella Roland, Mohamad Aiman Othman, Aldrin Felix Simbas

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis of Molecularly Imprinted Polymers for the Extraction of p-Hydroxybenzoic Acid

https://doi.org/10.14233/ajchem.2025.33574
Showkat Ahmad Bhawani
Faculty of Resource Science and Technology, Universiti Malaysia Sarawak, Kota Samarahan, Sarawak-94300, Malaysia
https://orcid.org/0000-0001-5756-5457
Aqil Faiz Mohamad Ramezan
Faculty of Resource Science and Technology, Universiti Malaysia Sarawak, Kota Samarahan, Sarawak-94300, Malaysia
Rachel Marcella Roland
Faculty of Resource Science and Technology, Universiti Malaysia Sarawak, Kota Samarahan, Sarawak-94300, Malaysia
https://orcid.org/0009-0008-2284-1309
Mohamad Aiman Othman
Faculty of Resource Science and Technology, Universiti Malaysia Sarawak, Kota Samarahan, Sarawak-94300, Malaysia
Aldrin Felix Simbas
Faculty of Resource Science and Technology, Universiti Malaysia Sarawak, Kota Samarahan, Sarawak-94300, Malaysia

Corresponding Author(s) : Showkat Ahmad Bhawani

sabhawani@gmail.com

Asian Journal of Chemistry, Vol. 37 No. 7 (2025): Vol 37 Issue 7, 2025

Abstract

p-Hydroxybenzoic acid (p-HBA) is widely found in the environment due of its exceptional properties and has been used in the synthesis of variety of products such as preservatives, dyes, bactericides, etc. This causes a huge disposal of p-HBA in the environment which is considered to be harmful to both aquatic and terrestrial life. The molecular imprinting technique was employed to fabricate a molecularly imprinted polymer (MIP) that possesses selective binding sites for the p-HBA. In this study, p-HBA was used as the template molecule for the MIP synthesis, which was carried out using the precipitation polymerization method with a non-covalent approach. Acrylic acid was employed as the functional monomer, while ethylene glycol dimethylacrylate (EGDMA) was utilized as the cross-linker. The characterization of the MIP of p-HBA was conducted with scanning electron microscopy (SEM) and Fourier transform infrared (FTIR). The SEM results showed that both MIP and the non-imprinted polymer (NIP) of p-HBA were spherical in shape. The MIP attained its highest efficiency at optimum conditions of 1 ppm initial concentration, 0.4 g of polymer dosage and 210 min contact time. Moreover, the competitive binding assay indicated that the MIP displayed a greater affinity towards p-HBA than benzoic acid. The synthesized MIP was successfully used for the extraction p-HBA from blood serum and the extraction efficiency was about 80.56%.

Keywords

p-Hydroxybenzoic acid Molecularly imprinting polymer Blood serum
(1)
Bhawani, S. A.; Ramezan, A. F. M.; Roland, R. M.; Othman, M. A.; Simbas, A. F. Synthesis of Molecularly Imprinted Polymers for the Extraction of P-Hydroxybenzoic Acid. ajc 2025, 37, 1736-1742.
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