Copyright (c) 2025 Truyen D. Phung, Thanh Le, Anh T. P. Phung
This work is licensed under a Creative Commons Attribution 4.0 International License.
Synthesis and Structural Characterization of Hydroxy Butyl-β-cyclodextrin
Corresponding Author(s) : Thanh N.K. Le
Asian Journal of Chemistry,
Vol. 37 No. 6 (2025): Vol 37 Issue 6, 2025
Abstract
Hydroxy butyl-β-cyclodextrin was successfully synthesized in 1.5% NaOH solution to possess the highest yield of 75.350 ± 0.030% and degree of substitution of 5.230 ± 0.012 prior to structurally characterized. The study employed infrared radiation for main functional groups, 1H, 13C, distortionless enhancement by polarization transfer, correlation spectroscopy, heteronuclear single quantum coherence, heteronuclear multiple bond correlation nuclear magnetic resonance spectra in deuterium oxide solution and mass spectroscopy data to confirm the required structure of the hydroxy butyl-β-cyclodextrin derivatives with varying degrees of substitution.
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- S. Kalepu and V. Nekkanti, Acta Pharm. Sin. B, 5, 442 (2015); https://doi.org/10.1016/j.apsb.2015.07.003
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References
S. Kalepu and V. Nekkanti, Acta Pharm. Sin. B, 5, 442 (2015); https://doi.org/10.1016/j.apsb.2015.07.003
C. Tsunoda, K. Hasegawa, R. Hiroshige, T. Kasai, H. Yokoyama and S. Goto, Mol. Pharm., 20, 5032 (2023); https://doi.org/10.1021/acs.molpharmaceut.3c00291
H. Leemhuis, R.M. Kelly and L. Dijkhuizen, Appl. Microbiol. Biotechnol., 85, 823 (2010); https://doi.org/10.1007/s00253-009-2221-3
F. Bahavarnia, M. Hasanzadeh, P. Bahavarnia and N. Shadjou, RSC Adv., 14, 13384 (2024); https://doi.org/10.1039/D4RA01370K
B.G. Poulson, Q.A. Alsulami, A. Sharfalddin, E.F. El Agammy, F. Mouffouk, A.-H. Emwas, L. Jaremko and M. Jaremko, Polysaccharides, 3, 1 (2021); https://doi.org/10.3390/polysaccharides3010001
P. Li, J. Song, X. Ni, Q. Guo, H. Wen, Q. Zhou, Y. Shen, Y. Huang, P. Qiu, S. Lin and H. Hu, Int. J. Pharm., 513, 347 (2016); https://doi.org/10.1016/j.ijpharm.2016.09.036
G. Tiwari, R. Tiwari and A. Rai, J. Pharm. Bioallied Sci., 2, 72 (2010); https://doi.org/10.4103/0975-7406.67003
J.S. Kim, Y.J. Choi, M.R. Woo, S. Cheon, S.H. Ji, D. Im, F. ud Din, J.O. Kim, Y.S. Youn, K.T. Oh, S.-J. Lim, S.G. Jin and H.-G. Choi, Carbohydr. Polym., 271, 118433 (2021); https://doi.org/10.1016/j.carbpol.2021.118433
H.Y. Sun, Y. Bai, M.G. Zhao, A.Y. Hao, G.Y. Xu, J. Shen, J.Y. Li, T. Sun and H.C. Zhang, Carbohydr. Res., 344, 1999 (2009); https://doi.org/10.1016/j.carres.2009.07.010
M.S. Yeasmin and M.I.H. Mondal, Int. J. Biol. Macromol., 80, 725 (2015); https://doi.org/10.1016/j.ijbiomac.2015.07.040
D.T. Phung, T.V. Dang and H.V. Huynh, Vietnam J. Online, 23, 1 (2014).
M. Malanga, M. Bálint, I. Puskás, K. Tuza, T. Sohajda, L. Jicsinszky, L. Szente and É. Fenyvesi, Beilstein J. Org. Chem., 10, 3007 (2014); https://doi.org/10.3762/bjoc.10.319
J. Pitha, J. Milecki, H. Fales, L. Pannell and K. Uekama, Int. J. Pharm., 29, 73 (1986); https://doi.org/10.1016/0378-5173(86)90201-2
G.B.B. Njock, D.E. Pegnyemb, T.A. Bartholomeusz, P. Christen, B. Vitorge, J.-M. Nuzillard, R. Shivapurkar, M. Foroozandeh and D. Jeannerat, Chimia, 64, 235 (2010); https://doi.org/10.2533/chimia.2010.235
X. Ma, Molecules, 27, 6466 (2022); https://doi.org/10.3390/molecules27196466
X.-L. Liu, C.-F. Zhu, H.-C. Liu and J.-M. Zhu, Des. Monomers Polym., 25, 75 (2022); https://doi.org/10.1080/15685551.2022.2054118
R.I. Baron, G. Biliuta, A.-M. Macsim, M.V. Dinu and S. Coseri, Polymers, 15, 3930 (2023); https://doi.org/10.3390/polym15193930
K. Shi, X. Tao, F. Hong, H. He, Y. Ji and J. Li, J. Coal Sci. Eng. China, 18, 396 (2012); https://doi.org/10.1007/s12404-012-0411-6
T. Yamagaki and Y. Makino, Mass Spectrom., 6, S0073 (2017); https://doi.org/10.5702/massspectrometry.S0073
M. Grabarics, M. Lettow, C. Kirschbaum, K. Greis, C. Manz and K. Pagel, Chem. Rev., 122, 7840 (2022); https://doi.org/10.1021/acs.chemrev.1c00380
J. Biernacka, K. Betlejewska-Kielak, J. Witowska-Jarosz, E. Klosiñska-Szmurlo and A.P. Mazurek, J. Incl. Phenom. Macrocycl. Chem., 78, 437 (2014); https://doi.org/10.1007/s10847-013-0315-0
