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Vol. 37 No. 6 (2025): Vol 37 Issue 6, 2025

Copyright (c) 2025 Deepak Thippesh, Krishnakumar Velayudhannair

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Exploring the Pharmaceutical Potential of Meretrix casta (Gmelin, 1791) (Mollusca: Bivalvia)

https://doi.org/10.14233/ajchem.2025.33827
Deepak Thippesh
Department of Life Sciences, Christ University, Hosur Road, Dharmaram College Post, Bengaluru-560029, India
https://orcid.org/0000-0001-6313-774X
Krishnakumar Velayudhannair
Department of Life Sciences, Christ University, Hosur Road, Dharmaram College Post, Bengaluru-560029, India
https://orcid.org/0000-0002-2183-4632

Corresponding Author(s) : Krishnakumar Velayudhannair

krishnakumar.v@christuniversity.in

Asian Journal of Chemistry, Vol. 37 No. 6 (2025): Vol 37 Issue 6, 2025

Abstract

Meretrix casta, a marine mollusk, has been recognized traditionally for its nutritional and medicinal properties. This study aims to investigate the pharmacological potential of M. casta extracts, specifically focusing on the antioxidant, hemolytic, anti-inflammatory and antimicrobial activities. The antioxidant activity, assessed via hydrogen peroxide scavenging and phosphomolybdate assays, revealed concentration-dependent inhibition, with the methanol extract showing 61.04% inhibition at 100 µg/mL compared to 61.19% for ethyl acetate, while the standard ascorbic acid exhibited 87.80%. Anti-inflammatory activity was evaluated using heat-induced hemolysis, hypotonicity-induced hemolysis and protein denaturation assays. Both extracts demonstrated significant anti-inflammatory effects, with the ethyl acetate extract achieving 85.40% inhibition of hemolysis, closely matching acetylsalicylic acid’s 90.50% and methanol extract showing 87.60% at 100 µg/mL. Antibacterial and antifungal assays demonstrated significant inhibitory effects against pathogenic bacteria and fungi, with the methanolic extract frequently exhibiting higher efficacy. These findings highlight the therapeutic potential of M. casta extracts as natural bioactive agents. Future investigations should aim to isolate and characterize the specific bioactive compounds underlying these pharmacological effects and to explore their mechanisms of action in detail. Such studies could pave the way for new therapies derived from marine biodiversity, addressing various health challenges.

Keywords

Meretrix casta Natural antioxidants Medicinal marine mollusks Therapeutic marine resources
(1)
Thippesh, D.; Velayudhannair, K. Exploring the Pharmaceutical Potential of Meretrix Casta (Gmelin, 1791) (Mollusca: Bivalvia). ajc 2025, 37, 1469-1476.
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References
  1. B.M. Khan and Y. Liu, Compr. Rev. Food Sci. Food Saf., 18, 548 (2019); https://doi.org/10.1111/1541-4337.12429
  2. K. Chakraborty and M. Joy, Food Res. Int., 137, 109637 (2020); https://doi.org/10.1016/j.foodres.2020.109637
  3. R.A. Joshi and R. Nazeer, Amino Acids, 52, 1391 (2020); https://doi.org/10.1007/s00726-020-02899-0
  4. M. Liu, J. Wei, H. Wang, L. Ding, Y. Zhang and X. Lin, Chin. J. Oceanol. Limnol., 30, 724 (2012); https://doi.org/10.1007/s00343-012-1241-5
  5. A. Muscolo, O. Mariateresa, T. Giulio and R. Mariateresa, Int. J. Mol. Sci., 26, 3264 (2024); https://doi.org/10.3390/ijms25063264
  6. J. Lemire, A. Alhasawi, V.P. Appanna, S. Tharmalingam and V.D. Appanna, J. Appl. Microbiol., 123, 798 (2017); https://doi.org/10.1111/jam.13509
  7. E. Pranzini, G. Raugei and M.L. Taddei, Cancers, 14, 547 (2022); https://doi.org/10.3390/cancers14030547
  8. D.W. Green, J.-M. Lee and H.-S. Jung, Tissue Eng. Part B Rev., 21, 438 (2015); https://doi.org/10.1089/ten.teb.2015.0055
  9. N.G. Gomes, R. Dasari, S. Chandra, R. Kiss and A. Kornienko, Mar. Drugs, 14, 98 (2016); https://doi.org/10.3390/md14050098
  10. J.D. Santos, I. Vitorino, F. Reyes, F. Vicente and O.M. Lage, Antibiotics, 9, 455 (2020); https://doi.org/10.3390/antibiotics9080455
  11. P.K. Mukherjee, S. Banerjee and A. Kar, Natural Med., 517, 517 (2019); https://doi.org/10.1201/9781315187853-28
  12. W. Mbinda and C. Musangi, J. Phytopharmacol., 8, 161 (2019); https://doi.org/10.31254/phyto.2019.8403
  13. T. Odeleye, W.L. White and J. Lu, Food Funct., 10, 2278 (2019); https://doi.org/10.1039/C9FO00172G
  14. B.M. Ali, M. Boothapandi and A.S.S. Nasar, Data Brief, 28, 104972 (2020); https://doi.org/10.1016/j.dib.2019.104972
  15. S. Tabassum, S. Ahmad, K.R. Khan, F. Tabassum, A. Khursheed, Q. Zaman, N. Bukhari, A. Alfagham, A. Hatamleh and Y. Chen, Molecules, 27, 2377 (2022); https://doi.org/10.3390/molecules27082377
  16. S. Yesmin, A. Paul, T. Naz, A.A. Rahman, S.F. Akhter, M.I. Wahed, T.B. Emran and S.A. Siddiqui, Clin. Phytosci., 6, 59 (2020); https://doi.org/10.1186/s40816-020-00207-7
  17. J.E. Paduhilao and L.G. Yap-Dejeto, Acta Med. Philipp., 56, 3 (2021); https://doi.org/10.47895/amp.vi0.3136
  18. A. Georgieva, E. Tsvetanova, N. Chipev and A. Alexandrova, BioRisk, 17, 169 (2022); https://doi.org/10.3897/biorisk.17.77384
  19. M. Dhanalakshmi, Int. J. Pure Appl. Biosci, 4, 287 (2016); https://doi.org/10.18782/2320-7051.1789
  20. R.A. Nazeer and S.Y. Naqash, Med. J. Nutrition Metab., 6, 17 (2013); https://doi.org/10.3233/s12349-011-0088-1
  21. S. Krishnan, K. Chakraborty and P. Vijayagopal, Indian J. Fish., 66, 56 (2019); https://doi.org/10.21077/ijf.2019.66.1.80079-08
  22. B. Kumari and H. Solanki, Int. J. Plant Environ., 7, 169 (2021); https://doi.org/10.18811/ijpen.v7i02.08
  23. M. Ramamoorthy, G. Sankar and S.N. Jeyapriya, Sci. Acad., 4, 15 (2023).
  24. S. Woo, V. Denis, H. Won, K. Shin, G. Lee, T. Lee and S. Yum, Zool. Stud., 52, 15 (2013); https://doi.org/10.1186/1810-522X-52-15
  25. S.R. Susana and L.A. Salvador-Reyes, Antioxidants, 11, 607 (2022); https://doi.org/10.3390/antiox11040607
  26. E. Fernandes, T.G. Fonseca, T. Carriço, N. Mestre, Á. Tavares and M.J. Bebianno, Chemosphere, 261, 127678 (2020); https://doi.org/10.1016/j.chemosphere.2020.127678
  27. R.T. Shenai-Tirodkar, T. Pawar and T.G. Jagtap, Prog. Nutr., 14, 177 (2012).
  28. E. Ancheeva, M. El-Neketi, W. Song, W. Lin, G. Daletos, W. Ebrahim and P. Proksch, Curr. Org. Chem., 21, 426 (2017); https://doi.org/10.2174/1385272820666161017164957
  29. I. Manolakis and U. Azhar, Coatings, 10, 653 (2020); https://doi.org/10.3390/coatings10070653
  30. M. Abraúl, A. Alves, S. Hilário, T. Melo, T. Conde, M.R. Domingues and F. Rey, Mar. Drugs, 21, 199 (2023); https://doi.org/10.3390/md21040199
  31. M. Riera-Romo, L. Wilson-Savón and I. Hernandez-Balmaseda, J. Pharm. Pharmacogn. Res., 8, 368 (2020); https://doi.org/10.56499/jppres19.739_8.5.368
  32. M.F. De Guzman and F.A.T. Argente, Matrix Sci. Pharm., 6, 68 (2022); https://doi.org/10.4103/mtsp.mtsp_9_22
  33. M. Ramasamy and U. Balasubramanian, Int. J. Sci. Nat., 5, 109 (2014).
  34. R. Trifani, Noverita, T.A. Hadi and E. Sinaga, IOP Conf. Ser. Earth Environ. Sci., 948, 012069 (2021); https://doi.org/10.1088/1755-1315/948/1/012069
  35. B.-N. Han, L.-L. Hong, B.-B. Gu, Y.-T. Sun, J. Wang and J.-T. Liu, in eds.: Z. Li, Natural Products from Sponges, In: Symbiotic Microbiomes of Coral Reefs, Sponges, and Corals, Springer, Dordrecht, pp. 329-463 (2019).
  36. M.S. Kumar, J. Mycol. Med., 32, 101305 (2022); https://doi.org/10.1016/j.mycmed.2022.101305
  37. E.B.G. Jones, Bot. Mar., 66, 453 (2023); https://doi.org/10.1515/bot-2023-0017
  38. J. He, C. Shen, H. Liang, X. Fang and J. Lu, Fish Shellfish Immunol., 105, 330 (2020); https://doi.org/10.1016/j.fsi.2020.07.017
  39. S. Ponpandian, in eds.: M.I.D.M. Joyce and P. Manuelraj, Isolation, Structure Elucidation and Biological Activity of Marine Natural Products; In: Marine Nutraceuticals: Challenges and Opportunities, Research Culture Society and Publication, India, pp. 59-65 (2019).
  40. N.L. Thakur and A. Singh, in eds.: In: R. Pallela and H. Ehrlich, Chemical Ecology of Marine Sponges; In: Marine Sponges: Chemicobiological and Biomedical Applications, Springer, New Delhi, pp. 37-52 (2016).
  41. M.Y. Putra, T.A. Hadi and T. Murniasih, Asian Pac. J. Trop. Dis., 6, 732 (2016); https://doi.org/10.1016/S2222-1808(16)61119-2
  42. P. Bernabe, L. Becherán, G. Cabrera-Barjas, A. Nesic, C. Alburquenque, C.V. Tapia, E. Taboada, J. Alderete and P. De Los Ríos, Int. J. Biol. Macromol., 149, 962 (2020); https://doi.org/10.1016/j.ijbiomac.2020.01.126
  43. D. Thippesh and K. Velayudhannair, Integr. Sci. Technol., 12, 835 (2024); https://doi.org/10.62110/sciencein.jist.2024.v12.835
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