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Vol. 37 No. 6 (2025): Vol 37 Issue 6, 2025

Copyright (c) 2025 dr_poonam kaswan

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Synthesis and Antimicrobial Activity of Novel Sulfonyl Piperidine Carboxamide Derivatives Prepared from N-Boc-Piperidine-3-carboxylic Acid via Amide Coupling

https://doi.org/10.14233/ajchem.2025.33717
Shital Jagtap
Department of Chemistry, Annasaheb Magar College, Hadapsar, Pune-411028, India
Poonam Kaswan
Department of Industrial Chemistry, AISSMS Institute of Information Technology, Pune-411001, India
https://orcid.org/0000-0001-5138-7194

Corresponding Author(s) : Poonam Kaswan

poonamcym@gmail.com

Asian Journal of Chemistry, Vol. 37 No. 6 (2025): Vol 37 Issue 6, 2025

Abstract

Piperidines serve as pivotal synthetic building blocks in the realm of drug design, with their derivatives forming essential parts of a wide range of drugs and alkaloids. This study presents a novel approach involving sulfonyl derivatives of piperidine-3-carboxylic acid, achieved through amide coupling with substituted sulphonyl chlorides. The synthesized compounds underwent characterization via IR, 1H NMR, 13C NMR and MS analyses. Specifically, a series of novel sulphonamides derived from 1-(tert-butoxycarbonyl)piperidine-3-carboxylic acid was synthesized, given the significance of sulphonamides as a vital drug class. Antimicrobial activity screening against both Gram-positive and Gram-negative bacteria, as well as fungi, was evaluated. The MIC concentration results revealed moderate to good activity against Gram-positive and Gram-negative microorganisms and fungal organisms.

Keywords

Heterocycles Piperidine Amide Sulphonyl chlorides
(1)
Jagtap, S.; Kaswan, P. Synthesis and Antimicrobial Activity of Novel Sulfonyl Piperidine Carboxamide Derivatives Prepared from N-Boc-Piperidine-3-Carboxylic Acid via Amide Coupling. ajc 2025, 37, 1315-1321.
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