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Vol. 37 No. 5 (2025): Vol 37 Issue 5, 2025

Copyright (c) 2025 JITENDRA PATEL, Gatadi

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Innovative Non-Pharmacological Therapies for SARS-CoV-2 Infections: Advances, Challenges and Future Directions

https://doi.org/10.14233/ajchem.2025.33477
Gatadi Srikanth
GITAM School of Pharmacy, GITAM (Deemed to be University), Hyderabad-502329, India
https://orcid.org/0009-0005-4962-5030
Santoshachandra Rao Karanam
Department of Computer Science and Engineering, GITAM School of Technology, GITAM (Deemed to be University), Hyderabad-502329, India
https://orcid.org/0000-0002-5002-6677
Bhabani Sankar Satapathy
GITAM School of Pharmacy, GITAM (Deemed to be University), Hyderabad-502329, India
https://orcid.org/0000-0002-9175-8356
Parul Thapar
Department of Microbiology, Parul Institute of Applied Sciences, Parul University, Vadodara, India
https://orcid.org/0000-0003-1571-4789
Durga Prasad Beda
GITAM School of Pharmacy, GITAM (Deemed to be University), Hyderabad-502329, India
https://orcid.org/0000-0002-8135-3291
Jitendra Patel
Department of Pharmacognosy, Datta Meghe College of Pharmacy, Datta Meghe Institute of Higher Education (Deemed to be University), Sawangi (Meghe), Wardha-442001, India
https://orcid.org/0000-0001-8193-2878

Corresponding Author(s) : Jitendra Patel

jitendra.pharmacy@dmiher.edu.in

Asian Journal of Chemistry, Vol. 37 No. 5 (2025): Vol 37 Issue 5, 2025

Abstract

The COVID-19 pandemic has necessitated diverse therapeutic approaches, including drug-free therapies to complement pharmaceutical interventions. This review examines the current landscape, challenges and future perspectives of non-drug therapies for COVID-19. Critical approaches include oxygen therapy, mechanical ventilation, prone positioning, physical therapy, nutritional support, psychological support, hydration management and alternative therapies such as acupuncture and phototherapy. Despite their potential, these therapies face significant challenges, including disease variability, resource limitations, patient-specific factors, infection control issues and the need for robust clinical evidence. Future perspectives highlight the technological advancements such as telehealth, wearable devices and artificial intelligence; improved respiratory support systems; integrated multidisciplinary care; extensive public health initiatives; stringent clinical trials; personalized medicine; global health equity; mental health integration; lifestyle modifications and preparedness for future pandemics. Addressing these challenges and leveraging advancements will enhance the effectiveness and accessibility of drug-free therapies, improving patient outcomes and bolstering healthcare resilience against future pandemics.

Keywords

COVID-19 Drug-free remedies Nutritional support Clinical trials Integrated care
(1)
Srikanth, G.; Karanam, S. R.; Satapathy, B. S.; Thapar, P.; Beda, D. P.; Patel, J. Innovative Non-Pharmacological Therapies for SARS-CoV-2 Infections: Advances, Challenges and Future Directions. ajc 2025, 37, 1006-1016.
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