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Vol. 37 No. 5 (2025): Vol 37 Issue 5, 2025

Copyright (c) 2025 Quang Trung Nguyen, Phuong Nam Pham Thi

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Zinc(II) Complexes Containing Aromatic Hydrazones: Synthesis, Spectral Characterization, Luminescent Properties and a-Glucosidase Inhibition

https://doi.org/10.14233/ajchem.2025.33652
Quang Trung Nguyen
Institute of Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Str., Cau Giay Dist., Hanoi, Vietnam
https://orcid.org/0000-0002-6882-4124
Phuong Nam Pham Thi
Institute of Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Str., Cau Giay Dist., Hanoi, Vietnam

Corresponding Author(s) : Quang Trung Nguyen

nqtrung@ich.vast.vn

Asian Journal of Chemistry, Vol. 37 No. 5 (2025): Vol 37 Issue 5, 2025

Abstract

Four zinc(II) complexes were synthesized by the coordinating Zn2+ ions with novel aromatic hydrazone ligands. Based on the spectral analyses, the molecular ratio of Zn(II) ions to hydrazone ligands was established as 1:2, and a tetrahedral geometry around the zinc metal center was proposed for the synthesized aromatic hydrazone zinc(II) complexes. The aromatic hydrazone ligands probably coordinated with the metal Zn2+ via the carbonyl oxygen and deprotonated oxygen of salicyl ring. The fluorescence spectra of the synthesized zinc(II) complexes were analyzed in dichloromethane, revealing that the aromatic hydrazone ligands with various substituents generated a blue shift in the maximum emissions of the corresponding zinc(II) complexes. The inhibition of α-glucosidase by the synthesized hydrazone compounds was evaluated, and based on the antidiabetic activity results, the synthesized zinc(II) complexes demonstrate superior efficacy compared to the corresponding aromatic hydrazone ligands.

Keywords

Aromatic hydrazones Zinc(II) complexes Spectral characterization Luminescent properties α-Glucosidase inhibition
(1)
Nguyen, Q. T.; Pham Thi, P. N. Zinc(II) Complexes Containing Aromatic Hydrazones: Synthesis, Spectral Characterization, Luminescent Properties and a-Glucosidase Inhibition. ajc 2025, 37, 1191-1196.
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