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Vol. 37 No. 5 (2025): Vol 37 Issue 5, 2025

Copyright (c) 2025 Nomita Devi Sanjram, Lokendrajit Nahakpam, Sanatombi Devi Khongbantabam, Warjeet Singh Laitonjam, Keisham Surjit Singh, S. Suresh Kumar Singh

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Room Temperature C-C Coupling Reactions: Ullmann Reaction Catalyzed by Novel Biocatalytic System of Trapa natans L./Copper Acetate and its Antidiabetic Activity

https://doi.org/10.14233/ajchem.2025.33595
N.D. Sanjram
Department of Chemistry, Manipur University, Canchipur, Imphal-795003, India
https://orcid.org/0000-0002-7900-5255
L. Nahakpam
Department of Chemistry, Manipur University, Canchipur, Imphal-795003, India
S.D. Khongbantabam
Department of Chemistry, Manipur University, Canchipur, Imphal-795003, India
https://orcid.org/0009-0002-8592-5418
W.S. Laitonjam
Department of Chemistry, Manipur University, Canchipur, Imphal-795003, India
K.S. Singh
Department of Chemistry, Manipur University, Canchipur, Imphal-795003, India
https://orcid.org/0000-0002-9744-2360
S.S.K. Singh
Department of Botany, Manipur University, Canchipur, Imphal-795003, India
https://orcid.org/0000-0002-8491-7187

Corresponding Author(s) : N.D. Sanjram

nomi.ngel@gmail.com

Asian Journal of Chemistry, Vol. 37 No. 5 (2025): Vol 37 Issue 5, 2025

Abstract

The fibrous root system of Trapa natans L. (Hei-kak-yeli) provides a great surface area for adsorption of metals. By taking advantage of phytoremediation ability of T. natans L., the biocatalyst was prepared by using T. natans L. with copper acetate. The prepared biocatalyst was employed for the greener approach in coupling reaction of derivatives of aryl chloride and aryl bromide (a classic Ullmann reaction). The synthesis of biaryl derivatives using biocatalyst undergoes at room temperature in the presence of DMF as solvent and KOH as base for 15-20 h with 76-92% overall yields. The optimum amount of biocatalyst used is about 20-40 mg (0.128-0.256 mmol of Cu) for complete conversion, thereby representing the lowest amount of catalyst used for a general catalytic Ullmann reaction. Moreover, given that copper complexes exhibit significant potential for antidiabetic properties, a copper-based biocatalyst was synthesized, and its antidiabetic activity was assessed. Promising result of antidiabetic property was obtained and the IC50 value was found to be 5.74809 ± 0.5185 µg/mL.

Keywords

Antidiabetic Ullmann coupling Trapa natans L. Hei-kak-yeli Biocatalyst Biaryl derivative
(1)
Sanjram, N.; Nahakpam, L.; Khongbantabam, S.; Laitonjam, W.; Singh, K.; Singh, S. Room Temperature C-C Coupling Reactions: Ullmann Reaction Catalyzed by Novel Biocatalytic System of Trapa Natans L. Copper Acetate and Its Antidiabetic Activity. ajc 2025, 37, 1151-1158.
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