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Vol. 37 No. 4 (2025): Vol 37 Issue 4, 2025

Copyright (c) 2025 Nilesh Sakhare

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An Efficient Synthesis of Quinoline Derivatives using Polymer-Supported Sulphonic Acid via Friendlier Pathway: A Green Protocol

https://doi.org/10.14233/ajchem.2025.33390
N.D. Sakhare
Department of Chemistry and Research Centre, New Arts, Commerce and Science College (Autonomous), Ahmednagar-414001, India; Department of Chemistry, Late Kisandas Gulabchand Kataria College, Daund-413801, India
https://orcid.org/0009-0001-0713-156X
S.J. Takate
Department of Chemistry and Research Centre, New Arts, Commerce and Science College (Autonomous), Ahmednagar-414001, India
https://orcid.org/0000-0002-0025-5244
J.R. Deshmukh
Department of Chemistry, Late Kisandas Gulabchand Kataria College, Daund-413801, India
https://orcid.org/0009-0002-9311-5538
D.P. Waghmode
Department of Chemistry, Late Kisandas Gulabchand Kataria College, Daund-413801, India
https://orcid.org/0009-0007-4333-5264
S.D. Mhaske
Department of Chemistry and Research Centre, New Arts, Commerce and Science College (Autonomous), Ahmednagar-414001, India; Department of Chemistry, Dadapatil Rajale Arts, Commerce and Science College, Adinathnagar, Tal. Pathardi-414505, India
https://orcid.org/0000-0003-2494-9790

Corresponding Author(s) : S.D. Mhaske

sadhanamhaske@dprcollege.edu.in

Asian Journal of Chemistry, Vol. 37 No. 4 (2025): Vol 37 Issue 4, 2025

Abstract

An efficient method for synthesizing quinoline derivatives (3a-l) was reported using polyethylene glycol-based sulphonic acid (PEG-SA) and polystyrene-supported polyethylene glycol-based sulphonic acid (PS-PEG-SA) as recyclable catalysts via a friendlier reaction pathway. This strategy is more environmentally sustainable than traditional methods for synthesizing quinoline derivatives, yielding favorable yields and facilitating ease of operation under mild reaction conditions. In presence of PEG-SA/PS-PEG-SA catalyst, carbonyl compounds with an active α-methylene group were added to 2-aminophenyl ketones/aldehydes to produce substituted quinoline compounds. Adhering to green chemistry principles, this strategy provides a productive way to synthesize functionally useful quinoline derivatives, raising the hope for the breakthrough in the pharmaceutical and material sciences.

Keywords

PEG Polystyrene Sulphonic acid Quinolines Multicomponent reactions
(1)
Sakhare, N.; Takate, S.; Deshmukh, J.; Waghmode, D.; Mhaske, S. An Efficient Synthesis of Quinoline Derivatives Using Polymer-Supported Sulphonic Acid via Friendlier Pathway: A Green Protocol. ajc 2025, 37, 789-794.
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