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Vol. 37 No. 4 (2025): Vol 37 Issue 4, 2025

Copyright (c) 2025 Krishna Khartmol

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Synthesis, Spectroscopic Characterization and Biological Studies of Some Metal(II) Complexes of Nicotinic Hydrazide Moiety

https://doi.org/10.14233/ajchem.2025.33437
Krishna Mahadev
Department of PG Studies and Research in Chemistry, Gulbarga University, Kalaburagi-585106, India
https://orcid.org/0009-0004-2730-5389
Siddappa Kuruba
Department of PG Studies and Research in Chemistry, Gulbarga University, Kalaburagi-585106, India
https://orcid.org/0000-0002-6593-8046

Corresponding Author(s) : Siddappa Kuruba

siddappak1965@gmail.com

Asian Journal of Chemistry, Vol. 37 No. 4 (2025): Vol 37 Issue 4, 2025

Abstract

In this study, a new ligand N′-(1-(2-oxo-2H-chromen-3-yl)ethylidene)nicotinohydrazide was synthesized and characterized. Then, the ligand was reacted with Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) metal ions affording its metal(II) complexes. Through elemental analysis, molar conductance, magnetic data, UV-visible, FT-IR, 1H NMR and mass spectra, the structural characterization of all the metal(II) complexes were accomplished. The FT-IR data demonstrated that in the metal(II) complexes, the ligand chelated to metal ion in a tridentate manner. The UV-visible spectral and magnetic data showed that the complexes exhibit octahedral geometry. Additionally, ligand molecular docking studies were conducted. The antimicrobial study demonstrated that complex formation increased the free ligand activity. The Cd(II) complex is an efficient antifungal agent, whereas the Zn(II) and Cd(II) complexes may be regarded as promising antibacterial agents. Moreover, Cd(II) complex also demonstrated strong anti-TB properties against M. tuberculosis. The antioxidant activity results showed that the except Cd(II) complex, other metal(II) complexes were found to be more active than the parent ligand.

Keywords

Nicotinic hydrazide Antimicrobial activity Antioxidant activity Transition metal(II) complexes
(1)
Mahadev, K.; Kuruba, S. Synthesis, Spectroscopic Characterization and Biological Studies of Some Metal(II) Complexes of Nicotinic Hydrazide Moiety. ajc 2025, 37, 843-850.
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