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Vol. 37 No. 12 (2025): Vol 37 Issue 12, 2025

Copyright (c) 2025 N.K. Fuloria, L. Thangavelu, P. Kishore, S. Faridha, N. Sundaresan, T. Bhuvaneshwari, K. Arthi, S. Fuloria

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis, Characterization, Molecular Docking, Cell Viability and Biological Activity of New Cresol Analogues against Monilial Vulvovaginitis Triggering Pathogen

https://doi.org/10.14233/ajchem.2025.34713
N.K. Fuloria
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, AIMST University, Bedong 08100, Kedah, Malaysia
https://orcid.org/0000-0002-8970-5212
L. Thangavelu
Center for Global Health Research, Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai-600077, India
https://orcid.org/0000-0001-5662-1410
P. Kishore
Department of Microbiology, Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai-600077, India
https://orcid.org/0009-0009-5399-7784
S. Faridha
Department of Microbiology, Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai-600077, India
https://orcid.org/0009-0003-3075-6562
N. Sundaresan
Department of Biochemistry, Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai-600077, India
https://orcid.org/0009-0001-1347-944X
T. Bhuvaneshwari
Department of Biochemistry, Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai-600077, India
https://orcid.org/0009-0008-6428-3341
K. Arthi
Department of Biochemistry, Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai-600077, India
https://orcid.org/0009-0002-6714-1628
S. Fuloria
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, AIMST University, Bedong 08100, Kedah, Malaysia
https://orcid.org/0000-0002-5381-5655

Corresponding Author(s) : S. Fuloria

shivkanya_fuloria@aimst.edu.my

Asian Journal of Chemistry, Vol. 37 No. 12 (2025): Vol 37 Issue 12, 2025

Abstract

High biological potential of existing cresols and azomethine scaffolds considers them as promising leads for antimicrobial therapy, however the development of resistance and side effects limits their application in treatment of monilial vulvovaginitis. In present study, new cresols derivatives (NCDs) were designed, synthesized and characterized using ATR-IR, 1H/13C NMR and direct-mass spectrometry. All the synthesized were initially screened through molecular docking against C. albicans CYP51 (PDB ID: 5TZ1) and S. aureus DNA Gyrase B protein (PDB ID: 4URM). Study involved molecular docking of NCDs against 5TZ1 and 4URM proteins of C. albicans and S. aureus respectively, followed by synthesis of NCDs via imination and Schiff reaction of hydrazide analogue of cresol, in-vitro antibacterial and antifungal activity using disk diffusion method and cytotoxicity evaluation towards HEK-293 cells with the MTT assay. Novel NCDs exhibited high docking score against 5TZ1 and 4URM, high in vitro antibacterial and antifungal activity against C. albicans and S. aureus, and minimal cytotoxicity at 7.81 µg/mL. Overall, the study presents chemically validated and biologically promising NBA candidates for future development as peri-implantitis inhibitors. Based on the experimental results, this study concludes successful synthesis of NCDs as antibacterial and antifungal activity with negligible toxicity. This research also proposed that, these NCDs in future needs further evaluation for preclinical and clinical significance in monilial vulvovaginitis treatment.

Keywords

Synthesis Azomethines Cresol S. aureus C. albicans Docking studies Monilial vulvovaginitis
(1)
Fuloria, N.; Thangavelu, L.; Kishore, P.; Faridha, S.; Sundaresan, N.; Bhuvaneshwari, T.; Arthi, K.; Fuloria, S. Synthesis, Characterization, Molecular Docking, Cell Viability and Biological Activity of New Cresol Analogues Against Monilial Vulvovaginitis Triggering Pathogen. ajc 2025, 37, 3229-3235.
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References
  1. T.C. Felix, L.B. Araújo, D.V. Röder and R.D. Pedroso, Int. J. Women's Health, 2020, 49 (2020); https://doi.org/10.2147/IJWH.S229366 DOI: https://doi.org/10.2147/IJWH.S229366
  2. H. Brown and M. Drexler, Popul. Health Manag., 23S1, S-3 (2020); https://doi.org/10.1089/pop.2020.0265 DOI: https://doi.org/10.1089/pop.2020.0265
  3. S. Onur, M. Çeşme and F. Tümer, Bioorg. Chem., 164, 108916 (2025); https://doi.org/10.1016/j.bioorg.2025.108916 DOI: https://doi.org/10.1016/j.bioorg.2025.108916
  4. S. Waheed, F. Nazakat, N. Abbas, M. Nadeem, S. Ghafoor, G.S. Shabir and A. Saeed, Front. Chem. Sci., 5, 35 (2024); https://doi.org/10.52700/fcs.v5i2.98 DOI: https://doi.org/10.52700/fcs.v5i2.98
  5. Y. Zhang, X. Xu, X. Fan, Y. Wu, X. Zhang, Y. Wu, X. Li and Q. Zou, Front. Pharmacol., 16, 1665421 (2025); https://doi.org/10.3389/fphar.2025.1665421 DOI: https://doi.org/10.3389/fphar.2025.1665421
  6. H. Abbo, D.E. Holman, M.D. Hendricks, C.A. Salubi, M. Keyster and S. Titinchi, Results Chem., 13, 101986 (2025); https://doi.org/10.1016/j.rechem.2024.101986 DOI: https://doi.org/10.1016/j.rechem.2024.101986
  7. H. Azevedo-Barbosa, B.P. do Vale, G. Guidolin Rossi, F. dos Santos Siqueira, K. Bordignon Guterres, M.M. de Campos, T. Dos Santos, J.A. Hawkes, D. Ferreira Dias, S. Neiva Lavorato and T.B. de Souza, Chem. Biodivers., 18, e2100066 (2021); https://doi.org/10.1002/cbdv.202100066 DOI: https://doi.org/10.1002/cbdv.202100066
  8. A. Bouzaheur, A. Bouchoucha, K.S. Larbi and S. Zaater, J. Mol. Struct., 1261, 132811 (2022); https://doi.org/10.1016/j.molstruc.2022.132811 DOI: https://doi.org/10.1016/j.molstruc.2022.132811
  9. D. Dewangan, K.T. Nakhate, D.K. Tripathi, P. Kashyap and H. Dhongde, Anti-Inflamm. Anti-Allergy Agents Med. Chem., 14, 138 (2015); https://doi.org/10.2174/1871523014666150820100212 DOI: https://doi.org/10.2174/1871523014666150820100212
  10. W. Khalid, A. Badshah, A.U. Khan, H. Nadeem and S. Ahmed, Chem. Cent. J., 12, 11 (2018); https://doi.org/10.1186/s13065-018-0378-5 DOI: https://doi.org/10.1186/s13065-018-0378-5
  11. A.K. Yadav, N. Singh, M. Silwal, A. Adhikari and P.N. Yadav, Results Chem., 11, 101794 (2024); https://doi.org/10.1016/j.rechem.2024.101794 DOI: https://doi.org/10.1016/j.rechem.2024.101794
  12. Y. Farrokhi, B. Al-Shibli, D.F. Al-Hameedawi, Z. Neshati and A. Makhdoumi, Res. Microbiol., 172, 103849 (2021); https://doi.org/10.1016/j.resmic.2021.103849 DOI: https://doi.org/10.1016/j.resmic.2021.103849
  13. B.N. Namitha and A. Natarajan, J. Clin. Sci. Res., 12(Suppl. 1), S11 (2023); https://doi.org/10.4103/jcsr.jcsr_87_22 DOI: https://doi.org/10.4103/jcsr.jcsr_87_22
  14. N.A. Tristyaningrum, T. Herlina, L. Heliawati, I.A. Evangelina, D. Nurdin, and D. Kurnia, Results Chem., 18, 102716 (2025); https://doi.org/10.1016/j.rechem.2025.102716 DOI: https://doi.org/10.1016/j.rechem.2025.102716
  15. S.V. Bhuvaneshwari, A.M. Mallikarjunaswamy, K. Gouthami, S. Sekharappa and V. Nair, Indian J. Chem., 63, 1155 (2024); https://doi.org/10.56042/ijc.v63i11.13328 DOI: https://doi.org/10.56042/ijc.v63i11.13328
  16. A.J.M. Xavier, M.A. Raj and J.M. Marie, J. Chem. Pharm. Res., 4, 669 (2012).
  17. L.G. Sarbu, I. Rosca and M.L. Birsa, Antibiotics, 14, 307 (2025); https://doi.org/10.3390/antibiotics14030307 DOI: https://doi.org/10.3390/antibiotics14030307
  18. F. Beyene, A. Mazumder, S. Tadesse, K. Asres and D. Bisrat, Sci. Rep., 15, 39278 (2025); https://doi.org/10.1038/s41598-025-23064-1 DOI: https://doi.org/10.1038/s41598-025-23064-1
  19. R. Kavitha, M.A. Sa'ad, S. Fuloria, N.K. Fuloria, M. Ravichandran and P. Lalitha, Antibiotics, 12, 306 (2023); https://doi.org/10.3390/antibiotics12020306 DOI: https://doi.org/10.3390/antibiotics12020306
  20. J. Drefahl, J. Cheminform., 3, 1 (2011); https://doi.org/10.1186/1758-2946-3-1 DOI: https://doi.org/10.1186/1758-2946-3-1
  21. O. Trott and A.J. Olson, J. Comput. Chem., 31, 455 (2010); https://doi.org/10.1002/jcc.21334 DOI: https://doi.org/10.1002/jcc.21334
  22. A.D. Hunter, J. Chem. Educ., 74, 905 (1997); https://doi.org/10.1021/ed074p905 DOI: https://doi.org/10.1021/ed074p905
  23. N.M. O'Boyle, M. Banck, C.A. James, C. Morley, T. Vandermeersch and G.R. Hutchison, J. Cheminform., 3, 33 (2011); https://doi.org/10.1186/1758-2946-3-33 DOI: https://doi.org/10.1186/1758-2946-3-33
  24. Z.M. Alamshany, R.R. Khattab, N.A. Hassan, A.A. El-Sayed, M.A. Tantawy, A. Mostafa and A.A. Hassan, Molecules, 28, 739 (2023); https://doi.org/10.3390/molecules28020739 DOI: https://doi.org/10.3390/molecules28020739
  25. P. Bhardwaj, G.P. Biswas, N. Mahata, S. Ghanta and B. Bhunia, Chemosphere, 293, 133550 (2022); https://doi.org/10.1016/j.chemosphere.2022.133550 DOI: https://doi.org/10.1016/j.chemosphere.2022.133550
  26. M.A. Sa'ad, R. Kavitha, S. Fuloria, N.K. Fuloria, M. Ravichandran and P. Lalitha, Antibiotics, 11, 207 (2022); https://doi.org/10.3390/antibiotics11020207 DOI: https://doi.org/10.3390/antibiotics11020207
  27. R.F. Muslim, H.M. Tawfeeq, M.N. Owaid and O.H. Abid, Acta Pharm. Sci., 56, 39 (2018); https://doi.org/10.23893/1307-2080.APS.05610 DOI: https://doi.org/10.23893/1307-2080.APS.05610
  28. S. Matam, P. Kaliyan, P. Sethuramasamy and S.P. Muthu, Asian J. Green Chem., 3, 508 (2019); https://doi.org/10.33495/SAMI/AJGC/2019.4.7
  29. K.B. Gangurde, R.A. More, V.A. Adole and D.S. Ghotekar, Results Chem., 7, 101380 (2024); https://doi.org/10.1016/j.rechem.2024.101380 DOI: https://doi.org/10.1016/j.rechem.2024.101380
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