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Synthesis, Characterization, Crystal Structure and Free Radical Scavenging Activities of 2-(2-Butylamine)-6-[(2-butylamine)amino]-5-nitro-1H-benzo[de]-isoquinoline-1,3(2H)-dione
Corresponding Author(s) : Wen Qin
Asian Journal of Chemistry,
Vol. 26 No. 21 (2014): Vol 26 Issue 21
Abstract
2-(2-Butylamine)-6-[(2-butylamine)amino]-5-nitro-1H-benzo[de]-isoquinoline-1,3(2H)-dione (2) was synthesized and then characterized by FT-IR, NMR and elemental analysis. The crystal structure of compound 2 was investigated using X-ray diffraction and SHELXTL97 software and the result indicated that compound 2 crystallized in the monoclinic system, space group C2/c with a = 32.1094 (19), b = 7.1888 (4), c = 16.7750 (9) Å, V = 3827.2 (4) Å3; Z = 8. The free radical scavenging activity screening results showed that compound 2 exhibited good scavenging activity against 2,2-diphenyl-1-picrylhydrazyl radical (DPPH•), with IC50 of 214.7 μM.
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- M.F. Braña and A. Ramos, Curr. Med. Chem. Anticancer Agents, 1, 237 (2001); doi:10.2174/1568011013354624.
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References
M.F. Braña and A. Ramos, Curr. Med. Chem. Anticancer Agents, 1, 237 (2001); doi:10.2174/1568011013354624.
V.K. Malviya, P.Y. Liu, D.S. Alberts, E.A. Surwit, J.B. Craig and E.V. Hannigan, Am. J. Clin. Oncol., 15, 41 (1992); doi:10.1097/00000421-199202000-00009.
C. Behl, Int. J. Vitam. Nutr. Res., 69, 213 (1999); doi:10.1024/0300-9831.69.3.213.
B. Halliwell and J.M.C. Gutteridge, Free Radicals in Biology and Medicine, Oxford University Press: Oxford (1999).
T.W. Stief, Med. Hypotheses, 60, 567 (2003); doi:10.1016/S0306-9877(03)00026-4.
Y. Zhang, S.B. Feng, Q. Wu, K. Wang, X.H. Yi, H.S. Wang and Y.M. Pan, Med. Chem. Res., 20, 752 (2011); doi:10.1007/s00044-010-9384-4.
Y. Zhang, B.Q. Zou, K. Wang, Y.M. Pan, H. Liang, X.H. Yi and H.S. Wang, Med. Chem. Res., 21, 1341 (2012); doi:10.1007/s00044-011-9648-7.
Y. Zhang, B.Q. Zou, K. Wang, Y.M. Pan, H. Liang, X.H. Yi and H.S. Wang, Med. Chem. Res., 21, 1341 (2012); doi:10.1007/s00044-011-9648-7.
W. Qin, Y. Zhang, H.S. Wang and Y. Zhang, Acta Crystallogr., E63, o3995 (2007); doi:10.1107/S160053680704295X.
Y.L. Lee, M.T. Yen and J.L. Mau, Food Chem., 104, 1 (2007); doi:10.1016/j.foodchem.2006.10.063.