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Vol. 26 No. 22 (2014): Vol 26 Issue 22

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Development and Statistical Correlation of Spectrophotometric Methods for Atazanavir Sulfate with Sulphonepthalein Dyes

https://doi.org/10.14233/ajchem.2014.16815
Anindita Behera
School of Pharmaceutical Sciences, Siksha 'O' Anusandhan University, Bharatpur, Ghatikia, Bhubaneswar-751 003, India
Dannana G. Sankar
Pharmaceutical Analysis and Quality Assurance Division, College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530 003, India
Swapan K. Moitra
School of Pharmaceutical Sciences, Siksha 'O' Anusandhan University, Bharatpur, Ghatikia, Bhubaneswar-751 003, India
Sudam C . Si
School of Pharmaceutical Sciences, Siksha 'O' Anusandhan University, Bharatpur, Ghatikia, Bhubaneswar-751 003, India

Corresponding Author(s) : Anindita Behera

anindita02@gmail.com

Asian Journal of Chemistry, Vol. 26 No. 22 (2014): Vol 26 Issue 22

Abstract

Two simple, extraction free spectrophotometric methods are proposed for analysis of protease inhibitor, i.e., atazanavir sulfate. The methods are based on interaction of the drug with 0.1 % chloroformic solutions of acidic sulphonepthalein dyes to form stable yellow coloured ion pair complexes. Two dyes used are bromophenol blue and bromothymol blue. The yellow chromogens are stable and show absorption maxima at 421.9 and 419.4 nm with bromophenol blue and bromothymol blue, respectively. The two chromogens follow the linearity in the range of 5-30 and 10-30 μg/mL for bromophenol blue and bromothymol blue respectively. Both methods are validated according to ICH guidelines and statistically compared.

Keywords

Atazanavir sulfate Bromophenol blue Bromothymol blue Two way ANOVA Student's t-test
Behera, A., G. Sankar, D., K. Moitra, S., & C . Si, S. (2014). Development and Statistical Correlation of Spectrophotometric Methods for Atazanavir Sulfate with Sulphonepthalein Dyes. Asian Journal of Chemistry, 26(22), 7551–7556. https://doi.org/10.14233/ajchem.2014.16815
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References
  1. K. Fukushima, S. Terasaka, K. Haraya, S. Kodera, Y. Seki, A. Wada, Y. Ito, N. Shibata, N. Sugioka and K. Takada, Biol. Pharm. Bull., 30, 733 (2007); doi:10.1248/bpb.30.733.
  2. The Indian Pharmacopoeia, Indian Pharmacopoeia Commission: Ghaziabad, India, Vol. 2, p. 844 (2010).
  3. E.S. Perloff, S.X. Duan, P.R. Skolnik, D.J. Greenblatt and L.L. von Moltke, Drug Metab. Dispos., 33, 764 (2005); doi:10.1124/dmd.104.002931.
  4. R. ter Heine, M. Davids, H. Rosing, E.C.M. van Gorp, J.W. Mulder, Y.T. van der Heide, J.H. Beijnen and A.D.R. Huitema, J. Chromatogr. B, 877, 575 (2009); doi:10.1016/j.jchromb.2009.01.011.
  5. R. ter Heine, H. Rosing, E.C.M. van Gorp, J.W. Mulder, W.A. van der Steeg, J.H. Beijnen and A.D.R. Huitema, J. Chromatogr. B, 867, 205 (2008); doi:10.1016/j.jchromb.2008.04.003.
  6. A. D’Avolio, M. Siccardi, M. Sciandra, B. Lorena, S. Bonora, L. Trentini and G. Di Perri, J. Chromatogr. B, 859, 234 (2007); doi:10.1016/j.jchromb.2007.10.003.
  7. R. ter Heine, C.G. Alderden Los, H. Rosing, M.J.X. Hillebrand, E.C.M. van Gorp, A.D.R. Huitema and J.H. Beijnen, Rapid Commun. Mass Spectrom., 21, 2505 (2007); doi:10.1002/rcm.3119.
  8. L. Dickinson, L. Robinson, J. Tjia, S. Khoo and D. Back, J. Chromatogr. B, 829, 82 (2005); doi:10.1016/j.jchromb.2005.09.032.
  9. T. Koal, H. Burhenne, R. Römling, M. Svoboda, K. Resch and V. Kaever, Rapid Commun. Mass Spectrom., 19, 2995 (2005); doi:10.1002/rcm.2158.
  10. S. Colombo, A. Beguin, A. Telenti, J. Biollaz, T. Buclin, B. Rochat and L.A. Decosterd, J. Chromatogr. B, 819, 259 (2005); doi:10.1016/j.jchromb.2005.02.010.
  11. K.M.L. Crommentuyn, H. Rosing, M.J.X. Hillebrand, A.D.R. Huitema and J.H. Beijnen, J. Chromatogr. B, 804, 359 (2004); doi:10.1016/j.jchromb.2004.01.041.
  12. M. Jemal, S. Rao, M. Gatz and D. Whigan, J. Chromatogr. B, 795, 273 (2003); doi:10.1016/S1570-0232(03)00589-0.
  13. A. Schuster, S. Burzawa, M. Jemal, E. Loizillon, P. Couerbe and D. Whigan, J. Chromatogr. B, 788, 377 (2003); doi:10.1016/S1570-0232(03)00063-1.
  14. D. Cattaneo, F. Maggiolo, D. Ripamonti and N. Perico, J. Chromatogr. Sci., 46, 485 (2008); doi:10.1093/chromsci/46.6.485.
  15. U. Seshachalam, D.V.L.N. Rao, B. Haribabu and K.B. Chandrasekhar, Chromatographia, 65, 355 (2007); doi:10.1365/s10337-006-0155-9.
  16. K. Keil, J. Hochreitter, R. DiFrancesco, B.S. Zingman, R.C. Reichman, M.A. Fischl, B. Gripshover and G.D. Morse, Ther. Drug Monit., 29, 103 (2007); doi:10.1097/FTD.0b013e3180318ef3.
  17. R. Verbesselt, E. van Wijngaerden and J. de Hoon, J. Chromatogr. B, 845, 51 (2007); doi:10.1016/j.jchromb.2006.07.068.
  18. A. Loregian, S. Pagni, E. Ballarin, E. Sinigalia, S.G. Parisi and G. Palu, J. Pharm. Biomed. Anal., 42, 500 (2006); doi:10.1016/j.jpba.2006.04.031.
  19. N.L. Rezk, R.D. Crutchley, R.F. Yeh and A.D.M. Kashuba, Ther. Drug Monit., 28, 517 (2006); doi:10.1097/00007691-200608000-00006.
  20. R.W. Sparidans, F. Dost, K.M.L. Crommentuyn, A.D.R. Huitema, J.H.M. Schellens and J.H. Beijnen, Biomed. Chromatogr., 20, 72 (2006); doi:10.1002/bmc.530.
  21. E. Cateau, N. Tournier, A. Dupuis, G.L. Moal and N. Venisse, J. Pharm. Biomed. Anal., 39, 791 (2005); doi:10.1016/j.jpba.2005.04.025.
  22. O. Tribut, M.C. Verdier, C. Arvieux, H. Allain, C. Michelet and D. Bentue-Ferrer, Ther. Drug Monit., 27, 265 (2005); doi:10.1097/01.ftd.0000162230.83188.32.
  23. J.M. Poirier, P. Robidou and P. Jaillon, Ther. Drug Monit., 27, 186 (2005); doi:10.1097/01.ftd.0000152680.36517.5d.
  24. E. Dailly, F. Raffi and P. Jolliet, J. Chromatogr. B, 813, 353 (2004); doi:10.1016/j.jchromb.2004.10.005.
  25. S. Colombo, N. Guignard, C. Marzolini, A. Telenti, J. Biollaz and L.A. Decosterd, J. Chromatogr. B, 810, 25 (2004); doi:10.1016/j.jchromb.2004.07.008.
  26. S.R. Chitturi, Y.S. Somannavar, B.G. Peruri, S. Nallapati, H.K. Sharma, S.R. Budidet, V.K. Handa and H.B. Vurimindi, J. Pharm. Biomed. Anal., 55, 31 (2011); doi:10.1016/j.jpba.2011.01.002.
  27. S. Dey, Y.V. Reddy, T. Reddy, S.K. Sahoo, P.N. Murthy, S. Mohapatra and S.S. Patro, Int. J. Pharm. Bio. Sci., 1, 1 (2010).
  28. A. Behera, S.K. Moitra, S.C. Si and D.G. Sankar, Quim. Nova, 34, 1349 (2011); doi:10.1590/S0100-40422011000800010.
  29. A. Behera, D.G. Sankar, S.K. Moitra and S.C. Si, E.-J. Chem., 9, 1778 (2012); doi:10.1155/2012/402970.
  30. ICH Guideline, Q2(R1): Validation of Analytical Procedures: Text and Methodology, International Conference on Harmonization, Geneva (2005).
  31. N. Rahman and S.N. Hejaz-Azmi, J. Pharm. Biomed. Anal., 24, 33 (2000); doi:10.1016/S0731-7085(00)00409-X.
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