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Vol. 26 No. 22 (2014): Vol 26 Issue 22

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Synthesis and Antimicrobial Evaluation of Some New 2-(5,6-Dihydro-4H-1,2,4-triazolo[4,3-a]benz[F]azepin-1-yl)methyl)-4-substituted Phthalazin-1(2H)-ones

https://doi.org/10.14233/ajchem.2014.17984
Ibrahim E. El-Shamy
Department of Chemistry, Faculty of Science, Fayoum University, Fayoum, Egypt
A.M. Abdel-Mohsen
Central European Institute of Technology (CEITEC), Brno University of Technology, Brno, Czech Republic
Moustafa M.G. Fouda
Petrochemical Research Chair, Chemistry Department, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia
Salem S. Al-Deyab
Petrochemical Research Chair, Chemistry Department, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia
Ahmed Abdel-Megeed
Plant Protection Department, Faculty of Agriculture, (Saba Basha), Alexandria University, Alexandria, Egypt; Botany and Microbiology Department, College of Science, King Saud University, P.O. Box 2455-Riyadh 11451, Saudi Arabia
Maher A. El-Hashash
Department of Chemistry, Faculty of Science, Ain Shams University, Cairo, Egypt

Corresponding Author(s) : Ibrahim E. El-Shamy

iei00@fayoum.edu.eg

Asian Journal of Chemistry, Vol. 26 No. 22 (2014): Vol 26 Issue 22

Abstract

Starting from 4-substituted-phthalazin-1(2H)-one (1), A series of new 2-(5,6-dihydro-4H-1,2,4-triazolo[4,3-a]benz[f]azepin-1-yl)methyl)-4-substituted phthalazin-1(2H)-ones derivatives (5) have been synthesized. The structure of synthesized new compounds was established by spectral data and screened for their antimicrobial activities against various bacteria and fungi strains.

Keywords

Triazole derivatives Phthalazin Antibacterial activity
E. El-Shamy, I., Abdel-Mohsen, A., M.G. Fouda, M., S. Al-Deyab, S., Abdel-Megeed, A., & A. El-Hashash, M. (2014). Synthesis and Antimicrobial Evaluation of Some New 2-(5,6-Dihydro-4H-1,2,4-triazolo[4,3-a]benz[F]azepin-1-yl)methyl)-4-substituted Phthalazin-1(2H)-ones. Asian Journal of Chemistry, 26(22), 7828–7832. https://doi.org/10.14233/ajchem.2014.17984
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