Issue

Vol. 36 No. 8 (2024): Vol 36 Issue 8, 2024

Copyright (c) 2024 TUSHAR UMASARE, Dr. Sanjay K. Patil, Dr.Jyotsna G. Pargaonkar

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Co(II), Ni(II), Cu(II) and Zn(II) Metal Complexes of Hydrazone Schiff Base Ligand: Synthesis, Characterization, Thermal Behaviour, Antioxidant and Antimicrobial Studies

https://doi.org/10.14233/ajchem.2024.31669
Tushar S. Umasare
Department of Chemistry, Changu Kana Thakur Arts, Commerce and Science College, New Panvel-Raigad, Navi Mumbai-410206, India
https://orcid.org/0000-0002-6794-2030
Sanjay K. Patil
Department of Chemistry, Changu Kana Thakur Arts, Commerce and Science College, New Panvel-Raigad, Navi Mumbai-410206, India
https://orcid.org/0009-0005-1624-2447
Jyotsna G. Pargaonkar
Department of Chemistry, Changu Kana Thakur Arts, Commerce and Science College, New Panvel-Raigad, Navi Mumbai-410206, India
https://orcid.org/0009-0000-1186-2085

Corresponding Author(s) : Tushar S. Umasare

tusharumasare87@gmail.com

Asian Journal of Chemistry, Vol. 36 No. 8 (2024): Vol 36 Issue 8, 2024

Abstract

The metal(II) complexes of ML type of Co(II), Ni(II), Cu(II) and Zn(II) were synthesized using hydrazone Schiff base, N',N"-((1E,2E)-acenaphthylene-1,2-diylidene)bis(2-hydroxy benzohydrazide), which was synthesized by the condensation of acenaphthaquinone and 2-hydroxy benzohydrazide (1:2 molar ratio) in ethanol and characterized by various spectroscopic and analytical techniques, including UV-visible, FTIR, 1H NMR, 13C NMR, LC-MS, TGA-DSC, powder XRD and atomic absorption measurements. The magnetic susceptibility and electronic spectral data suggested that the Ni(II) and Cu(II) complexes have octahedral geometry, while the Co(II) and Zn(II) complexes have tetrahedral geometry. It has also been found that all the metal(II) complexes are paramagnetic, except Zn(II) complex. The molar conductance values indicated that all the metal(II) complexes are non-electrolytes in DMSO solvent. The stability of metal(II) complexes, the absence of coordinated and lattice water molecules in complexes and the proposed formula were all validated by the thermal analysis. All the compounds have average crystallite sizes on the nanoscale, according to powder XRD results. All of the compounds were tested for their in vitro antimicrobial activities against six bacteria (B. subtilis, S. aureus, Corynebacterium, P. aeruginosa, K. pneumoniae and E. coli) and three fungi (C. albicans, A. flavus and A. niger) at two different concentrations.

Keywords

Hydrazone Schiff base Metal(II) complexes Acenaphthaquinone 2-Hydroxy benzohydrazide Biological activities
Umasare, T. S., Patil, S. K., & Pargaonkar, J. G. (2024). Co(II), Ni(II), Cu(II) and Zn(II) Metal Complexes of Hydrazone Schiff Base Ligand: Synthesis, Characterization, Thermal Behaviour, Antioxidant and Antimicrobial Studies. Asian Journal of Chemistry, 36(8), 1781–1792. https://doi.org/10.14233/ajchem.2024.31669
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX
References
  1. C. Boulechfar, H. Ferkous, A. Delimi, A. Djedouani, A. Kahlouche, A. Boublia, A.S. Darwish, T. Lemaoui, R. Verma and Y. Benguerba, Inorg. Chem. Commun., 150, 110451 (2023); https://doi.org/10.1016/j.inoche.2023.110451
  2. A. Subashini, P. Priyadharsani, K. Thamaraiselvi, V. Veeramani, P. Rose, R. Philip, H. Stoeckli-Evans, K. Ramamurthi and R.R. Babu, J. Mater. Sci. Mater. Electron., 30, 2638 (2019); https://doi.org/10.1007/s10854-018-0539-2
  3. A.-A.B.O. Ali, A.J.M. Al-Karawi, N. Dege, S. Kansiz and H.A.D. Ithawi, J. Mol. Struct., 1217, 128387 (2020); https://doi.org/10.1016/j.molstruc.2020.128387
  4. S.A. Aboafia, S.A. Elsayed, A.K.A. El-Sayed and A.M. El-Hendawy, J. Mol. Struct., 1158, 39 (2018); https://doi.org/10.1016/j.molstruc.2018.01.008
  5. I. Al-Qadsy, A.-B. Al-Odayni, W.S. Saeed, A. Alrabie, A. Al-Adhreai, L.A.S. Al-Faqeeh, P. Lama, A.A. Alghamdi and M. Farooqui, Crystals, 11, 110 (2021); https://doi.org/10.3390/cryst11020110
  6. E. Raczuk, B. Dmochowska, J. Samaszko-Fiertek and J. Madaj, Molecules, 27, 787 (2022); https://doi.org/10.3390/molecules27030787
  7. A.-A.B. OmarAli, A.J.M. Al-Karawi, A.A. Awad, N. Dege, S. Kansiz, E. Agar, Z.A. Hussein and I.R. Mohammed, Acta Crystallogr. C Struct. Chem., 76, 476 (2020); https://doi.org/10.1107/S2053229620004994
  8. K. Ananthi, H. Anandalakshmi, A. Nepolraj and S. Akshaya, Substantia, 8, 25 (2024); https://doi.org/10.36253/Substantia-2294
  9. D.A. Tolan, T.I. Kashar, K. Yoshizawa and A.M. El-Nahas, Appl. Organomet. Chem., 35, e6205 (2021); https://doi.org/10.1002/aoc.6205
  10. M. Yadav, S. Sharma and J. Devi, J. Chem. Sci., 133, 21 (2021); https://doi.org/10.1007/s12039-020-01854-6
  11. P. Tyagi, S. Chandra and B. Saraswat, Spectrochim. Acta A Mol. Biomol. Spectrosc., 134, 200 (2015); https://doi.org/10.1016/j.saa.2014.06.112
  12. A A R. Despaigne, G.L. Parrilha, J.B. Izidoro, P.R. da Costa, R.G. dos Santos, O.E. Piro, E.E. Castellano, W.R. Rocha and H. Beraldo, Eur. J. Med. Chem., 50, 163 (2012); https://doi.org/10.1016/j.ejmech.2012.01.051
  13. R. Mohareb, K. El-Sharkawy, M. Hussein and H. El-Sehrawi, J. Pharm. Sci. Res., 2, 185 (2010).
  14. W.B. Júnior, M.S. Alexandre-Moreira, M.A. Alves, A. Perez-Rebolledo, G.L. Parrilha, E.E. Castellano, O.E. Piro, E.J. Barreiro, L.M. Lima and H. Beraldo, Molecules, 16, 6902 (2011); https://doi.org/10.3390/molecules16086902
  15. U. Salgin-Göksen, N. Gökhan-Kelekçi, Ö. Göktas, Y. Köysal, E. Kiliç, S. Isik, G. Aktay and M. Özalp, Bioorg. Med. Chem., 15, 5738 (2007); https://doi.org/10.1016/j.bmc.2007.06.006
  16. O.K. Olurotimi, A.J. Adeyemi, B.O. Agbeke, O. Olajumoke, S.T. Oluwasegun and E.G. Sunday, Orient. J. Chem., 33, 1623 (2017); https://doi.org/10.13005/ojc/330405
  17. W.M. Eldehna, M. Fares, M.M. Abdel-Aziz and H.A. Abdel-Aziz, Molecules, 20, 8800 (2015); https://doi.org/10.3390/molecules20058800
  18. J.R. Dimmock, S.C. Vashishtha and J.P. Stables, Eur. J. Med. Chem., 35, 241 (2000); https://doi.org/10.1016/S0223-5234(00)00123-9
  19. P. Melnyk, V. Leroux, C. Sergheraert and P. Grellier, Bioorg. Med. Chem. Lett., 16, 31 (2006); https://doi.org/10.1016/j.bmcl.2005.09.058
  20. S.V. Bhandari, K.G. Bothara, A.A. Patil, T.S. Chitre, A.P. Sarkate, S.T. Gore, S.C. Dangre and C.V. Khachane, Bioorg. Med. Chem., 17, 390 (2009); https://doi.org/10.1016/j.bmc.2008.10.032
  21. M. Mishra, K. Tiwari, S. Shukla, R. Mishra and V.P. Singh, Spectrochim. Acta A Mol. Biomol. Spectrosc., 132, 452 (2014); https://doi.org/10.1016/j.saa.2014.05.007
  22. P.P. Netalkar, A. Kamath, S.P. Netalkar and V.K. Revankar, Spectrochim. Acta A Mol. Biomol. Spectrosc., 97, 762 (2012); https://doi.org/10.1016/j.saa.2012.07.066
  23. A. Sundar, M. Prabhu, N. Indra Gandhi, M. Marappan and G. Rajagopal, Spectrochim. Acta A Mol. Biomol. Spectrosc., 129, 509 (2014); https://doi.org/10.1016/j.saa.2014.03.084
  24. T. Mistri, M. Dolai, D. Chakraborty, A.R. Khuda-Bukhsh, K.K. Das and M. Ali, Org. Biomol. Chem., 10, 2380 (2012); https://doi.org/10.1039/c2ob07084g
  25. J. Devi, S. Devi and A. Kumar, MedChemComm, 7, 932 (2016); https://doi.org/10.1039/C5MD00554J
  26. M. Jain, S. Maanju and R.V. Singh, Appl. Organomet. Chem., 18, 471 (2004); https://doi.org/10.1002/aoc.711
  27. M. Chinnasamy and A. Ramu, Asian J. Chem., 31, 2941 (2019); https://doi.org/10.14233/ajchem.2019.22308
  28. P.A. Fatullayeva, J. Chemical Problems, 19, 79 (2021); https://doi.org/10.32737/2221-8688-2021-2-79-83
  29. E.S.H. ElAshry, H.A. Hamid, A.A. Kassem and M. Shoukry, Molecules, 7, 155 (2002); https://doi.org/10.3390/70200155
  30. Z. Zhang, H. Yang, G. Wu, Z. Li, T. Song and X.Q. Li, Eur. J. Med. Chem., 46, 3909 (2011); https://doi.org/10.1016/j.ejmech.2011.05.062
  31. Y.S. El-Alawi, B.J. McConkey, D. George Dixon and B.M. Greenberg, Ecotoxicol. Environ. Saf., 51, 12 (2002); https://doi.org/10.1006/eesa.2001.2108
  32. M. Kumar, S. Roy, M.S.H. Faizi, S. Kumar, M.K. Singh, S. Kishor, S.C. Peter and R.P. John, J. Mol. Struct., 1128, 195 (2017); https://doi.org/10.1016/j.molstruc.2016.08.004
  33. R.B. Bennie, S.T. David, C. Joel, S.D. Abraham and S.I. Pillai, Int. J. Inorg. Bioinorg. Chem., 5, 49 (2015).
  34. S.M. Sathyasheeli, S.T. David, C.V. Mythili and P.S. Suja Pon Mini, Der Pharma Chem., 8, 312 (2016).
  35. T.S. Umasare and S.K. Patil, Asian J. Chem., 35, 1932 (2023); https://doi.org/10.14233/ajchem.2023.28058
  36. S. Kumar, A. Hansda, A. Chandra, A. Kumar, M. Sithambaresan, M.S.H. Faizi, M. Kumar, V. Kumar and R.P. John, Polyhedron, 134, 11 (2017); https://doi.org/10.1016/j.poly.2017.05.055
  37. U. El-Ayaan and A.A. Abdel-Aziz, Eur. J. Med. Chem., 40, 1214 (2005); https://doi.org/10.1016/j.ejmech.2005.06.009
  38. S.R. Pattan, P.A. Rabara, J.S. Pattan, A.A. Bukitagar, V.S. Wakale and D.S. Musmade, Indian J. Chem., 48B, 1453 (2009).
  39. I.P. Ejidike and P.A. Ajibade, Molecules, 20, 9788 (2015); https://doi.org/10.3390/molecules20069788
  40. M. Yadav, S. Sharma and J. Devi, J. Chem. Sci., 133, 21 (2021); https://doi.org/10.1007/s12039-020-01854-6
  41. M. Balouiri, M. Sadiki and S.K. Ibnsouda, J. Pharm. Anal., 6, 71 (2016); https://doi.org/10.1016/j.jpha.2015.11.005
  42. M.A. Rizk, M.A. Alsaiari, R.A. Alsaiari, I.A. Ibrahim, A.M. Abbas and G.M. Khairy, Chemosensors, 11, 570 (2023); https://doi.org/10.3390/chemosensors11120570
  43. R.R. Zaky, K.M. Ibrahim and I.M. Gabr, Spectrochim. Acta A Mol. Biomol. Spectrosc., 81, 28 (2011); https://doi.org/10.1016/j.saa.2011.05.028
  44. A. Setyawati, T. D.Wahyuningsih and B. Purwono, AIP Conf. Proc., 1823, 020121 (2017); https://doi.org/10.1063/1.4978194
  45. P. Joshi, S.R. Ali, V.K. Rishu and V.K. Bhardwaj, Luminescence, 36, 986 (2021); https://doi.org/10.1002/bio.4025
  46. T. Mangamamba, M.C. Ganorkar and G. Swarnabala, Int. J. Inorg. Chem., 2014, 736538 (2014); https://doi.org/10.1155/2014/736538
  47. D.S. Badiger, R.S. Hunoor, B.R. Patil, R.S. Vadavi, C.V. Mangannavar, I.S. Muchchandi and K.B. Gudasi, J. Mol. Struct., 1019, 159 (2012); https://doi.org/10.1016/j.molstruc.2012.02.062
  48. A.S. El-Tabl, M. Mohamed Abd El-Waheed, M.A. Wahba and N.A. El-Halim Abou El-Fadl, Bioinorg. Chem. Appl., 2015, 126023 (2015); https://doi.org/10.1155/2015/126023
  49. C. Anitha, S. Sumathi, P. Tharmaraj and C.D. Sheela, Int. J. Inorg. Chem., 2011, 493942 (2011); https://doi.org/10.1155/2011/493942
  50. P. Chelvanathan, Y. Yusoff, F. Haque, M. Akhtaruzzaman, M.M. Alam, Z.A. Alothman, M.J. Rashid, K. Sopian and N. Amin, Appl. Surf. Sci., 334, 138 (2015); https://doi.org/10.1016/j.apsusc.2014.08.155
  51. M.A. Mahmud, N.K. Elumalai, M.B. Upama, D. Wang, F. Haque, C. Xu, M. Wright and A. Uddin, Sol. Energy Mater. Sol. Cells, 167, 70 (2017); https://doi.org/10.1016/j.solmat.2017.03.032
  52. M.O. Agwara, P.T. Ndifon, N.B. Ndosiri, A.G. Paboudam, D.M. Yufanyi and A. Mohamadou, Bull. Chem. Soc. Ethiop., 24, 383 (2010); https://doi.org/10.4314/bcse.v24i3.60680
Read More
Author biographies is not available.
Statistic
Read Counter : 0 Download : 0