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Vol. 36 No. 8 (2024): Vol 36 Issue 8, 2024

Copyright (c) 2024 Panawan Moosophon

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Evaluation of Anticancer Activity of Organo-Montmorillonites and their Plumbagin-Nanohybrids

https://doi.org/10.14233/ajchem.2024.31672
Jirawan Noichan
Natural Products Research Unit, Center of Excellence for Innovation in Chemistry, Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand
https://orcid.org/0009-0003-6645-4638
Nithima Khaorapapong
Materials Chemistry Research Center, Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand
https://orcid.org/0000-0001-5701-0945
Thanaset Senawong
Department of Biochemistry, Khon Kaen University, Khon Kaen 40002, Thailand
https://orcid.org/0000-0001-8788-5291
Panawan Moosophon
Natural Products Research Unit, Center of Excellence for Innovation in Chemistry, Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand
https://orcid.org/0000-0002-3565-1597

Corresponding Author(s) : Panawan Moosophon

mpanaw@kku.ac.th

Asian Journal of Chemistry, Vol. 36 No. 8 (2024): Vol 36 Issue 8, 2024

Abstract

Plumbagin is a naphthoquinone derivative obtained from medicinal plant and displayed cytotoxic activity against several cancer cells. To increase the cytotoxicity of plumbagin on cancer cell lines, it was adsorbed by organo-montmorillonites, used as an adsorbent and prepared by the ion-exchange reaction between three quaternary ammonium surfactants and sodium ion in montmorillonite. Three plumbagin-nanohybrids were successfully synthesized by adsorption of plumbagin in the interlayer space of the organo-montmorillonites and accessed antiproliferation effect on three cancer cells including human colon cancer, human cervical cancer and human breast cancer cell lines and a non-cancer cell line. The organoclays and plumbagin-nanohybrids were characterized by X-ray diffraction, IR and CHN analysis. The combination index (CI) value was used to determine the degree of organo-montmorillonites and plumbagin interaction, indicating a synergistic cytotoxicity between plumbagin and all three organo-montmorillonites on MCF-7 cell proliferation, while they showed additive effect on Vero cell.

Keywords

Plumbagin Montmorillonite Organo-montmorillonite Cytotoxicity
Noichan, J., Khaorapapong, N., Senawong, T., & Moosophon, P. (2024). Evaluation of Anticancer Activity of Organo-Montmorillonites and their Plumbagin-Nanohybrids. Asian Journal of Chemistry, 36(8), 1763–1771. https://doi.org/10.14233/ajchem.2024.31672
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