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Vol. 36 No. 8 (2024): Vol 36 Issue 8, 2024

Copyright (c) 2024 Subhashini N J P, Nagaraju Perike, Praveen Kumar Edigi, Nirmala Gurrapu , Sridhara Devi Nagulapally, Sushmitha bujji

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Synthesis and Characterization of Novel Indole Containing 1,2,3-Triazole Linked 1,3,4-Thiadiazole Hybrids: Evaluation of Anticancer Activity and Molecular Docking Studies

https://doi.org/10.14233/ajchem.2024.32258
Nagaraju Perike
Department of Chemistry, University College of Science, Osmania University, Hyderabad-500007, India
Praveen Kumar Edigi
Department of Chemistry, University College of Science, Osmania University, Hyderabad-500007, India
Nirmala Gurrapu
Department of Chemistry, University College of Science, Osmania University, Hyderabad-500007, India; Department of Chemistry, Telangana Social Welfare Residential Armed Forces Preparatory Degree College, Bhongir-508116, India
https://orcid.org/0009-0002-4167-8355
Sridhara Devi Nagulapally
Department of Chemistry, University College of Science, Osmania University, Hyderabad-500007, India
Sushmitha Bujji
Department of Pharmacy, University College of Technology, Osmania University, Hyderabad-500007, India
https://orcid.org/0000-0002-6422-1545
N.J.P. Subhashini
Department of Chemistry, University College of Science, Osmania University, Hyderabad-500007, India

Corresponding Author(s) : N.J.P. Subhashini

njsubhashini@yahoo.co.in

Asian Journal of Chemistry, Vol. 36 No. 8 (2024): Vol 36 Issue 8, 2024

Abstract

Novel scaffolds containing indole, 1,2,3-triazole linked thiadiazole derivatives (9a-l) were synthesized and confirmed with analytical techniques like 1H NMR, 13C NMR and LC-MS. All the compounds were further screened for their anticancer activity against two cancer cell lines A-549 and MCF-7 by making use of MTT assay and doxorubicin as standard drug. Among the compounds 9c, 9d and 9e demonstrated prominent activity against the tested cancer cell lines A-549 and MCF-7 cell lines compared to doxorubicin. Auto dock Vina of PyRx tool was employed in order to perform molecular docking studies on ERK2. Interestingly, the binding energies and interactions acquired from docking results of compounds are in accordance with the investigatory data.

Keywords

Indole 1,2,3-Triazole 2-Aminothiadiazole Anticancer Molecular docking
Perike, N., Edigi, P. K., Gurrapu, N., Nagulapally, S. D., Bujji, S., & Subhashini, N. (2024). Synthesis and Characterization of Novel Indole Containing 1,2,3-Triazole Linked 1,3,4-Thiadiazole Hybrids: Evaluation of Anticancer Activity and Molecular Docking Studies. Asian Journal of Chemistry, 36(8), 1946–1952. https://doi.org/10.14233/ajchem.2024.32258
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