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Vol. 36 No. 7 (2024): Vol 36 Issue 7, 2024

Copyright (c) 2024 VAIBHAV V. POTDAR, Dr. Arun B.Joshi

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis, Antibacterial Screening and ADME Prediction of Novel Ester Derivatives of 6-Substituted-2-chloroquinoline-3-carbaldehyde

https://doi.org/10.14233/ajchem.2024.31503
Vaibhav V. Potdar
Goa College of Pharmacy (Affliated to Goa University), Panaji-403001, India
https://orcid.org/0009-0008-1379-1872
Arun B. Joshi
Goa College of Pharmacy (Affliated to Goa University), Panaji-403001, India
Himanshu Joshi
College of Pharmacy, Graphic Era Hill University, Bhimtal campus, Bhimtal, Nainital-263139, India

Corresponding Author(s) : Vaibhav V. Potdar

potdarvaibhavv@gmail.com

Asian Journal of Chemistry, Vol. 36 No. 7 (2024): Vol 36 Issue 7, 2024

Abstract

In this research, a series of novel 2-chloroquinoline-3-carbaldehyde analogues (4a-f) were successfully synthesized by employing several acetanilides in combination with hydrazides and acyl chlorides. The methodology yielded compounds with distinct substitutions, thus expanding the chemical diversity of this class of compounds. Characterization through FT-IR, 1H NMR, 13C NMR and mass spectral analysis confirmed the structural integrity of the synthesized derivatives. The ADME study indicates that the synthesized compounds were found to be possessing reliable ADME properties. The antimicrobial properties were tested against bacterial species with ciprofloxacin as standard drug. These newly synthesized compounds hold promise for further exploration of their biological activities and pharmacological profiles, making them valuable candidates for future research in the quest for novel therapeutic agents.

Keywords

Acetanilide 2-Chloroquinoline-3-carbaldehyde Vilsmeier-Haack reaction Acyl chloride Hydrazide
Potdar, V. V., Joshi, A. B., & Joshi, H. (2024). Synthesis, Antibacterial Screening and ADME Prediction of Novel Ester Derivatives of 6-Substituted-2-chloroquinoline-3-carbaldehyde. Asian Journal of Chemistry, 36(7), 1518–1522. https://doi.org/10.14233/ajchem.2024.31503
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