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Vol. 36 No. 7 (2024): Vol 36 Issue 7, 2024

Copyright (c) 2024 NOR AHMAD, Dr. Nor’ Aishah Hasan, Miss Nurul Natasha Wazir, Dr Nurhamimah Zainal-Abidin, Mohd Zaini Nawahwi, Miss Nurul Atikah Badrol Hisham, Prof Yamin Yasin, Dr. Nik Rozlin Nik Masdek, Jasmine Elanie Khairat, Lim Zhi Yu, Dr. Azzreena Mohamad Azzeme, Dr. Gusliani Eka Putri, Prof. Syukri Arief

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Antibacterial and Antiviral Potential of Zirconium Oxide Nanoparticle using Extract of Chloranthus erectus Leaf

https://doi.org/10.14233/ajchem.2024.31775
Nor' Aishah Hasan
School of Biology, Faculty of Applied Sciences, Universiti Teknologi MARA, Cawangan Negeri Sembilan, Kampus Kuala Pilah, 72000 Kuala Pilah, Malaysia
https://orcid.org/0000-0003-1945-1170
Nurul Natasha Wazir
School of Biology, Faculty of Applied Sciences, Universiti Teknologi MARA, Cawangan Negeri Sembilan, Kampus Kuala Pilah, 72000 Kuala Pilah, Malaysia
Nurhamimah Zainal-Abidin
School of Biology, Faculty of Applied Sciences, Universiti Teknologi MARA, Cawangan Negeri Sembilan, Kampus Kuala Pilah, 72000 Kuala Pilah, Malaysia
https://orcid.org/0000-0003-2315-4574
Mohd Zaini Nawahwi
School of Biology, Faculty of Applied Sciences, Universiti Teknologi MARA, Cawangan Negeri Sembilan, Kampus Kuala Pilah, 72000 Kuala Pilah, Malaysia
https://orcid.org/0000-0003-0289-3044
Nurul Atikah Badrol Hisham
School of Chemistry and Environment, Faculty of Applied Sciences, Universiti Teknologi MARA, Cawangan Negeri Sembilan, Kampus Kuala Pilah, 72000 Kuala Pilah, Malaysia
Yamin Yasin
School of Chemistry and Environment, Faculty of Applied Sciences, Universiti Teknologi MARA, Cawangan Negeri Sembilan, Kampus Kuala Pilah, 72000 Kuala Pilah, Malaysia
Nik Rozlin Nik Masdek
School of Mechanical Engineering,College of Engineering 40450 UiTM,Shah Alam, Selangor, Malaysia
https://orcid.org/0009-0004-8355-622X
Jasmine Elanie Khairat
Institute of Biological Sciences, Faculty of Science, Universiti Malaya, Kuala Lumpur 50603, Malaysia
https://orcid.org/0000-0001-9419-5731
Lim Zhi Yu
Institute of Biological Sciences, Faculty of Science, Universiti Malaya, Kuala Lumpur 50603, Malaysia
Azzreena Mohamad Azzeme
Department of Biochemistry, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
https://orcid.org/0000-0003-4117-1220
Syukri Arief
Faculty of Mathematics and Natural Sciences, Andalas University, Padang, Indonesia
https://orcid.org/0000-0001-8730-1401
Gusliani Eka Putri
Department of Medical Laboratory Technology, Syedza Saintika College of Health Sciences, Padang, Indonesia
https://orcid.org/0000-0003-1596-6273
Nor Monica Ahmad
School of Chemistry and Environment, Faculty of Applied Sciences, Universiti Teknologi MARA, Cawangan Negeri Sembilan, Kampus Kuala Pilah, 72000 Kuala Pilah, Malaysia
https://orcid.org/0000-0002-9333-8398

Corresponding Author(s) : Nor Monica Ahmad

normonica@gmail.com

Asian Journal of Chemistry, Vol. 36 No. 7 (2024): Vol 36 Issue 7, 2024

Abstract

Zirconium oxide nanoparticles (ZrO2 NPs) were synthesized with an effective capping agent using aqueous extract of Chlorentus erectus at the optimized conditions. The aqueous leaf extract contained phytochemical compounds that could regulate the size and shape of the nanoparticles. The average size of C. erectus-ZrO2 NPs crystallite was 10.42 nm, which was determined based on Scherrer Debye’s equation. The finding indicated the effectiveness of the phytochemical compounds to diminish the agglomeration of the particles. The C. erectus mediated ZrO2 NPs were in spherical clusters when observed through a transmission electron microscope (TEM). An elemental energy diffraction X-ray (EDX) assessment also revealed a significant zirconium and oxygen percentage, suggesting that the phytochemicals present in the leaf extract did not alter the purity of C. erectus-ZrO2 NPs. Moreover, 200 µg/mL of synthesized ZrO2 NPs effectively inhibited K. pneumoniae. Up to 300 µg/mL of C. erectus- ZrO2 NPs demonstrated non-toxicity to vero cells and low antiviral properties against the DENV-2 virus when introduced to cells post-infection.

Keywords

Capping agent Chlorentus erectus Nanoparticles Synthesis Zirconium oxide
Hasan, N. A., Wazir, N. N., Zainal-Abidin, N., Nawahwi, M. Z., Badrol Hisham, N. A., Yasin, Y., … Ahmad, N. M. (2024). Antibacterial and Antiviral Potential of Zirconium Oxide Nanoparticle using Extract of Chloranthus erectus Leaf. Asian Journal of Chemistry, 36(7), 1705–1712. https://doi.org/10.14233/ajchem.2024.31775
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