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Vol. 36 No. 7 (2024): Vol 36 Issue 7, 2024

Copyright (c) 2024 Tanjima laskar tarique

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A Divergent Synthesis and in vitro Biological Evaluation of Novel Pyrazolyl Chalcones and Pyrazolyl Flavones

https://doi.org/10.14233/ajchem.2024.31722
Tanjima Tarique Laskar
Department of Pharmaceutical Sciences, University of Science and Technology Meghalaya, Ri-Bhoi, Baridua-793101, India
https://orcid.org/0000-0002-6098-0114

Corresponding Author(s) : Tanjima Tarique Laskar

tanjimatarique.12@gmail.com

Asian Journal of Chemistry, Vol. 36 No. 7 (2024): Vol 36 Issue 7, 2024

Abstract

A total of sixteen flavonoids, eight each of pyrazolyl chalcones [IM-3(a-h)] and pyrazolyl flavones [IM-4(a-h)] were synthesized and tested for in vitro antidiabetic, antiarthritic, anticoagulant, anthelmintic, anti-inflammatory and antioxidant activities by various methods such as α-amylase inhibitory method, egg albumin denaturation method, prothrombin time method, paralysis and death time method, bovine serum denaturation method and DPPH radical scavenging activity method, respectively. Structural analysis of the synthesized chalcone and flavone derivatives was carried out by various characterization techniques such as IR, 1H NMR, 13C NMR, LC-MS and elemental analysis. Out of all the synthesized derivatives IM-3a containing dibenzyloxy groups had displayed the most promising activity in all the in vitro analysis with IC50 value ranging from 59.33 ± 10.26-144.44 ± 11.16 µg/mL. Compound IM-3a may prove to be a potential therapeutic option owing to its strong antidiabetic, antiarthritic, anticoagulant, anthelmintic, anti-inflammatory and and antioxidant properties.

Keywords

Antidiabetic Antiarthritic Anticoagulant Anthelmintic Anti-inflammatory Antioxidant
Laskar, T. T. (2024). A Divergent Synthesis and in vitro Biological Evaluation of Novel Pyrazolyl Chalcones and Pyrazolyl Flavones. Asian Journal of Chemistry, 36(7), 1672–1680. https://doi.org/10.14233/ajchem.2024.31722
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