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Vol. 36 No. 7 (2024): Vol 36 Issue 7, 2024

Copyright (c) 2024 G. K. AYYADURAI, S. RATHIKA, S. SUMATHI, R. JAYAPRAKASH

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Theoretical, Antibacterial and Antioxidant Investigations of Hydroxyl Group Substituted Benzanilide Schiff Bases

Biological activities of schiff bases
https://doi.org/10.14233/ajchem.2024.31757
G.K. Ayyadurai
Department of Chemistry, Sri Sairam Engineering College, Sai Leo Nagar, West Tambaram, Chennai-600044, India
https://orcid.org/0000-0003-4836-4383
S. Rathika
Department of Chemistry, Sri Sairam Institute of Technology, Sai Leo Nagar, West Tambaram, Chennai-600044, India
https://orcid.org/0000-0001-8987-6129
S. Sumathi
Department of Chemistry, Sri Sairam Institute of Technology, Sai Leo Nagar, West Tambaram, Chennai-600044, India
https://orcid.org/0000-0001-8179-5893
R. Jayaprakash
Department of Chemistry, School of Arts and Science, Vinayaka Mission’s Chennai Campus, Vinayaka Mission’s Research Foundation (Deemed University), Paiyanoor, Chennai-603104, India
https://orcid.org/0000-0002-4323-4910

Corresponding Author(s) : R. Jayaprakash

jayaprakashsangee1977@gmail.com

Asian Journal of Chemistry, Vol. 36 No. 7 (2024): Vol 36 Issue 7, 2024

Abstract

Two novel Schiff bases were synthesized from 4-amino-N-(4-aminophenyl)benzamide (DABA) and investigated after the spectral characterization techniques. Density functional theory (DFT) and molecular docking studies were conducted initially for the molecules for drug suitability. The toxicity of the synthesized molecules was evaluated using brine shrimp and 50% mortality concentrations of both the Schiff bases were examined with standard vincristine sulphate. Then, the antimicrobial activity was studied against selected bacterial strains such as E. coli, K. pneumoniae, S. typhimurium and P. mirabilis. The biological efficacy also extended to antioxidant study and the results showed that the inhibition concentrations between 150 and 305 µg/mL, which are in the toxicity limit. Out of two molecules, 2,4-dihydroxy group substituted Schiff bases showed better antimicrobial, antidiabetic and antioxidant activities.

Keywords

Benzanilide Schiff bases DFT Docking Biological efficacy
Ayyadurai, G., Rathika, S., Sumathi, S., & Jayaprakash, R. (2024). Theoretical, Antibacterial and Antioxidant Investigations of Hydroxyl Group Substituted Benzanilide Schiff Bases: Biological activities of schiff bases. Asian Journal of Chemistry, 36(7), 1601–1608. https://doi.org/10.14233/ajchem.2024.31757
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