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Vol. 36 No. 6 (2024): Vol 36 Issue 6, 2024

Copyright (c) 2024 Jyotindra Mahyavanshi

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Synthesis, Structural Determination, Docking Study and Bioactivity of Novel Thiophene Derivatives

https://doi.org/10.14233/ajchem.2024.31509
Jyotindra Mahyavanshi
Department of Chemistry, R.R. Mehta Science and C.L. Parikh Commerce College, Palanpur (Affiliated to Hemchandracharya North Gujarat University), Palanpur-385001, India
https://orcid.org/0000-0003-4523-5674
Snehal Lokhandwala
Department of Environmental Science & Technology, UPL University of Sustainable Technology, Ankleshwar-393135, India
https://orcid.org/0000-0001-5657-6912
Jayesh Pandya
Research and Development Division, Suyog Life Sciences Pvt. Ltd., Ankleshwar-393002, India
https://orcid.org/0009-0007-4597-3315
Jigar Patel
Department of Chemistry, Shri P.J. Patel Nilkanth Science College, Maktupur-384170, India
https://orcid.org/0000-0002-2630-0066

Corresponding Author(s) : Jyotindra Mahyavanshi

mjyotindra44@gmail.com

Asian Journal of Chemistry, Vol. 36 No. 6 (2024): Vol 36 Issue 6, 2024

Abstract

The present study reveals 4-methyl-3-(propylamino)thiophene-2-carboxylic acid (Articaine acid) as precursor derivative to synthesize novel thiophene compounds to evaluate their biological activity. The synthesized compounds were subjected to comprehensive characterization techniques including mass spectra, NMR and IR spectroscopy, confirming their structural integrity. Their antimicrobial activity was assessed via minimum inhibitory concentration (MIC) assay against selected bacterial strains. The results emphasize the potential therapeutic applications of these thiophene analogues as efficacious antimicrobial agents, thereby encouraging further investigation. Molecular docking was used to examine thiophene derivative binding affinities on the S. aureus tyrosyl-tRNA synthetase protein and it was found that phenylethylamine derivatives had the highest binding affinity, followed by cyclohexyl methyl and benzylamine derivatives.

Keywords

Thiophene derivatives Structure-activity relationship Antimicrobial agents Drug discovery
Mahyavanshi, J., Lokhandwala, S., Pandya, J., & Patel, J. (2024). Synthesis, Structural Determination, Docking Study and Bioactivity of Novel Thiophene Derivatives. Asian Journal of Chemistry, 36(6), 1321–1326. https://doi.org/10.14233/ajchem.2024.31509
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