Issue

Vol. 36 No. 6 (2024): Vol 36 Issue 6, 2024

Copyright (c) 2024 Dr. Aminabee Shaik

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis, Characterization and Evaluation of Modified Starches Derived from Tapioca Starch

https://doi.org/10.14233/ajchem.2024.31407
K.N.V. Chenchu Lakshmi
Department of Pharmaceutical Chemistry, K.V.S.R. Siddhartha College of Pharmaceutical Sciences, Vijayawada-520008, India
https://orcid.org/0000-0001-9422-7959
Shaik Aminabee
Department of Pharmacology, V.V. Institute of Pharmaceutical Sciences, Gudlavalleru-521356, India
https://orcid.org/0000-0001-9256-0897
K. Ravi Shankar
Department of Pharmaceutical Chemistry, K.V.S.R. Siddhartha College of Pharmaceutical Sciences, Vijayawada-520008, India
https://orcid.org/0000-0001-7464-1896
D. Chaithanya Sudha Penta
Department of Pharmacology, Krupanidhi College of Pharmacy, Bengaluru-560035, India
https://orcid.org/0000-0003-4946-8010
G. Indusree
Department of Pharmaceutical Chemistry, K.V.S.R. Siddhartha College of Pharmaceutical Sciences, Vijayawada-520008, India
https://orcid.org/0009-0009-3549-012X
M. Sushmasri
Department of Pharmaceutical Chemistry, K.V.S.R. Siddhartha College of Pharmaceutical Sciences, Vijayawada-520008, India
https://orcid.org/0009-0000-4588-3976
M. Tejaswi
Department of Pharmaceutical Chemistry, K.V.S.R. Siddhartha College of Pharmaceutical Sciences, Vijayawada-520008, India
https://orcid.org/0009-0008-7176-686X
M. Sampath Pavan
Department of Pharmaceutical Chemistry, K.V.S.R. Siddhartha College of Pharmaceutical Sciences, Vijayawada-520008, India
https://orcid.org/0009-0004-9776-4935
M. Kiran
Department of Pharmaceutical Chemistry, Shri Vishnu College of Pharmacy, Bhimavaram-534202, India
https://orcid.org/0000-0002-8289-2879
V. Girija Sastry
Department of Pharmaceutical Chemistry, A.U. College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, India
https://orcid.org/0000-0001-6250-8473

Corresponding Author(s) : Shaik Aminabee

aminaammi786@gmail.com

Asian Journal of Chemistry, Vol. 36 No. 6 (2024): Vol 36 Issue 6, 2024

Abstract

Over the past few decades, progressions in the preparation of starch-derived products from a variety of biodiverse sources have yielded substances with novel or improved characteristics. Present work focus on modification of tapioca starch by acids and anhydrides. Around 11 modified starches were synthesized using 9 acids and 2 anhydrides and characterized by FTIR spectroscopy and also their swelling property was also determined. For the optimization of molecular geometry, the HOMO and the LUMO modelling for initial starch and modified starch was performed by GAMES 64 software. Orbital investigations have revealed that the modified starch succinate form has an energy gap of 197 eV, indicating a loss in energy. This decrease in the energy of anhydride after reacting with starch shows the stability and absence of orbitals at the reaction site. Using modified starch, olmesartan tablets were formulated and compared with tablets prepared by crospovidone and croscarmellose sodium. In each instance, two distinct concentrations of the superdisintegrant (2% and 4%) were employed. Olmesartan tablets formulated dissolution rate adhered to first-order kinetics which was evidenced by R2 values exceeding 0.940 across all the experiments. Notably, in the dissolution rate study, the modified starch exhibited rapid and enhanced dissolution of olmesartan from the tablets, comparable to the performance of commercial available super-disintegrants such as croscarmellose sodium and crospovidone.

Keywords

HOMO and LUMO modeling Modified starch Super disintegrant
Lakshmi, K. C., Aminabee, S., Shankar, K. R., Sudha Penta, D. C., Indusree, G., Sushmasri, M., … Sastry, V. G. (2024). Synthesis, Characterization and Evaluation of Modified Starches Derived from Tapioca Starch. Asian Journal of Chemistry, 36(6), 1295–1300. https://doi.org/10.14233/ajchem.2024.31407
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX
References
  1. Q. Chen, H. Yu, L. Wang, Z. ul Abdin, Y. Chen, J. Wang, W. Zhou, X. Yang, R.U. Khan, H. Zhang and X. Chen, RSC Adv., 5, 67459 (2015); https://doi.org/10.1039/C5RA10849G
  2. M. Haroon, L. Wang, H. Yu, N.M. Abbasi, Z.-A. Zain-ul-Abdin, M. Saleem, R.U. Khan, R.S. Ullah, Q. Chen and J. Wu, RSC Adv., 6, 78264 (2016); https://doi.org/10.1039/C6RA16795K
  3. M.A. Otache, R.U. Duru, O. Achugasim and O.J. Abayeh, J. Polym. Environ., 29, 1379 (2021); https://doi.org/10.1007/s10924-020-02006-0
  4. Y. Fan and F. Picchioni, Carbohydr. Polym., 241, 116350 (2020); https://doi.org/10.1016/j.carbpol.2020.116350
  5. J. Compart, A. Singh, J. Fettke and A. Apriyanto, Polymers, 15, 3491 (2023); https://doi.org/10.3390/polym15163491
  6. M.Y. Naz, S.A. Sulaiman, B. Ariwahjoedi and K.Z. Shaari, Scientific World J., 14, 375206 (2014); https://doi.org/10.1155/2014/375206
  7. E. Ojogbo, E.O. Ogunsona, T.H. Mekonnen, Mater. Today Sustain., 7-8, 100028 (2020); https://doi.org/10.1016/j.mtsust.2019.100028
  8. S. Suri and A. Singh, Sustain. Food Technol., 1, 348 (2023); https://doi.org/10.1039/D2FB00043A
  9. Y. Fu, E. Jiang and Y. Yao, Annu. Rev. Food Sci. Technol., 25 , 117 (2022); https://doi.org/10.1146/annurev-food-102821-035457
  10. N. Masina, Y.E. Choonara, P. Kumar, L.C. du Toit, M. Govender, S. Indermun and V. Pillay, Carbohydr. Polym., 157, 1236 (2017); https://doi.org/10.1016/j.carbpol.2016.09.094
  11. H. Nawaz, R. Waheed, M. Nawaz and D. Shahwar, Physical and Chemical Modifications in Starch Structure and Reactivity, In: Chemical Properties of Starch, IntechOpen, vol. 9, pp. 13-34 (2020).
  12. R.S. Ayu, A. Khalina, A.S. Harmaen, K. Zaman, M. Jawaid and C.H. Lee, Polymers, 10, 1187 (2018); https://doi.org/10.3390/polym10111187
  13. M. Emeje and A. Rodrigues, in eds.: B. Valdez, Starch: From Food to Medicine, Scientific, Health and Social Aspects of the Food Industry, vol. 20, pp. 355-380 (2012).
  14. M.-G. Dorantes-Fuertes, M.C. López-Méndez, G. Martínez-Castellanos, R.Á. Meléndez-Armenta and H.-E. Jiménez-Martínez, Agronomy, 14, 865 (2024); https://doi.org/10.3390/agronomy14040865
  15. S.M. Amaraweera, C. Gunathilake, O.H. Gunawardene, N.M. Fernando, D.B. Wanninayaka, R.S. Dassanayake, S.M. Rajapaksha, A. Manamperi, C.A.N. Fernando, A.K. Kulatunga and A. Manipura, Molecules, 26, 6880 (2021); https://doi.org/10.3390/molecules26226880
  16. N. Javadian, A. Mohammadi Nafchi and M. Bolandi, Food Sci. Nutr., 9, 5467 (2021); https://doi.org/10.1002/fsn3.2506
  17. Y. Xu, Q. Chu, D. Chen and A. Fuentes, Frontiers Mechanical Eng., 7, 744001 (2021); https://doi.org/10.3389/fmech.2021.744001
  18. O.A. Adetunji and O. Kolawole, Nigerian J. Pharm. Res., 14, 15 (2018).
  19. H. Nawaz, M.A. Shad, S. Saleem, M.U. Khan, U. Nishan, T. Rasheed, M. Bilal and H.M. Iqbal, Int. J. Biol. Macromol., 113, 219 (2018); https://doi.org/10.1016/j.ijbiomac.2018.02.125
  20. L. David, A. Thakkar, R. Mercado and O. Engkvist, J. Cheminform., 12, 56 (2020); https://doi.org/10.1186/s13321-020-00460-5
  21. A. Okunlola, East Cent. Afr. J. Pharm. Sci., 23, 104 (2020).
  22. V. Vamadevan and E. Bertoft, Food Hydrocoll., 103, 105663 (2020); https://doi.org/10.1016/j.foodhyd.2020.105663
  23. C. Pozo, S. Rodríguez-Llamazares, R. Bouza, L. Barral, J. Castano, N. Müller and I. Restrepo, J. Polym. Res., 25, 266 (2018); https://doi.org/10.1007/s10965-018-1651-y
  24. L. Lachman, A. Lieberman and J.L. Kinig, The Theory and Practice of Industrial Pharmacy,Varghese Publishing House, Delhi, India, pp. 67-68 (1991).
  25. S.K. Battu, M.A. Repka, S. Majumdar and M. Rao, Drug Dev. Ind. Pharm., 33, 1225 (2007); https://doi.org/10.1080/03639040701377888
Read More
Author biographies is not available.
Statistic
Read Counter : 0 Download : 0