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Vol. 36 No. 5 (2024): Vol 36 Issue 5, 2024

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Multi-Step Synthesis, Characterization and Bioevaluation of Novel 2-(3-Methoxy-9H-carbazol-9-yl)-N-phenyl Acetamide Analogues

https://doi.org/10.14233/ajchem.2024.30962
Visweswara Rao Ch.
Department of Chemistry, GITAM School of Science, GITAM (Deemed to be University), Visakhapatnam-530045, India
https://orcid.org/0009-0008-4194-1591
Lakshman Shaik
Department of Chemistry, GITAM School of Science, GITAM (Deemed to be University), Visakhapatnam-530045, India
https://orcid.org/0009-0003-7032-0114

Corresponding Author(s) : Lakshman Shaik

lshaik@gitam.edu

Asian Journal of Chemistry, Vol. 36 No. 5 (2024): Vol 36 Issue 5, 2024

Abstract

In this work, the multi-step synthesis and characterization of novel 2-(3-methoxy-9H-carbazol-9-yl)-N-phenyl acetamide analogues is presented. These analogues were synthesized from 2-(3-methoxy-9H-carbzol-9-yl)acetyl chloride with substituted aromatic primary amines in the presence of organic base such as triethylamine and methylene dichloride under reflux conditions. The elemental analysis and structures of these novel compounds were elucidated by analyzing spectral data obtained through 1H NMR, 13C NMR and LCMS techniques. The bioevaluation of these newly synthesized compounds has been studied by evaluating their antibacterial and antifungal activities against various kinds of bacterial and fungal strains, respectively.

Keywords

Synthesis 1,2-Dichloro benzene 3-Methoxy-9H-carbazole Substituted aniline
Rao Ch., V., & Shaik, L. (2024). Multi-Step Synthesis, Characterization and Bioevaluation of Novel 2-(3-Methoxy-9H-carbazol-9-yl)-N-phenyl Acetamide Analogues. Asian Journal of Chemistry, 36(5), 1040–1044. https://doi.org/10.14233/ajchem.2024.30962
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