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Vol. 36 No. 4 (2024): Vol 36 Issue 4, 2024

Copyright (c) 2024 Dr.Parameshwara P Naik, Shridhar. P. Melkeri, Dr. N.D.Satyanarayan, G. Krishnamurthy, Prabhakar W. Chavan, Itte Pushpathi

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Synthesis and Characterization of Biopotent Transition Metal Complexes of Schiff Base 2-{(1)-1-[2-(1,3-Benzothiazol-2-yl)hydrazinylidene]ethyl}-6,10b-dihydro-3H-benzo[f]chromen-3-one and their Biological Evaluation

https://doi.org/10.14233/ajchem.2024.31148
Shridhar P. Melkeri
Department of Chemistry, Sahyadri Science College, Kuvempu University, Shivamogga-577203, India
P. Parameshwara Naik
Department of Chemistry, Sahyadri Science College, Kuvempu University, Shivamogga-577203, India
https://orcid.org/0000-0001-7534-3794
N.D. Satyanarayan
Department of P.G. Studies and Research in Chemistry, P.G. Centre, Kadur-577458, India
https://orcid.org/0000-0003-4511-3749
Itte Pushpavathi
Department of Industrial Chemistry, Kuvempu University, Shankaraghatta-577451, India
https://orcid.org/0000-0002-5292-7858
G. Krishnamurthy
Department of Chemistry, Sahyadri Science College, Kuvempu University, Shivamogga-577203, India
https://orcid.org/0000-0002-1009-0797
Prabhakar W. Chavan
Department of Chemistry, Sahyadri Science College, Kuvempu University, Shivamogga-577203, India
https://orcid.org/0000-0001-8326-7154

Corresponding Author(s) : P. Parameshwara Naik

parashchem@gmail.com

Asian Journal of Chemistry, Vol. 36 No. 4 (2024): Vol 36 Issue 4, 2024

Abstract

Three transition metal(II) complexes (M = Co/ Zn/Pd) were synthesized by using a newly synthesized Schiff base ligand 2-{(1E)-1-[2-(1,3-benzothiazol-2-yl)hydrazinylidene]ethyl}-6,10b-dihydro-3H-benzo[f]chromen-3-one (L) by conventional method. The structure of the compounds were determined by physical and analytical techniques like UV-visible, FT-IR, 1H and 13C NMR and mass spectroscopic techniques and the crystallinity and inter-planar distance of the complexes were confirmed by XRD. The electron density in HOMO and LUMO was determined by DFT studies. The studies of electronic spectra and measurements of magnetic susceptibility suggest that Co(II) complex shows an octahedral geometry, Pd(II) complexes show square planar geometry and (ZnL2Cl2) complex shows tetrahedral geometry. The molar conductivity results suggested the non-electrolytic nature of the metal(II) complexes. The synthesized compounds was tested against antibacterial activity for Gram-positive and Gram-negative bacteria. The molecular docking study demonstrated that the ligand and its metal(II) complexes possess antibacterial and anticancer properties, and the results showed that the compounds were effective against the microorganisms that were examined. Furthermore, the results found that metal(II) complexes provided enhanced immunity against cancer cell lines.

Keywords

Transition metal chelates Schiff bases Antimicrobial activities Molecular docking studies
Melkeri, S. P., Naik, P. P., Satyanarayan, N., Pushpavathi, I., Krishnamurthy, G., & Chavan, P. W. (2024). Synthesis and Characterization of Biopotent Transition Metal Complexes of Schiff Base 2-{(1)-1-[2-(1,3-Benzothiazol-2-yl)hydrazinylidene]ethyl}-6,10b-dihydro-3H-benzo[f]chromen-3-one and their Biological Evaluation. Asian Journal of Chemistry, 36(4), 844–850. https://doi.org/10.14233/ajchem.2024.31148
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References
  1. S. Naik, P.P. Naik, G. Krishnamurthy, N. Venugopal, N. Naik and T.R. Naik, J. Inorg. Organomet. Polym. Mater., 30, 3332 (2020); https://doi.org/10.1007/s10904-020-01492-y
  2. S.A. Elsayed, H.M. El Gharabawy, I.S. Butler and F.M. Atlam, Appl. Organomet. Chem., 34, e5643 (2020); https://doi.org/10.1002/aoc.5643
  3. S.J.S. Flora and V. Pachauri, Int. J. Environ. Res. Public Health, 7, 2745 (2010); https://doi.org/10.3390/ijerph7072745
  4. A.J. Waldman, T.L. Ng, P. Wang and E.P. Balskus, Chem. Rev., 117, 5784 (2017); https://doi.org/10.1021/acs.chemrev.6b00621
  5. V.G. Tsirelson and R.P. Ozerov, J. Mol. Struct. (Theochem.), 255, 335 (1992); https://doi.org/10.1016/0166-1280(92)85020-L
  6. M.A. Malik, O.A. Dar, P. Gull, M.Y. Wani and A.A. Hashmi, Medchemcomm, 9, 409 (2018); https://doi.org/10.1039/c7md00526a
  7. R. Kumar, A.A. Singh, U. Kumar, P. Jain, A.K. Sharma, C. Kant and M.S.H. Faizi, J. Mol. Struct., 1294, 136346 (2023); https://doi.org/10.1016/j.molstruc.2023.136346
  8. K.M. Khan, Z.S. Saify, M.Z. Khan, Zia-Ullah, M.I. Choudhary, Atta-ur-Rahman, S. Perveen, Z.H. Chohan and C.T. Supuran, J. Enzyme Inhib. Med. Chem., 19, 373 (2004); https://doi.org/10.1080/14756360409162453
  9. J.C. Logan, M.P. Fox, J.H. Morgan, A.M. Makohon and C.J. Pfau, J. Gen. Virol., 28, 271 (1975); https://doi.org/10.1099/0022-1317-28-3-271
  10. S.M. Gomha and H.M. Abdel-Aziz, J. Chem. Res., 37, 298 (2013); https://doi.org/10.3184/174751913X13662197808100
  11. H.A. El-Wahab, M.A. El-Fattah, N.A. El-Khalik, H.S. Nassar and M.M. Abdelall, Prog. Org. Coat., 77, 1506 (2014); https://doi.org/10.1016/j.porgcoat.2014.04.026
  12. H.R. Dholariya, K.S. Patel, J.C. Patel, A.K. Patel and K.D. Patel, Med. Chem. Res., 22, 5848 (2013); https://doi.org/10.1007/s00044-013-0576-6
  13. C.G.L. Nongpiur, L. Dkhar, D.K. Tripathi, K.M. Poluri, W. Kaminsky and M.R. Kollipara, Inorg. Chim. Acta, 525, 120459 (2021); https://doi.org/10.1016/j.ica.2021.120459
  14. G.J. Kharadi and K.D. Patel, Appl. Organomet. Chem., 23, 391 (2009); https://doi.org/10.1002/aoc.1530
  15. M. Basavaraju, Y.D. Bodke and N. Kumar, ChemistrySelect, 7, e202200738 (2022); https://doi.org/10.1002/slct.202200738
  16. E. Khdhiri, K. Mnafgui, L. Ghazouani, A. Feriani, R. Hajji, W. Bouzanna, N. Allouche, J.-P. Bazureau, H. Ammar and S. Abid, Eur. J. Pharmacol., 881, 173137 (2020); https://doi.org/10.1016/j.ejphar.2020.173137
  17. V.V. Koppal, R.K. Hebsur, R.M. Melavanki, R. Kusanure and N.R. Patil, Macromol. Symp., 392, 1900200 (2020); https://doi.org/10.1002/masy.201900200
  18. M.S. Nair, D. Arish and R.S. Joseyphus, J. Saudi Chem. Soc., 16, 83 (2012); https://doi.org/10.1016/j.jscs.2010.11.002
  19. S. Poojari, P. Parameswar Naik and G. Krishnamurthy, Tetrahedron Lett., 53, 4639 (2012); https://doi.org/10.1016/j.tetlet.2012.06.017
  20. M.S. Refat, I.M. El-Deen, Z.M. Anwer and S. El-Ghol, J. Mol. Struct., 920, 149 (2009); https://doi.org/10.1016/j.molstruc.2008.10.059
  21. N. Venugopal, G. Krishnamurthy, H.S. Bhojya Naik and J.D. Manohara, J. Inorg. Organomet. Polym. Mater., 30, 2608 (2020); https://doi.org/10.1007/s10904-019-01394-8
  22. K. Buldurun, N. Turan, E. Bursal, A. Aras, A. Mantarci, N. Çolak, F. Türkan and I. Gülçin, J. Biomol. Struct. Dyn., 39, 6480 (2021); https://doi.org/10.1080/07391102.2020.1802340
  23. A.C. Ekennia, A.A. Osowole, L.O. Olasunkanmi, D.C. Onwudiwe, O.O. Olubiyi and E.E. Ebenso, J. Mol. Struct., 1150, 279 (2017); https://doi.org/10.1016/j.molstruc.2017.08.085
  24. E.F. Mohamed and S.S. Hassan, Egypt. J. Chem., 65, 11 (2022); https://doi.org/10.21608/EJCHEM.2022.131586.5798
  25. S.S. Hassan, Appl. Organomet. Chem., 32, e4170 (2018); https://doi.org/10.1002/aoc.4170
  26. Q.A.H. Jaber, N.A. Abdul-Rida and S. Adnan, Russ. J. Org. Chem., 56, 1622 (2020); https://doi.org/10.1134/S1070428020090195
  27. H.E. Hashem, E.A. Mohamed, A.A. Farag, N.A. Negm and E.A. Azmy, Appl. Organomet. Chem., 35, e6322 (2021); https://doi.org/10.1002/aoc.6322
  28. M.L. Low, G. Paulus, P. Dorlet, R. Guillot, R. Rosli, N. Delsuc, K.A. Crouse and C. Policar, Biometals, 28, 553 (2015); https://doi.org/10.1007/s10534-015-9831-2
  29. T. Khan, K. Sankhe, V. Suvarna, A. Sherje, K. Patel and B. Dravyakar, Biomed. Pharmacother., 103, 923 (2018); https://doi.org/10.1016/j.biopha.2018.04.021
  30. B.N. Nippu, R. Sandeep Kumar Jain, A. Rahman, H.M. Kumaraswamy and N.D. Satyanarayan, J. Mol. Struct., 1263, 133103 (2023).
  31. C.A. Lipinski, Drug Discov. Today. Technol., 1, 337 (2004); https://doi.org/10.1016/j.ddtec.2004.11.007
  32. E.F. Pettersen, T.D. Goddard, C.C. Huang, G.S. Couch, D.M. Greenblatt, E.C. Meng and T.E. Ferrin, J. Comput. Chem., 25, 1605 (2004); https://doi.org/10.1002/jcc.20084
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