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Vol. 36 No. 3 (2024): Vol 36 Issue 3, 2024

Copyright (c) 2024 Nagaraju Dharavath

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Design, Synthesis and Anticancer Activity of Novel Substituted (E)-2-Morpholinoquinoline- 3-carbaldehyde-O-((-1-aryl-1H-1,2,3-triazol-4-yl)methyl)oxime Derivatives

https://doi.org/10.14233/ajchem.2024.30734
Aruna Jyothi Chatla
Department of Chemistry, Telangana University, Nizamabad-503322, India
Jaya Praksh Rao Yerrabelly
1Department of Chemistry, Telangana University, Nizamabad-503322, India 2Department of Chemistry, Osmania University, Hyderabad-500007, India
Nagaraju Dharavath
Department of Chemistry, Telangana University, Nizamabad-503322, India
Panga Shyam
Department of Pharmaceutical Chemistry, Seva Shikshan Prasarak Mandals Dr. N.J. Paulbudhe College of Pharmacy, Ahmad Nagar-414003, India

Corresponding Author(s) : Jaya Praksh Rao Yerrabelly

jypr_19@yahoo.com

Asian Journal of Chemistry, Vol. 36 No. 3 (2024): Vol 36 Issue 3, 2024

Abstract

A new series of substituted (E)-2-morpholinoquinoline-3-carbaldehyde-O-((-1-phenyl-1H-1,2,3-triazol-4-yl)methyl)oxime scaffolds were synthesized from involving alkynyl quinoline oximes with various aryl azides by click reaction obtained corresponding compounds with high yields. The synthesized compounds were characterized by using IR, 1H NMR, 13C NMR and HRMS data. All the synthesized compounds screened anticancer activity against MCF-7, HeLa, PC-3 cell lines. All the compounds exhibited good results among them 8b, 8g and 8i compounds have shown prominent anticancer activity are compared to standard drug doxorubicin.

Keywords

Quinolines 1,2,3-Triazoles Click reaction Anticancer activity
Chatla, A. J., Yerrabelly, J. P. R., Dharavath, N., & Shyam, P. (2024). Design, Synthesis and Anticancer Activity of Novel Substituted (E)-2-Morpholinoquinoline- 3-carbaldehyde-O-((-1-aryl-1H-1,2,3-triazol-4-yl)methyl)oxime Derivatives. Asian Journal of Chemistry, 36(3), 618–622. https://doi.org/10.14233/ajchem.2024.30734
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