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Vol. 36 No. 1 (2024): Vol 36 Issue 1, 2024

Copyright (c) 2023 S.BAKKIALAKSHMI, A.KANIMOZHI

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Interaction Mechanism of Hesperidin and L-Tryptophan: A Experimental and Molecular Docking Studies

https://doi.org/10.14233/ajchem.2024.30750
A. Kanimozhi
Department of Physics, Annamalai University, Annamalai Nagar-608002, India
https://orcid.org/0009-0002-9490-466X
S. Bakkialakshmi
Department of Physics, Annamalai University, Annamalai Nagar-608002, India
https://orcid.org/0000-0002-3498-5384

Corresponding Author(s) : S. Bakkialakshmi

bakkialakshmis@rocketmail.com

Asian Journal of Chemistry, Vol. 36 No. 1 (2024): Vol 36 Issue 1, 2024

Abstract

The binding of L-tryptophan (L-Trp) and hesperidin (HES) was investigated by UV, fluorescence, synchronous fluorescence, time-resolved fluorescence, Fourier transform infrared (FTIR) spectroscopies, FRET, antibacterial activity, anticancer activity and molecular docking study. The flavonoid glycoside known as hesperidin has been shown to have therapeutic properties for a variety of disorders, including cancer diseases. Its low solubility and bioavailability cause it to be little absorbed, which means that a delivery mechanism is necessary in order for it to reach its therapeutic goal. Fluorescence data revealed that the fluorescence quenching mechanisms of L Trp by hesperidin are all static quenching procedures. Synchronous fluorescence spectroscopy shows the interaction between hesperidin  and L-Trp changes the hydrophobicity of the microenvironment of tryptophan (Trp) residues. The anticancer activity effect of  hesperidin and L-Trp on human cervical cancer cell lines was assessed using MTT and crystal violet assays.

Keywords

Hesperidin L-Tryptophan Fluorescence FTIR Antibacterial activity Anticancer activity Molecular docking
Kanimozhi , A., & Bakkialakshmi , S. (2023). Interaction Mechanism of Hesperidin and L-Tryptophan: A Experimental and Molecular Docking Studies. Asian Journal of Chemistry, 36(1), 215–222. https://doi.org/10.14233/ajchem.2024.30750
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