Trivalent Tetraazamacrocyclic Complexes of Cr(III) and Fe(III): Synthesis, Characterization and Antimicrobial Evaluation

Abstract

A novel series of macrocyclic compounds, [M(C₃₇H₃₆N₄)X]X₂; where M = Cr(III) and Fe(III); X = Clˉ, NO₃ˉ, CH₃COOˉ,  have been synthesized by using the template condensation between 3,4-diaminotoluene, dibenzoyl methane and dimedone in the presence of chromium(III) and iron(III). Various physio-chemical studies were used to characterize these complexes including PXRD, magnetic susceptibility, elemental analysis, electronic, IR and mass spectroscopy. These studies suggested that all the metal complexes have a five-coordinated square pyramidal geometry around the metal ion. The molar conductance values of these complexes in the range of 168-140 ohm^-1cm²mol^-1 indicated the electrolytic nature of these complexes. Furthermore, the antibacterial and antifungal behavior of these complexes was also examined by using different microbial strains i.e. Bacillus subtilis, Escherichia coli and Candida albicans. In addition to this, the results of antibacterial and antifungal of complexes were compared with commercially available antibacterial and antifungal drug i.e. ciprofloxacin and Amphotericin B, respectively.