Copyright (c) 2024 Sharada Etnoori, Nagendra Babu Chilakala, Raju Barothu, A.M.S. Krishna, Vishnu Thumma, Premalatha Kokku
This work is licensed under a Creative Commons Attribution 4.0 International License.
Synthesis and Characterization of Quinoxaline Anchored Bis(1,2,3-triazole) Derivatives as Potent Anticancer Agents
Corresponding Author(s) : Premalatha Kokku
Asian Journal of Chemistry,
Vol. 36 No. 11 (2024): Vol 36 Issue 11, 2024
Abstract
The synthesis of 1,4-bis((1-phenyl-1H-1,2,3-triazol-4-yl)methyl)-1,4-dihydroquinoxaline-2,3-dione derivatives (6a-l) was accomplished through click chemistry protocol. The synthesized compounds were screened for their in vitro anticancer activity against MCF-7, PC-3 and HeLa cancer cell lines by MTT assay using doxorubicin as standard reference. Compounds 6g (4-cyano), 6l (4-bromo), 6c (4-chloro) and 6i (4-methyl) demonstrated promising percentage growth inhibition against all the three cell lines in comparison to doxorubicin. The determined IC50 value proved their efficacy against all cell lines, serve as effective inhibitors of MCF-7, PC-3 and HeLa cancer cells and should be considered in the development of chemotherapeutics during the drug discovery process.
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- J. Jampilek, Curr. Med. Chem., 21, 4347 (2014); https://doi.org/10.2174/0929867321666141011194825
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- M. Nagamani, T. Vishnu, P. Jalapathi and M. Srinivas, J. Iran. Chem. Soc., 19, 1049 (2022); https://doi.org/10.1007/s13738-021-02365-y
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- F. Celik, Y. Unver, B. Barut, A. Ozel and K. Sancak, Med. Chem., 14, 230 (2018); https://doi.org/10.2174/1573406413666171120165226
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References
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M. Montana, V. Montero, O. Khoumeri and P. Vanelle, Molecules, 25, 2784 (2020); https://doi.org/10.3390/molecules25122784
J. Cogo, J. Cantizani, I. Cotillo, D.P. Sangi, T. Ueda-Nakamura, B.P.D. Filho, A.G. Corrêa, J.J. Martín and C.V. Nakamura, Bioorg. Med. Chem., 26, 4065 (2018); https://doi.org/10.1016/j.bmc.2018.06.033
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M. Montana, F. Mathias, T. Terme and P. Vanelle, Eur. J. Med. Chem., 163, 136 (2019); https://doi.org/10.1016/j.ejmech.2018.11.059
R. Sarges, H.R. Howard, R.G. Browne, L.A. Lebel, P.A. Seymour and B.K. Koe, J. Med. Chem., 33, 2240 (1990); https://doi.org/10.1021/jm00170a031
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S. Tariq, K. Somakala and M. Amir, Eur. J. Med. Chem., 143, 542 (2018); https://doi.org/10.1016/j.ejmech.2017.11.064
G. Yashwantrao and S. Saha, Org. Chem. Front., 8, 2820 (2021); https://doi.org/10.1039/D0QO01575J
Y. Seqqat, B. Hafez, M. Lahyaoui, F. Toscano, R. Seqqat, M.T. Arias, B.E. Kartah, H. Elmsellem, Y.K. Rodi and F.O. Chahdi, Mor. J. Chem., 12, 1323 (2024); https://doi.org/10.48317/IMIST.PRSM/morjchem-v12i3.48982
A. Rani, G. Singh, A. Singh, U. Maqbool, G. Kaur and J. Singh, RSC Adv., 10, 5610 (2020); https://doi.org/10.1039/C9RA09510A
M. Nagamani, T. Vishnu, P. Jalapathi and M. Srinivas, J. Iran. Chem. Soc., 19, 1049 (2022); https://doi.org/10.1007/s13738-021-02365-y
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H. Elamari, R. Slimi, G.G. Chabot, L. Quentin, D. Scherman and C. Girard, Eur. J. Med. Chem., 60, 360 (2013); https://doi.org/10.1016/j.ejmech.2012.12.025
V. Thumma, V. Mallikanti, R. Matta, R. Dharavath and P. Jalapathi, RSC Med. Chem., 15, 1283 (2024); https://doi.org/10.1039/D3MD00479A
A. Paquin, C. Reyes-Moreno and G. Bérubé, Molecules, 26, 2340 (2021); https://doi.org/10.3390/molecules26082340
S. Aitha, V. Thumma, S. Ambala, R. Matta, S. Panga and J. Pochampally, ChemistrySelect, 8, e202300405 (2023); https://doi.org/10.1002/slct.202300405
G. Yaku, D. Ramulu, V. Thumma, A. Paluri and R. Dharavath, ChemistrySelect, 8, e202300255 (2023); https://doi.org/10.1002/slct.202300255
F. Celik, Y. Unver, B. Barut, A. Ozel and K. Sancak, Med. Chem., 14, 230 (2018); https://doi.org/10.2174/1573406413666171120165226
J.F.W. Keana, S.M. Kher, S.X. Cai, C.M. Dinsmore, J. Guastella, J.-C. Huang, A.G. Glenn, V. Ilyin and Y. Lu, J. Med. Chem., 38, 4367 (1995); https://doi.org/10.1021/jm00022a003
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