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Vol. 36 No. 10 (2024): Vol 36 Issue 10, 2024

Copyright (c) 2024 Prasenjit Mondal, Saptarshi Samajdar, Piyali Khamkat, Vivek Barik, Sudip Kumar Mandal

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Synthesis, Molecular Docking and Pharmacological Evaluation of Some New Schiff and Mannich Bases of 5-Methylisatin Derivatives

https://doi.org/10.14233/ajchem.2024.32267
Prasenjit Mondal
Department of Pharmaceutical Technology, Brainware University, Barasat, Kolkata-700125, India
https://orcid.org/0000-0003-4695-3520
Saptarshi Samajdar
Department of Pharmaceutical Technology, Brainware University, Barasat, Kolkata-700125, India
https://orcid.org/0009-0007-6081-5809
Piyali Khamkat
Department of Pharmaceutical Technology, Brainware University, Barasat, Kolkata-700125, India
https://orcid.org/0000-0002-9351-4347
Vivek Barik
Department of Pharmaceutical Technology, Brainware University, Barasat, Kolkata-700125, India
https://orcid.org/0000-0002-5311-1383
Sudip Kumar Mandal
Department of Pharmaceutical Chemistry, Dr. B.C. Roy College of Pharmacy and AHS, Durgapur-713206, India
https://orcid.org/0000-0003-0097-1993

Corresponding Author(s) : Saptarshi Samajdar

saptarshisamajdar1993@gmail.com

Asian Journal of Chemistry, Vol. 36 No. 10 (2024): Vol 36 Issue 10, 2024

Abstract

Two novel series of Schiff and Mannich based 5-methylisatin were synthesized by Mannich reactions and evaluated for anthelmintic and antibacterial activities. The Mannich bases were synthesized from the Schiff base using various secondary amines and formaldehyde along with the derivatives of piperazinyl groups. N-Methyl piperazinyl (ICP-2B and ICM-2B) and piperidinyl derivatives (ICP-2C and ICM-2C) were found to have a highly significant anthelmintic potential. For compound ICP-2B, the paralysis time was observed at 4.936 ± 0.12 min at low concentration (0.1 % w/v) and 1.95 ± 0.10 min at high concentration (1% w/v). At low concentration (0.1%), compound ICM-2B, the paralysis time is 4.43 ± 0.17 min; at high concentration (1% w/v), it is 1.675 ± 0.08 min. These data indicated that compounds ICP-2B and ICM-2B has immense potential as anthelminthic and antimicrobial drug in future. Moreover, the in vitro study was confirmed by molecular docking studies, indicating both compounds ICP-2B and ICM-2B can find its use as novel drug against various pathogenic helminthes and bacteria.

Keywords

5-Methylisatin Schiff base Mannich base Anthelmintic activity Antibacterial activity Molecular docking
Mondal, P., Samajdar, S., Khamkat, P., Barik, V., & Mandal, S. K. (2024). Synthesis, Molecular Docking and Pharmacological Evaluation of Some New Schiff and Mannich Bases of 5-Methylisatin Derivatives. Asian Journal of Chemistry, 36(10), 2283–2292. https://doi.org/10.14233/ajchem.2024.32267
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