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Vol. 36 No. 10 (2024): Vol 36 Issue 10, 2024

Copyright (c) 2024 MADHU BALA MADHU BALA

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Synthesis and Characterization of Ester Derivatives of N-Phenylanthranilic Acid

https://doi.org/10.14233/ajchem.2024.32215
Madhu Bala
Department of Chemistry, Shri Khushal Das University, Hanumangarh-335801, India; Department of Chemistry, JCD Memorial College, Jan Nayak Ch. Devi Lal Vidyapeeth, Sirsa-125056, India
https://orcid.org/0009-0000-6717-2243
Rachna Yadav
Department of Chemistry, Shri Khushal Das University, Hanumangarh-335801, India
https://orcid.org/0009-0000-2732-2913
Amit Girdhar
Department of Chemistry, Shri Khushal Das University, Hanumangarh-335801, India
https://orcid.org/0000-0002-4622-0944

Corresponding Author(s) : Madhu Bala

madhukakkar14@gmail.com

Asian Journal of Chemistry, Vol. 36 No. 10 (2024): Vol 36 Issue 10, 2024

Abstract

N-Phenylanthranilic acid (fenamic acid) serves as the fundamental structure for synthesizing several non-steroidal anti-inflammatory drugs, antibacterial drugs and also functions as a modulator of membrane transport. To reduce the dose-related side effects of existing drugs, research is focussing to improve fenamic acid derivative solubility and bioavailability. A series of ester derivatives of N-phenylanthranilic acid (MB-1 to MB-5) viz. 2-(phenyl amino)methyl benzoate, 2-(phenyl amino)ethyl benzoate, 2-(phenyl amino)isopropyl benzoate,
2-(phenyl amino)butyl benzoate and 2-(phenyl amino)phenyl benzoate were synthesized. The chemical structures and functional groups of these derivatives were confirmed using elemental analysis and spectral data. Furthermore, the derived compounds were evaluated for their antibacterial activity against Escherichia coli (Gram-negative) and Staphylococcus aureus (Gram-positive) strains using the agar-well diffusion method followed by molecular docking studies to predict binding interactions of the synthesized compounds with DNA gyrase.

Keywords

N-Phenyl anthranilic acid Ester derivatives Antimicrobial activity Antibacterial activity Agar-well diffusion
Bala, M., Yadav, R., & Girdhar, A. (2024). Synthesis and Characterization of Ester Derivatives of N-Phenylanthranilic Acid. Asian Journal of Chemistry, 36(10), 2269–2274. https://doi.org/10.14233/ajchem.2024.32215
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