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Vol. 36 No. 10 (2024): Vol 36 Issue 10, 2024

Copyright (c) 2024 Balakrishna Kalluraya, Sharatha Kumar, Priya

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis and SAR Studies of Some Novel Series of Pyrimidine Analogues

https://doi.org/10.14233/ajchem.2024.32345
Balakrishna Kalluraya
Department of P.G. Studies and Research in Chemistry, Yenepoya Institute of Arts, Science, Commerce and Management, Yenepoya Deemed to be University, Mangaluru-575002, India
https://orcid.org/0000-0003-0442-7178
Sharatha Kumar
Department of P.G. Studies and Research in Chemistry, Yenepoya Institute of Arts, Science, Commerce and Management, Yenepoya Deemed to be University, Mangaluru-575002, India
Priya
Department of P.G. Studies and Research in Chemistry, Yenepoya Institute of Arts, Science, Commerce and Management, Yenepoya Deemed to be University, Mangaluru-575002, India

Corresponding Author(s) : Balakrishna Kalluraya

bkalluraya@gmail.com

Asian Journal of Chemistry, Vol. 36 No. 10 (2024): Vol 36 Issue 10, 2024

Abstract

A series of novel ethyl-4-methyl-6-phenyl-2-(substituted thio)pyrimidine-5-carboxylate (4a-m), ethyl-4-methyl-phenyl-2-(substituted sulfinyl)pyrimidine-5-carboxylate (5a-m) and ethyl-4-methyl-phenyl-2-(substituted sulfonyl)pyrimidine-5-carboxylate (6a-m) were synthesized by multi-step organic synthesis. The synthesized compounds were characterized by 1H NMR, 13C NMR, LCMS and elemental analysis. Most of the compounds showed significant antibacterial and anticancer activity comparable to or higher than the standard employed.

Keywords

Pyrimidine analogues Sulfinyl pyrimidine Sulfonyl derivatives Antibacterial activity Anticancer activity
Kalluraya, B., Kumar, S., & Priya. (2024). Synthesis and SAR Studies of Some Novel Series of Pyrimidine Analogues. Asian Journal of Chemistry, 36(10), 2397–2404. https://doi.org/10.14233/ajchem.2024.32345
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References
  1. X.A.F. Cook, A. de Gombert, J. McKnight, L.R.E. Pantaine and M.C. Willis, Angew. Chem. Int. Ed., 60, 11068 (2021); https://doi.org/10.1002/anie.202010631
  2. Y.-J. Cherng, Tetrahedron, 58, 4931 (2002); https://doi.org/10.1016/S0040-4020(02)00424-6
  3. M.S. Masoud, A.A. Ibrahim, E.A. Khalil and A. El-Marghany, Spectrochim. Acta A Mol. Biomol. Spectrosc., 67, 662 (2007); https://doi.org/10.1016/j.saa.2006.07.046
  4. A. Odani, H. Kozlowski, J. Swiatek-Kozlowska, J. Brasuñ, B.P. Operschall and H. Sigel, J. Inorg. Biochem., 101, 727 (2007); https://doi.org/10.1016/j.jinorgbio.2006.12.014
  5. L.D. Markley, K.E. Arndt, T.W. Balko, T.M. Bargar, F.R. Green and J.L. Jackson, 222nd ACS National Meeting, Chicao, IL, USA (2001).
  6. K. Steinbeck and S. Dutzmann, Chem. Abstr., 112, 55905 (1989).
  7. E. Tanaka, S. Hayashi, N. Okuma and T. Nakagawa, Chem. Abstr., 111, 153832 (1989).
  8. N. Zenker, Thyroid Function and Thyroid Drugs. Principles of Medicinal Chemistry, Lea and Febiger, Philadelphia, London, edn. 3, pp. 603-621 (1990).
  9. P.F. Lamie and J.N. Philoppes, J. Enzym. Inhib. Med. Chem., 35, 864 (2020); https://doi.org/10.1080/14756366.2020.1740922
  10. C. Vetter, C. Wagner, G.N. Kaluderovic, R. Paschke and D. Steinborn, Inorg. Chim. Acta, 362, 189 (2009); https://doi.org/10.1016/j.ica.2008.03.085
  11. A. Mai, M. Artico, G. Sbardella, S. Massa, A.G. Loi, E. Tramontano, P. Scano and P. La Colla, J. Med. Chem., 38, 3258 (1995); https://doi.org/10.1021/jm00017a010
  12. L. Ji, F.-E. Chen, E. De Clercq, J. Balzarini and C. Pannecouque, J. Med. Chem., 50, 1778 (1995); https://doi.org/10.1021/jm061167r
  13. P.C. Shyma, B. Kalluraya, S.K. Peethambar, S. Telkar and T. Arulmoli, Eur. J. Med. Chem., 68, 394 (2013); https://doi.org/10.1016/j.ejmech.2013.07.019
  14. B. Lingappa, B. Kalluraya, S.N. Rai and N.S. Kumar, Organ. Chem. Indian J., 2, 5 (2006).
  15. A.K. Kadambar, B. Kalluraya and S.M. Kumar, J. Heterocycl. Chem., 57, 3845 (2020); https://doi.org/10.1002/jhet.4067
  16. H.A.N. Banu, B. Kalluraya, N. Manju, R. Ramu, S.M. Patil, K.M. Lokanatha Rai and N. Kumar, Chemistry Select, 8, e202203578 (2023); https://doi.org/10.1002/slct.202203578
  17. D.V. Geetha, C.L. Sharath, N. Shivakumar, B.N. Lakshminarayana, K.M. Chandini and K. Balakrishna, J. Mol. Struct., 1317, 139016 (2024); https://doi.org/10.1016/j.molstruc.2024.139016
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