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Vol. 36 No. 10 (2024): Vol 36 Issue 10, 2024

Copyright (c) 2024 Shruthika D. Rakhe, Shreyas S. Mahurkar, Rahul A. More, Baliram D. Kamale, Manisha P. Munde, Tukaram E. Khatke, Jaman A. Angulwar

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Tetrabutylammonium Hydrogen Sulfate (TBAHS) Catalyzed Microwave-Assisted Synthesis of 3,4,5,6,7,9-Hexahydro-1H-xanthene-1,8-(2H)-dione Derivatives and its Biological Study

https://doi.org/10.14233/ajchem.2024.32230
Shruthika D. Rakhe
Department of Chemistry, Dayanand Science College, Latur-413512, India
https://orcid.org/0009-0004-6523-0445
Shreyas S. Mahurkar
Department of Chemistry, Dayanand Science College, Latur-413512, India
https://orcid.org/0000-0003-2568-3787
Rahul A. More
Department of Microbiology, Dayanand Science College, Latur-413512, India
https://orcid.org/0000-0001-8201-4622
Baliram D. Kamale
Department of Chemistry, Dayanand Science College, Latur-413512, India
https://orcid.org/0009-0004-2636-8425
Manisha P. Munde
Department of Chemistry, Dayanand Science College, Latur-413512, India
https://orcid.org/0009-0003-4797-9850
Tukaram E. Khatke
Department of Chemistry, NKSPT Arts, Science & Commerce College, Badnapur-431202, India
https://orcid.org/0009-0009-6543-7506
Jaman A. Angulwar
Department of Chemistry, Dayanand Science College, Latur-413512, India
https://orcid.org/0000-0003-0858-7312

Corresponding Author(s) : Jaman A. Angulwar

jaangulwar@gmail.com

Asian Journal of Chemistry, Vol. 36 No. 10 (2024): Vol 36 Issue 10, 2024

Abstract

In this study, a facile and eco-friendly synthesis of novel 3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione derivatives using tetrabutylammonium hydrogen sulfate (TBAHS) as a catalyst in the microwave reactor is presented. The reaction involved the condensation of aromatic aldehydes with 1,3-cyclohexanedione in ethanol as solvent, offering significant advantages in terms of reaction rate, yield and purity. The use of TBAHS as catalyst in conjunction with microwave irradiation facilitated the formation of the target xanthene derivatives in remarkably short reaction times. Moreover, Monowave 50 microwave reactor provided precise control over reaction parameters, enabling rapid optimization of reaction conditions. Further these synthesized compounds were systematically evaluated for their antibacterial, antituberculosis and antioxidant activities.

Keywords

Xanthene-1,8(2H)-dione Microwave irradiation 1,3-Cyclohexanedione Biological activity Antitubercular
Rakhe, S. D., Mahurkar, S. S., More, R. A., Kamale, B. D., Munde, M. P., Khatke, T. E., & Angulwar, J. A. (2024). Tetrabutylammonium Hydrogen Sulfate (TBAHS) Catalyzed Microwave-Assisted Synthesis of 3,4,5,6,7,9-Hexahydro-1H-xanthene-1,8-(2H)-dione Derivatives and its Biological Study. Asian Journal of Chemistry, 36(10), 2359–2367. https://doi.org/10.14233/ajchem.2024.32230
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