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Vol. 36 No. 10 (2024): Vol 36 Issue 10, 2024

Copyright (c) 2024 Ajitkumar Ingle, Shrimant Rathod

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Synthesis, Characterization and Antifungal Studies of Novel Substituted Benzaldehyde Derivatives of 2-Amino-6-ferrocenyl-4-phenylpyrimidine

https://doi.org/10.14233/ajchem.2024.32303
Ajitkumar Vijay Ingle
Department of Chemistry, Bhavan’s Hazarimal Somani College, Mumbai-400007, India
https://orcid.org/0000-0001-5329-2260
Shrimant Vhannappa Rathod
Department of Chemistry, Bhavan’s Hazarimal Somani College, Mumbai-400007, India

Corresponding Author(s) : Ajitkumar Vijay Ingle

inglevajit@gmail.com

Asian Journal of Chemistry, Vol. 36 No. 10 (2024): Vol 36 Issue 10, 2024

Abstract

A series of novel 2-amino-6-ferrocenyl-4-phenylpyrimidine (AFPP) derivatives (6a-j) have been synthesized by coupling AFPP with thioglycolic acid and various substituted benzaldehydes (a-j) using standard 1,3-dicyclohexylcarbodiimide (DCC) protocol. The synthesized compounds were characterized by FTIR, 13C NMR, 1H NMR and MS techniques. The synthesized compounds 6a-j were evaluated for antifungal activities against Candida albicans MTCC 183. Comparing compounds 6a-j to standard amphotericin B, it was found that the synthesized compounds showed excellent activity.

Keywords

2-Amino-6-ferrocenyl-4-phenylpyrimidine Substituted benzaldehydes Antifungal activity Molecular docking study
Ingle, A. V., & Rathod, S. V. (2024). Synthesis, Characterization and Antifungal Studies of Novel Substituted Benzaldehyde Derivatives of 2-Amino-6-ferrocenyl-4-phenylpyrimidine. Asian Journal of Chemistry, 36(10), 2307–2310. https://doi.org/10.14233/ajchem.2024.32303
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