Copyright (c) 2024 Ajitkumar Ingle, Shrimant Rathod
This work is licensed under a Creative Commons Attribution 4.0 International License.
Synthesis, Characterization and Antifungal Studies of Novel Substituted Benzaldehyde Derivatives of 2-Amino-6-ferrocenyl-4-phenylpyrimidine
Corresponding Author(s) : Ajitkumar Vijay Ingle
Asian Journal of Chemistry,
Vol. 36 No. 10 (2024): Vol 36 Issue 10, 2024
Abstract
A series of novel 2-amino-6-ferrocenyl-4-phenylpyrimidine (AFPP) derivatives (6a-j) have been synthesized by coupling AFPP with thioglycolic acid and various substituted benzaldehydes (a-j) using standard 1,3-dicyclohexylcarbodiimide (DCC) protocol. The synthesized compounds were characterized by FTIR, 13C NMR, 1H NMR and MS techniques. The synthesized compounds 6a-j were evaluated for antifungal activities against Candida albicans MTCC 183. Comparing compounds 6a-j to standard amphotericin B, it was found that the synthesized compounds showed excellent activity.
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M. Patra and G. Gasser, Nat. Rev. Chem., 1, 0066 (2017); https://doi.org/10.1038/s41570-017-0066
N. Fu, Y. Yuan, M. Pang, J. Wang and C. Peppe, J. Organomet. Chem., 672, 52 (2003); https://doi.org/10.1016/S0022-328X(03)00139-6
T. Mochida, F. Shimizu, H. Shimizu, K. Okazawa, F. Sato and D. Kuwahara, J. Organomet. Chem., 692, 1834 (2007); https://doi.org/10.1016/j.jorganchem.2006.11.011
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