Green Synthesis of Spiropyranone 3-Aryl-4-Methylcoumarin Derivatives using Carbonyldiimidazole

D. Ashok; E.V.L. Madhuri; M. Sarasija

doi:10.14233/ajchem.2020.22376

Issue

Vol. 32 No. 1 (2020): Vol 32 Issue 1

Issue Published : 18 September 2019

This work is licensed under a Creative Commons Attribution 4.0 International License.

Green Synthesis of Spiropyranone 3-Aryl-4-Methylcoumarin Derivatives using Carbonyldiimidazole

https://doi.org/10.14233/ajchem.2020.22376

D. Ashok

Green and Medicinal Chemistry Lab, Department of Chemistry, Osmania University, Hyderabad-500007, India

https://orcid.org/0000-0001-5490-5006

E.V.L. Madhuri

Green and Medicinal Chemistry Lab, Department of Chemistry, Osmania University, Hyderabad-500007, India; Department of Chemistry, Telangana University, Nizamabad-503344, India

M. Sarasija

Department of Chemistry, Satavahana University, Karimnagar-505001, India

Corresponding Author(s) : D. Ashok

ashokdou@gmail.com

Asian Journal of Chemistry, Vol. 32 No. 1 (2020): Vol 32 Issue 1
Article Published : 18 September 2019

Abstract

A series of spiropyranone 3-aryl-4-methylcoumarin derivatives have been synthesized from monospiro-2-hydroxy acetophenone in a novel and efficient green method using imidazolyl intermediates and inorganic base. Imidazolyl intermediates were in turn generated by grinding the respective phenylacetic acid along with carbonyldiimidazole (CDI). Similarly, monospiro-2-hydroxy acetophenone derivatives were prepared selectively by avoiding formation of bis derivatives following literature procedure. The titled compounds were purified by preparative TLC technique and were characterized by IR, ¹H NMR, ¹³C NMR as well as mass spectral methods.

Keywords

Spiropyranone coumarin Carbonyl diimidazole Green synthesis

(1)

Ashok, D.; Madhuri, E.; Sarasija, M. Green Synthesis of Spiropyranone 3-Aryl-4-Methylcoumarin Derivatives Using Carbonyldiimidazole. ajc 2019, 32, 205-208.

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