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Vol. 38 No. 9 (2026): Vol 38 Issue 9 Year 2026

Copyright (c) 2026 Riddhi Prakash Trivedi, Prajesh Prajapati

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Silver Nanoparticles Augmented Polycystamine Coated Glassy Carbon Electrodes for Sensitive Sensing of N-Nitrosodimethylamine

https://doi.org/10.14233/ajchem.2026.36463
Riddhi Trivedi
School of Pharmacy, National Forensic Sciences University, Gandhinagar-382007, India
https://orcid.org/0009-0002-3256-0793
Prajesh Prajapati
School of Pharmacy, National Forensic Sciences University, Gandhinagar-382007, India
https://orcid.org/0000-0003-1619-7939

Corresponding Author(s) : Riddhi Trivedi

riddhitrivedi138@gmail.com

Asian Journal of Chemistry, Vol. 38 No. 9 (2026): Vol 38 Issue 9 Year 2026

Abstract

Nitrosamine impurities, particularly N-nitrosodimethylamine (NDMA), are potent genotoxic and carcinogenic compounds that can pose significant risks even at trace concentrations. Their occurrence in pharmaceutical products, including cardiovascular, antidiabetic and gastro-retentive drugs, has raised major regulatory concerns, leading to recalls and restrictions on affected products. This study presents an electrochemical sensor for the trace-level detection of NDMA using a polymer-modified glassy carbon electrode (GCE). Silver nanoparticles embedded in polycystamine were integrated onto the GCE surface to enhance the analytical response, sensitivity and selectivity toward NDMA. The electrochemical behavior and quantitative detection of NDMA were investigated using cyclic voltammetry (CV), differential pulse voltammetry (DPV) and square-wave voltammetry (SWV). Surface morphology and modification of the electrode were examined by scanning electron microscopy (SEM). Interference studies were performed to assess the selectivity of the sensor in the presence of potentially coexisting species. The developed silver nanoparticle–polycystamine/GCE platform provides a sensitive and selective electrochemical approach for NDMA detection, with potential application in pharmaceutical quality control and analysis of complex industrial matrices.

Keywords

Nitroso compounds Silver nanoparticle Polycystamine Electrochemical sensor Voltammetric techniques
(1)
Trivedi, R.; Prajapati, P. Silver Nanoparticles Augmented Polycystamine Coated Glassy Carbon Electrodes for Sensitive Sensing of N-Nitrosodimethylamine. ajc 2026, 38, 2387-2397.
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